Cited by 177Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchNeuroendocrine regulation and behavior

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Social behavior deficits in the Fmr1 mutant mouse

Mineur, Yann S., Huynh, Linh X., Crusio, Wim E.·2006·Behavioural Brain Research

DOI 10.1016/j.bbr.2005.11.004

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Abstract

Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.

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Authors: Mineur, Y. S., Huynh, L. X., & Crusio, W. E.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Crusio, Wim E.
ORCID: Mineur, Yann S.
Crusio, Wim E.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2006-03
Volume: 168
Issue: 1
Pages: 172-175
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2005.11.004
OpenAlex: W2032131334
Cited by: 177
References: 22
Citations by year: 2026: 3 · 2025: 12 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 20
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: March of Dimes Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: Fmr1 knockout mice, social interaction deficits, autism model, inbred mouse strains, habituation, ovariectomized females, FMR1 gene, social behavior
MeSH terms: Animals, Autistic Disorder, Female, Habituation, Psychophysiologic, Interpersonal Relations, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mutation, Ovariectomy, Pilot Projects, Social Behavior, Social Environment, Species Specificity, Mice, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1

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Social behavior deficits in the Fmr1 mutant mouse

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