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Cited by 21Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats

LEGAULT, G, SMITH, C, BENINGER, R·2006·Behavioural Brain Research
DOI 10.1016/j.bbr.2006.02.010
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Abstract

Systemic treatments with acetylcholine (ACh) or dopamine (DA) receptor antagonists during hours 0-4 but not during hours 5-8 following training on a radial arm maze (RAM) or lesions of the dorsal striata impair learning. This suggested that intra-striatal infusions of ACh or DA receptor antagonists during hours 0-4 following training may impair learning. Rats were randomly assigned to groups (ns=5-11) receiving dorsal striatal infusions of the ACh receptor antagonist scopolamine (0-18 microg/microL at 0 and 2h or at 4 and 6h after training), the DA receptor antagonist cis-flupenthixol (0-25 microg/microL at 0, 4 or 12h after training) or the inactive isomer trans-flupenthixol (6 microg/microL at 0 h after training). Scopolamine and cis-flupenthixol impaired the habit-learning version of the task. Given after hours 0-4 following training, the effects of scopolamine were diminished but those of cis-flupenthixol were not. Trans-flupenthixol produced less impairment than cis-flupenthixol. Results suggest that ACh and DA receptors in the dorsal striatum during hours 0-4 following training play a role in habit learning.

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  • Blocking muscarinic cholinergic receptors during REM sleep windows by scopolamine consistently impairs memory in a habit learning version of the radial arm maze.

    “Blocking muscarinic cholinergic receptors during “REM sleep windows” (i.e., time periods after learning in which REM sleep deprivation effectively impaired consolidation of respective materials, see sect.IIB) by administration of scopolamine consistently impaired memory in a habit learning version of the radial arm maze (720, 721).”

    From About Sleep's Role in Memory (2013) · cites this paper as [721]

  • Dopamine receptor blocker flupenthixol infused into dorsal striatum 0-4 h after learning during REM sleep windows exerts the same impairing effect on habit consolidation as scopolamine.

    “Legault et al. (721) reported that the dopamine receptor blocker flupenthixol infused into the dorsal striatum 0 -4 h after learning during “REM sleep windows” exerted the same impairing effect on habit consolidation as observed after scopolamine.”

    From About Sleep's Role in Memory (2013) · cites this paper as [721]

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Authors
LEGAULT, G., SMITH, C., & BENINGER, R.
Affiliations
  • Sunnybrook Health Science Centre (CA)
  • Trent University (CA)
  • Queen's University (CA)
Corresponding author
LEGAULT, G
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-06-03
Volume
170
Issue
1
Pages
148-155
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2006.02.010
OpenAlex
W2107943289
Cited by
21
References
19
Citations by year
2021: 2 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 3
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Trent University
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
scopolamine, cis-flupenthixol, acetylcholine receptor, dopamine receptors, dorsal striatum, radial maze, habit learning, learning disabilities
MeSH terms
Acetylcholine, Animals, Brain, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Flupenthixol, Male, Mental Recall, Scopolamine, Sleep, REM, Rats, Sprague-Dawley, Dopamine Antagonists, Muscarinic Antagonists, Maze Learning, Rats

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