Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats
Abstract
Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological validation of this model. Animals were socially stressed for 5 weeks and, in parallel, after the first week of stress, they were subjected to chronic (4 weeks) treatment with the antidepressant drug citalopram. The drug was administered via drinking water (30 mg/kg). The optimal dose of citalopram was determined in a pilot study. After 4 weeks of treatment, plasma levels of citalopram and its metabolite were found to be within the human therapeutic range. The effects of social stress and citalopram treatment were assessed by behavioural tests. Chronically stressed rats showed reduced locomotor and exploratory activity, reduced sucrose preference and increased immobility time in the forced swimming test. Chronic oral administration of citalopram abolished those effects and normalized behaviours related to motivation and reward sensitivity. These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats.
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Repeated exposures to social defeat stress in rodents cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors.
“Repeated exposures to social defeat stress in rodents, for example, cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors10,14–17.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [15]
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- Authors
- Rygula, R., Abumaria, N., Flügge, G., Hiemke, C., Fuchs, E., Rüther, E., & Havemann-Reinecke, U.
- Affiliations
- German Primate Center (DE)
- Johannes Gutenberg University Mainz (DE)
- University of Göttingen (DE)
- Corresponding author
- Abumaria, Nashat
- Venue
- Behavioural Pharmacology
- Published
- 2006-02
- Volume
- 17
- Issue
- 1
- Pages
- 19-29
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1963953631
- Cited by
- 104
- References
- 56
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 9
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- citalopram, chronic social stress, resident-intruder paradigm, antidepressant efficacy, anhedonia, motivational deficits, reward sensitivity, sucrose preference, forced swim test, locomotor activity, exploratory activity, plasma drug concentration, model validation
- MeSH terms
- Administration, Oral, Animals, Antidepressive Agents, Depression, Disease Models, Animal, Dominance-Subordination, Dose-Response Relationship, Drug, Exploratory Behavior, Food Preferences, Male, Motivation, Motor Activity, Social Behavior, Social Environment, Stress, Psychological, Sucrose, Swimming, Taste, Citalopram, Rats, Wistar, Rats
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