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Novelty seeking, incentive salience and acquisition of cocaine self-administration in the rat
Open accessAbstract
It has been suggested that incentive salience plays a major role in drug abuse and the development of addiction. Additionally, novelty seeking has been identified as a significant risk factor for drug abuse. However, how differences in the readiness to attribute incentive salience relate to novelty seeking and drug abuse vulnerability has not been explored. The present experiments examined how individual differences in incentive salience attribution relate to novelty seeking and acquisition of cocaine self-administration in a preclinical model. Rats were first assessed in an inescapable novelty task and a novelty place preference task (measures of novelty seeking), followed by a Pavlovian conditioned approach task for food (a measure of incentive salience attribution). Rats then were trained to self-administer cocaine (0.3 or 1.0 mg/kg/infusion) using an autoshaping procedure. The results demonstrate that animals that attributed incentive salience to a food-associated cue were higher novelty seekers and acquired cocaine self-administration more quickly at the lower dose. The results suggest that novelty-seeking behavior may be a mediator of incentive salience attribution and that incentive salience magnitude may be an indicator of drug reward.
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“Moreover in these lines, unlike the case in outbred rats13,28, there is a strong correlation between locomotor response to novelty and the tendency to sign-track15.”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [28]
In the citing paper
“Approach to, rather than avoidance of, novelty reflects positive motivation (Beckmann, Marusich, Gipson, & Bardo, 2011; Powell, Geyer, Gallagher, & Paulus, 2004).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Beckmann, Marusich, Gipson, & Bardo, 2011
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A selective role for dopamine in stimulus-reward learning
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Metadata
- Authors
- Beckmann, J. S., Marusich, J. A., Gipson, C. D., & Bardo, M. T.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Beckmann, Joshua S.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 216
- Issue
- 1
- Pages
- 159-165
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2975769
- OpenAlex
- W2068588050
- Cited by
- 119
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 4 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 16 · 2012: 6
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (T32DA016176, T32DA007304, P50DA005312, P50 DA05312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- novelty seeking, incentive salience, cocaine self-administration, drug acquisition, Pavlovian conditioned approach, individual differences, drug reward, addiction vulnerability, rats
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Cocaine, Conditioning, Psychological, Exploratory Behavior, Individuality, Male, Motor Activity, Self Administration, Rats, Sprague-Dawley, Rats
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