Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats
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There is controversy about the abuse liability of methylphenidate (MPH) in humans, and MPH has yet to be established fully as a reinforcer in rats. The present experiment examined whether intravenous MPH served as a reinforcer in rats, and how individual differences in impulsivity impacted MPH self-administration. Rats were exposed to a delay-discounting procedure, and then were implanted with an intravenous catheter to assess self-administration of 0.56 mg/kg/infusion MPH at different fixed ratio values. Self-administration rates of different MPH doses (0.03-1.0 mg/kg/infusion) were also examined. Both high and low impulsive rats acquired MPH self-administration at the same rate. All rats pressed more on the active lever than the inactive lever regardless of MPH dose, and pressed more for MPH than for saline. High impulsive rats self-administered more MPH than low impulsive rats at a low unit dose (0.1 mg/kg/infusion), though not at higher doses, indicating that individual differences in impulsive choice influence the dose-dependent reinforcing effects of MPH.
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Some evidence suggests impulsive choice predicts higher cocaine or methylphenidate intake.
“some evidence suggests impulsive choice is predictive of higher cocaine or methylphenidate intake”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Marusich & Bardo, 2009
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- Authors
- Marusich, J. A., & Bardo, M. T.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Bardo, Michael T.
- Venue
- Behavioural Pharmacology
- Published
- 2009-09
- Volume
- 20
- Issue
- 5-6
- Pages
- 447-454
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC2754277
- OpenAlex
- W2066412185
- Cited by
- 72
- References
- 62
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA012964, T32DA007304, P50DA005312, P50 DA05312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- methylphenidate, impulsivity, delay discounting, self-administration, abuse liability, individual differences, reinforcers, dose dependence, rats
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Animals, Behavior, Animal, Choice Behavior, Conditioning, Operant, Dose-Response Relationship, Drug, Extinction, Psychological, Impulsive Behavior, Male, Methylphenidate, Reaction Time, Reinforcement Schedule, Self Administration, Time Factors, Rats, Sprague-Dawley, Rats
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