Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats
Abstract
Rationale Previous research in humans suggests a relationship between drug abuse and impulsivity as shown by selection of a smaller immediate reward over a larger delayed reward. However, it is not clear whether impulsivity precedes drug abuse or drug abuse influences impulsivity.Objective The hypothesis of the present experiment was that rats selected for choosing smaller, immediate over larger, delayed food would acquire IV cocaine self-administration faster than those choosing larger, delayed food rewards.Methods Female rats were screened for locomotor activity and trained on a delay discounting procedure that allowed them access to two response levers and a food pellet dispenser. Under a fixed-ratio (FR) 1 schedule, responding on one lever resulted in immediate delivery of one 45 mg pellet, while responding on the other lever resulted in delivery of three 45 mg pellets after a variable delay that increased after responses on the delay lever and decreased after responses on the immediate lever. For each rat, a mean adjusted delay (MAD) was calculated for each daily session, and stability was defined as MADs varying less than 5 s across 5 days. Based on their average MADs, rats were separated into low impulsive (LoI) and high impulsive (HiI) groups, implanted with an indwelling IV catheter, and trained to lever press for cocaine (0.2 mg/kg) under an FR1 schedule.Results There were no differences in locomotor activity between the LoI and HiI groups; however, a greater percentage of the HiI group acquired cocaine self-administration, and they did so at a significantly faster rate than the LoI rats.Conclusions Performance on the delay discounting model of impulsivity predicted vulnerability to subsequent acquisition of cocaine self-administration.
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Male and female rats that mostly choose smaller-sooner food are more likely to acquire low-dose cocaine self-administration than rats that prefer to wait for a larger food reward.
“Male and female rats that predominantly choose smaller-sooner food rewards are more likely to acquire low-dose cocaine self-administration than rats that prefer to wait for a larger food reward”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Perry et al., 2005
In rats, high impulsivity measured by delay discounting is a vulnerability factor for both alcohol and cocaine self-administration.
“In rats, high impulsivity – measured by delay discounting – is a vulnerability factor for both alcohol (Poulos et al., 1995) and cocaine (Perry and Carroll, 2008; Perry et al., 2005) self-administration.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Perry et al., 2005
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- Authors
- Perry, J. L., Larson, E. B., German, J. P., Madden, G. J., & Carroll, M. E.
- Affiliations
- University of Minnesota (US)
- University of Wisconsin–Eau Claire (US)
- Corresponding author
- Perry, Jennifer L.
- ORCID
- Madden, Gregory J.
- Venue
- Psychopharmacology
- Published
- 2004-08-27
- Volume
- 178
- Issue
- 2-3
- Pages
- 193-201
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1967545147
- Cited by
- 388
- References
- 58
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 27 · 2017: 16 · 2016: 23 · 2015: 21 · 2014: 34 · 2013: 35 · 2012: 26
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - USU (Utah State University) (submittedVersion)
- Funders
- National Institutes of Health (1r03da013575-01)
- National Institute on Drug Abuse (K05 DA 15267, R01 DA03240, R03 DA13575-01, R01DA003240, K05DA015267)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- impulsivity, delay discounting, cocaine self-administration, female rats, drug acquisition, locomotor activity, intravenous cocaine
- MeSH terms
- Animals, Cocaine, Conditioning, Operant, Female, Food Preferences, Impulsive Behavior, Motivation, Reaction Time, Retention, Psychology, Self Administration, Substance Abuse, Intravenous, Rats, Wistar, Cocaine-Related Disorders, Rats
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