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Cited by 11Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Rostral ventromedial medulla modulates nociception and tonic immobility behavior through connections with the A7 catecholaminergic region.

da Silva, Luis Felipe Souza, Coimbra, Norberto Cysne, Menescal-de-Oliveira, Leda·2012·Behavioural Brain Research
DOI 10.1016/j.bbr.2012.05.020
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Abstract

Cholinergic stimulation of the rostral ventromedial medulla (RVM) produces antinociception and reduces the duration of tonic immobility (TI) behavior in guinea pigs. Previous studies indicated that cholinergic antinociception in the RVM is mediated through connections with the A7 catecholaminergic cell group (A7). In the current study, we tested the role of the A7 in both the antinociception and reduction of TI duration mediated by cholinergic stimulation of the RVM. In addition, we used biotinylated dextran amines (BDA) to evaluate the connections between the RVM and A7. The microinjection of the cholinergic agonist carbachol into the RVM produced antinociception and reduced TI behavior duration. These effects were blocked by prior administration of lidocaine to the A7. However, the microinjection of lidocaine into the A7 prior to saline injection into the RVM had no effect on either the nociceptive or TI responses. The microinjection of the neurotracer BDA into the RVM positively stained fibers and synaptic boutons in the A7, indicating that there are direct projections from the RVM to the A7. Taken together, our results indicate that the antinociception and reduction of TI behavior duration after cholinergic stimulation of the RVM depends on connections with the A7.

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Crossref · 10.1016/j.bbr.2012.05.020

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  • Flight or fight involves non-opioid analgesia, which can be evoked by activation of the LPAG, and projections to the spinal cord block ascending pain signals.

    “Flight or fight involves non-opioid analgesia,28,29 which can be evoked by activation of the LPAG.28 Projections to the spinal cord block ascending pain signals.30”

    From Fear and the Defense Cascade (2015) · cites this paper as [29]

  • For humans, the defense cascade model includes collapsed immobility, characterized by bradycardia combined with hypotonicity of skeletal muscles.

    “For humans, the model includes collapsed immobility,††,7,16,35 which is characterized by bradycardia combined with hypotonicity of skeletal muscles.”

    From Fear and the Defense Cascade (2015) · cites this paper as [16]

  • Non-opioid analgesia accompanies the active defense responses (flight or fight), and opioid analgesia accompanies the passive defense responses (freezing, tonic immobility, collapsed immobility, and quiescent immobility).

    “Non-opioid analgesia accompanies the “active” defense responses (flight or fight), and opioid analgesia accompanies the “passive” defense responses (freezing, tonic immobility, collapsed immobility, and quiescent immobility).28–30”

    From Fear and the Defense Cascade (2015) · cites this paper as [29]

  • The integrated freeze response includes an opioid-mediated analgesia, which is itself mediated by the PAG and the rostral ventromedial medulla pain circuit.

    “The integrated freeze response includes an opioid-mediated analgesia,28,29 which is itself mediated by the PAG and the rostral ventromedial medulla pain circuit.71”

    From Fear and the Defense Cascade (2015) · cites this paper as [29]

  • In predator-prey interactions, attentive immobility functions to decrease the likelihood of detection since the visual cortex of mammalian carnivores is programmed to detect moving objects.

    “In predator-prey interactions, this attentive immobility functions to decrease the likelihood of detection since the visual cortex of mammalian carnivores is programmed to detect moving objects.16”

    From Fear and the Defense Cascade (2015) · cites this paper as [16]

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Authors
da Silva, L. F. S., Coimbra, N. C., & Menescal-de-Oliveira, L.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Menescal-de-Oliveira, Leda
ORCID
Coimbra, Norberto Cysne
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2012-08
Volume
233
Issue
2
Pages
422-427
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2012.05.020
OpenAlex
W1973166513
Cited by
11
References
31
Citations by year
2023: 1 · 2022: 1 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
rostral ventromedial medulla, antinociception, tonic immobility, cholinergic modulation, carbachol, lidocaine, nociception, guinea pig
MeSH terms
Analysis of Variance, Anesthetics, Local, Animals, Biophysics, Biotin, Carbachol, Dextrans, Electric Stimulation, Guinea Pigs, Lidocaine, Male, Medulla Oblongata, Neural Pathways, Pain Measurement, Pons, Vocalization, Animal, Analgesics, Non-Narcotic, Immobility Response, Tonic, Nociception

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