Exposure to nicotine enhances its subsequent self-administration: Contribution of nicotine-associated contextual stimuli
Open accessAbstract
Contextual stimuli present during nicotine exposure can come to act as conditioned stimuli and have been shown to play an important role in ongoing nicotine self-administration. In the present study, we characterized the effects of contextual stimuli previously paired with non-contingent nicotine exposure injections on subsequent nicotine self-administration. Rats were exposed to five injections of either saline or nicotine (0.4 mg/kg, i.p.) in either their home cage or a self-administration chamber with the levers retracted. Two weeks later, they were allowed to self-administer nicotine (30 μg/kg/infusion, IV) under fixed ratio (FR) schedules of reinforcement across 12 consecutive sessions. Lastly, responding under a progressive ratio (PR) schedule was assessed. Rats exposed to nicotine in the self-administration chamber subsequently increased their intake of nicotine across the FR test days, obtaining more infusions on average by days 7-12 compared to their saline exposed controls. This increase was not due to nicotine exposure alone as rats exposed to nicotine in the home cage did not show this effect. It was also not due to differences in the final ratio achieved between nicotine and saline exposed rats. Although rats exposed to nicotine in the self-administration chambers displayed reduced discrimination between the active and inactive levers during FR testing, they showed increased motivation to self-administer nicotine under the PR schedule. These results indicate that exposure to nicotine can enhance its subsequent self-administration and highlight the contribution of nicotine-associated contextual stimuli to the work output rats ultimately emit to obtain the drug.
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Exposure to nicotine increases its subsequent self-administration, which is further enhanced by nicotine-paired cues.
“Exposure to nicotine also increases its subsequent self-administration, which is further enhanced by nicotine-paired cues (Neugebauer, Cortright, Sampedro, & Vezina, 2014).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Neugebauer, Cortright, Sampedro, & Vezina, 2014
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- Authors
- Neugebauer, N. M., Cortright, J. J., Sampedro, G. R., & Vezina, P.
- Affiliations
- University of Chicago (US)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 260
- Pages
- 155-161
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC3935320
- OpenAlex
- W2153794168
- Cited by
- 12
- References
- 48
- Citations by year
- 2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA009397, P01DA019695, T32DA007255)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, nicotine self-administration, contextual cues, conditioned stimulus, fixed-ratio schedules, progressive ratio schedule, drug motivation, work output, rats
- MeSH terms
- Animals, Conditioning, Operant, Cues, Discrimination, Psychological, Housing, Animal, Male, Motivation, Nicotine, Reinforcement Schedule, Reward, Self Administration, Space Perception, Time Factors, Nicotinic Agonists, Rats, Long-Evans, Rats, Drug-Seeking Behavior
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