Cited by 194Flavonoids in Medical ResearchMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

Luteolin Protects against High Fat Diet-Induced Cognitive Deficits in Obesity Mice

Liu, Yi, Fu, Xiaobin, Lan, Nuo, Li, Sai, Zhang, Jingzheng, Wang, Shuaishuai, Li, Cheng, Shang, Yanguo +2 more·2014·Behavioural Brain Research

Abstract

The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the numerous elucidations on the impact of obesity on cognition decline, the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized into four groups treated with their respective diets for 4 weeks including control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat diet+luteolin (HFDL). The dose of luteolin was 10mg/kg, oral. We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. Importantly, we showed that luteolin treatment had the effects of alleviating neuroinflammation, oxidative stress and neuronal insulin resistance in the mouse brain, restored blood adipocytokines level to normal. Furthermore, luteolin increased the level of brain-derived neurotrophic factor (BDNF), the action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the cortex and hippocampus as to that the behavioral performance in Morris water maze (MWM) and step-through task were significantly improved. These results indicate a previously unrecognized potential of luteolin in alleviating obesity-induced cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD).

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Crossref · 10.1016/j.bbr.2014.02.040

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Authors
Liu, Y., Fu, X., Lan, N., Li, S., Zhang, J., Wang, S., Li, C., Shang, Y., Huang, T., & Zhang, L.
Affiliations
Xuzhou Medical College (CN)
Corresponding author
Liu, Yi
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2014-07
Volume
267
Pages
178-188
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2028247429
Cited by
194
References
55
Citations by year
2026: 5 · 2025: 17 · 2024: 15 · 2023: 19 · 2022: 22 · 2021: 20 · 2020: 24 · 2019: 19 · 2018: 12 · 2017: 13 · 2016: 15 · 2015: 10 · 2014: 1 · 2013: 1
FWCI
9.54
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • LifeScan
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
luteolin, obesity, high-fat diet, cognitive impairment, neuroinflammation, oxidative stress, adipokines, brain-derived neurotrophic factor, synapsin I, PSD-95, glucose metabolism, type 2 diabetes, Alzheimer's disease, hippocampus, cortex
MeSH terms
Disks Large Homolog 4 Protein, Animals, Blood Glucose, Brain, Cognition Disorders, Eating, Insulin Resistance, Male, Membrane Proteins, Mice, Inbred C57BL, Neurons, Obesity, Neuroimmunomodulation, Weight Gain, Cytokines, Synapsins, Oxidative Stress, Maze Learning, Brain-Derived Neurotrophic Factor, Anti-Obesity Agents, Luteolin, Guanylate Kinases, Adipokines, Diet, High-Fat

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