Type II diabetes in mild cognitive impairment and Alzheimer’s disease: Results from a prospective population-based study in Germany
Abstract
Diabetes mellitus type 2 (T2DM) is considered to be an important risk factor for mild cognitive impairment (MCI) and subsequent Alzheimer's disease (AD). The majority of studies relating T2DM to MCI and AD were performed in North America. We investigated the potential impact of T2DM on the development of MCI and AD in the Interdisciplinary Longitudinal Study on Adult Development and Aging which involves a representative birth cohort of subjects born between 1930 and 1932 in Germany. Subjects received a thorough psycho-geriatric examination and neuropsychological testing; particular care was taken to exclude subjects with severe medical or neurological conditions sufficient to explain the cognitive deficits, or other major psychiatric disorders. When compared to healthy subjects (n=159), patients with MCI (n=108) or AD (n=26) showed a tendency towards increased prevalence rates for T2DM (17% vs. 23%; chi2=1.7, p=0.18). In both patients with MCI and controls, T2DM was associated with psychomotor slowing but not deficits in other cognitive domains typically involved in MCI. Our findings indicate that T2DM is involved in MCI and may aggravate the clinical picture as a concomitant factor.
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Type 2 diabetes patients have an elevated risk for Alzheimer's disease and manifest deficient CNS insulin signaling, likely because of decreased insulin uptake into the brain following sustained peripheral hyperinsulinemia.
“an elevated risk for AD also exists in type 2 diabetes patients, who manifest deficient CNS insulin signaling (Matsuzaki et al., 2010; Ott et al., 1999; Toro et al., 2009; Watson and Craft, 2003), likely as a consequence of decreased insulin uptake into the brain following sustained peripheral hyperinsulinemia (Gerozissis et al., 1993; Kaiyala et al., 2000; Schwartz et al., 1990).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Toro et al., 2009
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- Authors
- Toro, P., Schönknecht, P., & Schröder, J.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Schröder, Johannes
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2009-04-17
- Volume
- 16
- Issue
- 4
- Pages
- 687-691
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2113814333
- Cited by
- 71
- References
- 14
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 8 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- type 2 diabetes, mild cognitive impairment
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Germany, Humans, Longitudinal Studies, Male, Mental Status Schedule, Neuropsychological Tests, Risk Factors, Multivariate Analysis, Community Health Planning
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