Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice

Domingues, Micaela; Casaril, Angela Maria; Birmann, Paloma Taborda; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Vieira, Beatriz M.; Dapper, Luiz H.; Lenardão, Eder J.; Sonego, Mariana; Collares, Tiago; Seixas, Fabiana K.; Brüning, César Augusto; Savegnago, Lucielli

doi:10.1016/j.bbr.2019.03.021

Cited by 64Treatment of Major DepressionTryptophan and brain disordersStress Responses and Cortisol

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice

Domingues, Micaela, Casaril, Angela Maria, Birmann, Paloma Taborda, Bampi, Suely Ribeiro, Lourenço, Darling de Andrade, Vieira, Beatriz M., Dapper, Luiz H., Lenardão, Eder J. +5 more·2019·Behavioural Brain Research

DOI 10.1016/j.bbr.2019.03.021

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Abstract

In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1,2-a] pyridine (MPI; 1, 10 or 50 mg/kg, i.g.) on the acute restraint stress (ARS)-induced depressive- and anxiety-like behaviors in mice and its underlying mechanism of action. We used the open filed test, forced swimming test, and splash test to evaluate depressive-like behavior, and marble burying and elevated plus maze test to measure anxiety-like behavior. We found that MPI attenuated ARS-induced depressive- and anxiety-like behaviors in all behavioral tests, without having an effect in non-stressed mice. MPI prevented the increased in pro-inflammatory cytokines, indoleamine-2,3-dioxygenase (IDO) and inducible nitric oxide synthase (iNOS) expression in brain structures via canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) down-regulation. Additionally, MPI prevented ARS-induced downregulation of brain-derived neurotrophic factor (BDNF), increased reactive oxygen/nitrogen species generation and lipid peroxidation in prefrontal cortex and hippocampus of mice. In addition, MPI blocked the downregulation of glucocorticoid receptors in the prefrontal cortex and hippocampus and reduced the increased circulating level of corticosterone in stressed mice. These results suggested that MPI showed antidepressant- and anxiolytic-like properties and the effects might be associated with the biological changes in the prefrontal cortex and hippocampus.

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From Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model (2022) · cites this paper as [31]

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Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model
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Authors: Domingues, M., Casaril, A. M., Birmann, P. T., Bampi, S. R., Lourenço, D. D. A., Vieira, B. M., Dapper, L. H., Lenardão, E. J., Sonego, M., Collares, T., Seixas, F. K., Brüning, C. A., & Savegnago, L.
Affiliations: Universidade Federal de Pelotas (BR)
Corresponding author: Brüning, César Augusto
Savegnago, Lucielli
ORCID: Domingues, Micaela
Casaril, Angela Maria
Birmann, Paloma Taborda
Bampi, Suely Ribeiro
Lourenço, Darling de Andrade
Vieira, Beatriz M.
Collares, Tiago
Seixas, Fabiana K.
Brüning, César Augusto
Savegnago, Lucielli
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2019-07
Volume: 366
Pages: 96-107
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2019.03.021
OpenAlex: W2922442784
Cited by: 64
References: 48
Citations by year: 2026: 6 · 2025: 11 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 3
FWCI: 4.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃ³gico
CoordenaÃ§Ã£o de AperfeiÃ§oamento de Pessoal de NÃvel Superior
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: selenium compounds, acute restraint stress, depression-like behavior, anxiety-like behavior, antidepressant-like effects, anxiolytic-like effects, inflammatory cytokines, indoleamine 2,3-dioxygenase, inducible nitric oxide synthase, NF-κB signaling, brain-derived neurotrophic factor, oxidative stress, lipid peroxidation, glucocorticoid receptor, corticosterone, prefrontal cortex, hippocampus
MeSH terms: Animals, Antidepressive Agents, Anxiety, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Hippocampus, Imidazoles, Male, Pyridines, Receptors, Glucocorticoid, Restraint, Physical, Selenium, Stress, Psychological, Anti-Anxiety Agents, Lipid Peroxidation, NF-kappa B, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Mice, Nitric Oxide Synthase Type II

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Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice

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