Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus
Abstract
Modulation of hippocampal synaptic plasticity by glucocorticoids has been attracting much attention, due to its importance in stress responses. Dendritic spines are essential for memory storage processes. Here, we investigated the effect of dexamethasone (DEX), a specific agonist of glucocorticoid receptor (GR), on density and morphology of dendritic spines in adult male rat hippocampus by imaging of Lucifer Yellow-injected spines in slices. The application of 100 nM DEX (stressful high concentration) induced rapid modulation of the density and morphology of dendritic spines in CA1 pyramidal neurons within 1h. The total spine density increased from 0.88 spines/microm (control) to 1.36 spines/microm (DEX-treated). DEX significantly increased the density of thin and mushroom type spines, however only a slight increase was observed for stubby and filopodium type spines. Because the presence of 10 microM cycloheximide, an inhibitor of protein synthesis, did not suppress the DEX effect, these responses are probably non-genomic. Western immunoblot analysis demonstrated the localization of classical type GR in Triton-insoluble synaptosomal fractions (enriched in postsynaptic membranes) from hippocampal slices, suggesting a possible action site of DEX at spines.
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Neurotransmitters such as acetylcholine, GABA, and serotonin produced by bacteria belonging to Lactobacillus, Bifidobacteria, Enterococcus, and Streptococcus species can influence brain cell physiology directly and indirectly.
“Neurotransmitters, such as acetylcholine, GABA, and serotonin, produced by bacteria belonging to Lactobacillus, Bifidobacteria, Enterococcus, and Streptococcus species, can influence brain cell physiology directly and indirectly (11, 85, 86).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [86]
Cites
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212 · see citing works
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024 · see citing works
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works
Shors, T. J., Chua, C., & Falduto, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06292.2001 · Cited by 496 · see citing works
Prolonged Ca 2+ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats
Landfield, P. W., & Pitler, T. A. (1984) · Science · doi:10.1126/science.6494926 · Cited by 495 · see citing works
Morimoto, M., Morita, N., Ozawa, H., Yokoyama, K., & Kawata, M. (1996) · Neuroscience Research · doi:10.1016/s0168-0102(96)01105-4 · Cited by 475 · see citing works
Towle, A. C., & Sze, P. Y. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)90079-1 · Cited by 351 · see citing works
Roozendaal, B., Griffith, Q. K., Buranday, J., de Quervain, D. J.-F., & McGaugh, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337480100 · Cited by 291 · see citing works
Controversies surrounding glucocorticoid-mediated cell death in the hippocampus
Reagan, L. P., & McEwen, B. S. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)00031-8 · Cited by 254 · see citing works
Han, F., Ozawa, H., Matsuda, K., Nishi, M., & Kawata, M. (2005) · Neuroscience Research · doi:10.1016/j.neures.2004.12.013 · Cited by 178 · see citing works
Roozendaal, B., Phillips, R. G., Power, A. E., Brooke, S. M., Sapolsky, R. M., & McGaugh, J. L. (2001) · Nature Neuroscience · doi:10.1038/nn766 · Cited by 160 · see citing works
Alfarez, D. N., Wiegert, O., Joëls, M., & Krugers, H. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00483-9 · Cited by 142 · see citing works
Shibuya, K., Takata, N., Hojo, Y., Furukawa, A., Yasumatsu, N., Kimoto, T., Enami, T., Suzuki, K., Tanabe, N., Ishii, H., et al. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00489-0 · Cited by 140 · see citing works
Ballard, P. L., CARTER, J. P., GRAHAM, B. S., & Baxter, J. D. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-2-290 · Cited by 135 · see citing works
Glucocorticoid Endangerment of the Hippocampus: Tissue, Steroid and Receptor Specificity
Packan, D. R., & Sapolsky, R. M. (2008) · Neuroendocrinology · doi:10.1159/000125400 · Cited by 132 · see citing works
Corticosterone reduces the excitability of hippocampal pyramidal cells in vitro.
Vidal, C., Jordan, W., & ̈nsberger, W. Z. (1986) · Brain Research · doi:10.1016/0006-8993(86)90007-7 · Cited by 123 · see citing works
Nair, S. M., Werkman, T. R., Craig, J. C., Finnell, R. H., Joëls, M., & Eberwine, J. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02685.1998 · Cited by 122 · see citing works
Marinesco, S., Bonnet, C., & Cespuglio, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00045-7 · Cited by 110 · see citing works
Nishi, M., Ogawa, H., Ito, T., Matsuda, K., & Kawata, M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0659 · Cited by 108 · see citing works
Shors, T. J., Falduto, J., & Leuner, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03065.x · Cited by 105 · see citing works
Regulation of dendritic spine stability
Smart, F. M., & Halpain, S. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:5 · Cited by 93 · see citing works
Liposits, Z., & Bohn, M. C. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350103 · Cited by 85 · see citing works
Duan, H., Wearne, S. L., Morrison, J. H., & Hof, P. R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00305-6 · Cited by 78 · see citing works
Asaki, C., Usuda, N., Nakazawa, A., Kametani, K., & Suzuki, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02523-x · Cited by 78 · see citing works
Sato, S., Osanai, H., Monma, T., Harada, T., Hirano, A., Saito, M., & Kawato, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.168 · Cited by 47 · see citing works
Binding characteristics of glucocorticoid receptor in synaptic plasma membrane from rat brain.
Guo, Z., Chen, Y., Xu, R.-B., & Fu, H. (1995) · PubMed · Cited by 44 · see citing works
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The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Stress and Memory: Behavioral Effects and Neurobiological Mechanisms
Sandi, C., & Pinelo-Nava, M. T. (2007) · Neural Plasticity · doi:10.1155/2007/78970 · Cited by 611 · see citing works
Rapid non-genomic effects of corticosteroids and their role in the central stress response
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0472 · Cited by 414 · see citing works
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289 · see citing works
Bagot, R. C., van Hasselt, F. N., Champagne, D. L., Meaney, M. J., Krugers, H. J., & Joëls, M. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.03.004 · Cited by 216 · see citing works
Haller, J., Mikics, É., & Makara, G. B. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.004 · Cited by 201 · see citing works
Mucha, M. W., Skrzypiec, A. E., Schiavon, E., Attwood, B. K., Kucerova, E., & Pawlak, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107936108 · Cited by 189 · see citing works
Estrogen synthesis in the brain—Role in synaptic plasticity and memory
Hojo, Y., Murakami, G., Mukai, H., Higo, S., Hatanaka, Y., Ogiue-Ikeda, M., Ishii, H., Kimoto, T., & Kawato, S. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.04.017 · Cited by 214 · see citing works
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175 · see citing works
“There is electron microscopy and neurochemical evidence for GR localization to neuronal membranes, in particular postsynaptic membranes, supporting an alternative role for the so-called nuclear receptor (Johnson et al. 2005; Komatsuzaki et al. 2005; Wang and Wang 2009; Prager et al. 2010).”
Kato, A., Hojo, Y., Higo, S., Komatsuzaki, Y., Murakami, G., Yoshino, H., Uebayashi, M., & Kawato, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00149 · Cited by 165 · see citing works
Modulation of synaptic plasticity by brain estrogen in the hippocampus
Mukai, H., Kimoto, T., Hojo, Y., Kawato, S., Murakami, G., Higo, S., Hatanaka, Y., & Ogiue‐Ikeda, M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.002 · Cited by 150 · see citing works
Novel Aspects of Glucocorticoid Actions
Uchôa, E. T., Aguilera, G., Herman, J. P., Fiedler, J. L., Deak, T., & de Sousa, M. B. C. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12157 · Cited by 144 · see citing works
Are BDNF and glucocorticoid activities calibrated?
Jeanneteau, F. D., & Chao, M. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.017 · Cited by 141 · see citing works
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 120 · see citing works
Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen
Ooishi, Y., Kawato, S., Hojo, Y., Hatanaka, Y., Higo, S., Murakami, G., Komatsuzaki, Y., Ogiue-Ikeda, M., Kimoto, T., & Mukai, H. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.10.004 · Cited by 133 · see citing works
Ogiue-Ikeda, M., Tanabe, N., Mukai, H., Hojo, Y., Murakami, G., Tsurugizawa, T., Takata, N., Kimoto, T., & Kawato, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.010 · Cited by 119 · see citing works
Simms, J. A., Haass-Koffler, C. L., Bito-Onon, J., Li, R., & Bartlett, S. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.268 · Cited by 97 · see citing works
Hojo, Y., Higo, S., Kawato, S., Hatanaka, Y., Ooishi, Y., Murakami, G., Ishii, H., Komatsuzaki, Y., Ogiue-Ikeda, M., Mukai, H., et al. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00043 · Cited by 86 · see citing works
Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish
Marco, R. J. D., Groneberg, A. H., Yeh, C.-M., Ramírez, L. A. C., & Ryu, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00082 · Cited by 85 · see citing works
Murakami, G., Tsurugizawa, T., Hatanaka, Y., Komatsuzaki, Y., Tanabe, N., Mukai, H., Hojo, Y., Kominami, S. A. J., Yamazaki, T., Kimoto, T., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.066 · Cited by 84 · see citing works
Learning under stress: A role for the neural cell adhesion molecule NCAM
Bisaz, R., Conboy, L., & Sandi, C. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.11.003 · Cited by 83 · see citing works
The effects of hormones and physical exercise on hippocampal structural plasticity
Triviño-Paredes, J., Patten, A. R., Gil‐Mohapel, J., & Christie, B. R. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.001 · Cited by 83 · see citing works
Deng, Q., Riquelme, D., Trinh, L., Low, M. J., Tomić, M., Stojilkovic, S., & Aguilera, G. (2015) · Endocrinology · doi:10.1210/en.2015-1265 · Cited by 77 · see citing works
Local amplification of glucocorticoids in the aging brain and impaired spatial memory
Yau, J. L. W., & Seckl, J. R. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00024 · Cited by 77 · see citing works
McLaughlin, K. J., Wilson, J. O., Harman, J. S., Wright, R. L., Wieczorek, L., Gomez, J. L., Korol, D. L., & Conrad, C. D. (2009) · Hippocampus · doi:10.1002/hipo.20678 · Cited by 77 · see citing works
Conrad, C. D., & Bimonte‐Nelson, H. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82002-3 · Cited by 75 · see citing works
Neeley, E. W., Berger, R., Koenig, J. I., & Leonard, S. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.065 · Cited by 71 · see citing works
Komatsuzaki, Y., Hatanaka, Y., Murakami, G., Mukai, H., Hojo, Y., Saito, M., Kimoto, T., & Kawato, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034124 · Cited by 67 · see citing works
Rimmerman, N., Schottlender, N., Reshef, R., Dan-Goor, N., & Yirmiya, R. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.023 · Cited by 65 · see citing works
Glucocorticoid Receptors are Localized to Dendritic Spines and Influence Local Actin Signaling
Jafari, M., Seese, R. R., Babayan, A. H., Gall, C. M., & Lauterborn, J. C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8288-3 · Cited by 61 · see citing works
Bello-Medina, P. C., Flores, G., Quirarte, G. L., McGaugh, J. L., & Prado-Alcalá, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613680113 · Cited by 60 · see citing works
Tsurugizawa, T., Mukai, H., Tanabe, N., Murakami, G., Hojo, Y., Kominami, S. A. J., Mitsuhashi, K., Komatsuzaki, Y., Morrison, J. H., Janssen, W. G. M., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.188 · Cited by 58 · see citing works
Shaqura, M. A., Li, X., Al‐Khrasani, M., Shakibaei, M., Tafelski, S., Fürst, S., Beyer, A., Kawata, M., Schäfer, M., & Mousa, S. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.019 · Cited by 57 · see citing works
Rainville, J. R., Pollard, K., & Vasudevan, N. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00018 · Cited by 7 · see citing works
Hillerer, K. M., Slattery, D. A., & Pletzer, B. A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100796 · Cited by 47 · see citing works
Murakami, G., Hojo, Y., Kato, A., Komatsuzaki, Y., Horie, S., Soma, M., Kim, J., & Kawato, S. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12561 · Cited by 45 · see citing works
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein?
Radulovic, J., & Tronson, N. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.008 · Cited by 49 · see citing works
Dendritic spines in the posterodorsal medial amygdala after restraint stress and ageing in rats
Marcuzzo, S., Dall’Oglio, A., Ribeiro, M. F. M., Achaval, M., & Rasia‐Filho, A. A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.019 · Cited by 40 · see citing works
The emerging role of exosomes in communication between the periphery and the central nervous system
Han, W., Zhang, H., Feng, L., Dang, R., Wang, J., Cui, C., & Jiang, P. (2023) · MedComm · doi:10.1002/mco2.410 · Cited by 38 · see citing works
Non-receptor-tyrosine Kinases Integrate Fast Glucocorticoid Signaling in Hippocampal Neurons
Yang, S., Roselli, F., Patchev, A. V., Yu, S., & Almeida, O. F. X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470146 · Cited by 40 · see citing works
Endogenous Synthesis of Corticosteroids in the Hippocampus
Higo, S., Hojo, Y., Ishii, H., Komatsuzaki, Y., Ooishi, Y., Murakami, G., Mukai, H., Yamazaki, T., Nakahara, D., Barron, A. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021631 · Cited by 39 · see citing works
Yoshiya, M., Komatsuzaki, Y., Hojo, Y., Ikeda, M., Mukai, H., Hatanaka, Y., Murakami, G., Kawata, M., Kimoto, T., & Kawato, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00191 · Cited by 38 · see citing works
Kil, S., & Kalinec, F. (2013) · Hearing Research · doi:10.1016/j.heares.2013.01.020 · Cited by 37 · see citing works
Orłowski, D., Elfving, B., Müller, H. K., Wegener, G., & Bjarkam, C. R. (2012) · Stress · doi:10.3109/10253890.2011.643516 · Cited by 33 · see citing works
Ooishi, Y., Mukai, H., Hojo, Y., Murakami, G., Hasegawa, Y., Shindo, T., Morrison, J. H., Kimoto, T., & Kawato, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr164 · Cited by 31 · see citing works
Rapid signaling of steroid hormones in the vertebrate nervous system
Sakamoto, H. (2011) · Frontiers in bioscience · doi:10.2741/3970 · Cited by 29 · see citing works
Lauterborn, J. C., Jafari, M., Babayan, A. H., & Gall, C. M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht249 · Cited by 29 · see citing works
Quarantelli, M., Giardino, G., Prinster, A., Aloj, G., Carotenuto, B., Cirillo, E., Marsili, A., Salvatore, E., GIUDICE, E. D., & Pignata, C. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2012.06.002 · Cited by 26 · see citing works
Ayrout, M., Simon, V., Bernard, V., Binart, N., Cohen-Tannoudji, J., Lombès, M., & Chauvin, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-01777-2 · Cited by 26 · see citing works
Factoring neurotrophins into a neurite-based pathophysiological model of schizophrenia
Bellon, A., Krebs, M., & Jay, T. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.003 · Cited by 26 · see citing works
Ghasemzadeh, Z., & Rezayof, A. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.015 · Cited by 24 · see citing works
Giardino, G., Fusco, A., Romano, R., Gallo, V., Maio, F. D., Esposito, T., Palamaro, L., Parenti, G., Salerno, M., Vajro, P., et al. (2012) · European Journal of Neurology · doi:10.1111/ene.12024 · Cited by 23 · see citing works
Deng, Q., Waxse, B. J., Riquelme, D., Zhang, J., & Aguilera, G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.044 · Cited by 21 · see citing works
Yang, N., Zhang, Y., Wang, J.-T., Chen, C., Song, Y., Liang, J., Ma, D., & Zhang, Y.-F. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.44927 · Cited by 16 · see citing works
Shaping Memories via Stress: A Synaptic Engram Perspective
Brosens, N., Lesuis, S. L., Rao‐Ruiz, P., van den Oever, M. C., & Krugers, H. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.008 · Cited by 16 · see citing works
Barr, J. L., Bray, B., & Forster, G. L. (2018) · InTech eBooks · doi:10.5772/intechopen.70854 · Cited by 13 · see citing works
Duan, J., Pandey, S., Li, T., Castellano, D., Gu, X., Li, J., Tian, Q., & Lü, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00217 · Cited by 13 · see citing works
Zhang, L.-L., Wei, X., Zhang, Y.-H., Xu, S., Chen, X., Wang, C., & Wang, Q. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.023 · Cited by 13 · see citing works
González-Franco, D. A., Bello-Medina, P. C., Serafín, N., Prado-Alcalá, R. A., & Quirarte, G. L. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.06.005 · Cited by 12 · see citing works
Medina, A. C., García, M. E. T., Rodríguez–Serrano, L. M., Bello-Medina, P. C., Quirarte, G. L., McGaugh, J. L., & Prado-Alcalá, R. A. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107092 · Cited by 11 · see citing works
Espino, L. A. V., Gómez, A. B. S., & Durán, D. A. B. (2019) · Synapse · doi:10.1002/syn.22140 · Cited by 11 · see citing works
Yang, N., Li, Y., Xiong, T., Chen, L.-M., Zhai, Y., Liang, J., Hao, Y., Ma, D., & Zhang, Y.-F. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.04.009 · Cited by 9 · see citing works
Stress Adaptation and the Hypothalamic‐Pituitary‐Adrenal Axis
Aguilera, G. (2016) · Wiley eBooks · doi:10.1002/9781118760369.ch17 · Cited by 8 · see citing works
Cortez, C. M., Cruz, F. A. D. O., & Silva, D. (2008) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-89132008000700003 · Cited by 7 · see citing works
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1159-9 · Cited by 7 · see citing works
Imbalance in cerebral protein homeostasis: Effects on memory consolidation.
Prado-Alcalá, R., González-Salinas, S., Antaramián, A., Quirarte, G., Bello-Medina, P. C., & Medina, A. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112767 · Cited by 7 · see citing works
Halimi, H., Ahmadi, B., Asri, N., Rostami‐Nejad, M., & Houri, H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107363 · Cited by 6 · see citing works
Martínez-Degollado, M., Medina, A. C., Bello-Medina, P. C., Quirarte, G. L., & Prado-Alcalá, R. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305066 · Cited by 3 · see citing works
Tan, R., Han, C., Sun, D., Zhang, X., Liu, T., Sun, H., & Wang, Z. (2025) · Medicine · doi:10.1097/md.0000000000042925 · Cited by 3 · see citing works
Olsen, L. K., Jones, K. A., Moore, R. J., McCubbins, H., Curtner, F. S., Sharma, B., & Hatcher-Solis, C. N. (2025) · Frontiers in Sleep · doi:10.3389/frsle.2025.1611192 · Cited by 2 · see citing works
Regulation of synaptic plasticity by hippocampus synthesized estradiol
Barron, A. M., Hojo, Y., Mukai, H., Higo, S., Ooishi, Y., Hatanaka, Y., Ogiue‐Ikeda, M., Murakami, G., Kimoto, T., & Kawato, S. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.118 · Cited by 2 · see citing works
Gómez, A. B. S. (2014) · Clinical and Experimental Pharmacology · doi:10.4172/2161-1459.1000161 · Cited by 2 · see citing works
Aguilera, G. (2015) · Interdisciplinary Information Sciences · doi:10.4036/iis.2015.b.13 · Cited by 2 · see citing works
Involvement of kinases in memory consolidation of inhibitory avoidance training
Montiel, I., Bello-Medina, P. C., Prado-Alcalá, R. A., Quirarte, G. L., Verdín-Ruvalcaba, L. A., Marín-Juárez, T. A., & Medina, A. C. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0093 · Cited by 1 · see citing works
Tsiarli, M. A. (2014) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1 · see citing works
Dendritic Morphology of Developing Hippocampal Neurons in Cyp11a1 Null Mice
Jiang, H.-H., Wu, T.-H., Lee, L., Lee, J.-C., Chung, B., Yang, F.-M., & Hu, M. (2024) · Developmental Neuroscience · doi:10.1159/000540106 · Cited by 1 · see citing works
Local Production of Estrogen and its Rapid Modulatory Action on Synaptic Plasticity
Kawato, S., Hojo, Y., Mukai, H., Murakami, G., Ogiue‐Ikeda, M., Ishii, H., & Kimoto, T. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6854-6_7 · Cited by 1 · see citing works
Brunello, C. A., Ortiz, M. G., Muñoz, P. P., Araújo, J. P., Pajuelo, J. E. C., Marti, J. C. A., Lyytikäinen, E., Hansen, M., Tonelli, S., Didio, G., et al. (2026) · Journal of Biological Chemistry · doi:10.64898/2026.04.08.717148 · Cited by 1 · see citing works
Lewitus, G. M., Schwartz‐Stav, O., & Schwartz, M. (2009) · doi:10.1002/9783527628346.ch12
Mery, L., Wayner, M. J., McQuade, J., & Anderson, E. (2007)
Rapid neuronal signaling cascades initiated by corticosterone
Yang, Silei, Landgraf, R., Geigenberger, P., Yang, B., & Liu, P. J. (2012)
Udeh‐Momoh, C. T., Yi, J. H., Piers, T. M., Waite, E., Whitehead, G., Whitcomb, D. J., Lightman, S. L., Cho, K. K., & Conway-Campbell, B. L. (2021) · Research Square · doi:10.21203/rs.3.rs-923210/v1
Olsen, L. K., Jones, K. A., Moore, R. J., McCubbins, H., Curtner, F. S., Sharma, B., & Hatcher-Solis, C. N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.648374
Intense training abolishes the two temporal windows of cycloheximide-induced amnesia in rats
Medina, A. C., Bello-Medina, P. C., Quirarte, G. L., & Prado-Alcalá, R. A. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150258
- Authors
- Komatsuzaki, Y., Murakami, G., Tsurugizawa, T., Mukai, H., Tanabe, N., Mitsuhashi, K., Kawata, M., Kimoto, T., Ooishi, Y., & Kawato, S.
- Affiliations
- Meiji University (JP)
- Japan Science and Technology Agency (JP)
- Kyoto Prefectural University of Medicine (JP)
- Corresponding author
- Kawato, Suguru
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 335
- Issue
- 4
- Pages
- 1002-1007
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2090423881
- Cited by
- 87
- References
- 26
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 9
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- glucocorticoid receptor, dexamethasone, dendritic spines, spine density, dendritic spine morphology, pyramidal neurons, hippocampus, CA1, synaptic plasticity, stress response, postsynaptic membrane, synaptosomes
- MeSH terms
- Animals, Cells, Cultured, Dexamethasone, Dose-Response Relationship, Drug, Hippocampus, Male, Neuronal Plasticity, Receptors, Glucocorticoid, Rats, Wistar, Pyramidal Cells, Cell Enlargement, Dendritic Spines, Rats
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