Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons

In hippocampal glutamatergic neurons, BPA binds membrane-associated ERα and, even at low concentrations (10-100 nM), rapidly increases intracellular Ca2+ and activates ERK/MAP kinase signaling.

“In hippocampal glutamatergic neurons, BPA binds membrane-associated ERα and, even at low concentrations (10–100 nM), rapidly increases intracellular Ca2+ and activates ERK/MAP kinase signaling (Gould et al., 1998; Ogiue-Ikeda et al., 2008).”

These receptor- and hormone-dependent disturbances are functionally reflected in electrophysiological deficits, including reduced hippocampal and dentate gyrus LTP after developmental exposure to Aroclor 1254 or CB-77.

“These receptor- and hormone-dependent disturbances are functionally reflected in electrophysiological deficits, including reduced hippocampal and dentate gyrus LTP after developmental exposure to Aroclor 1254 or CB-77 (Gilbert and Crofton, 1999; Ogiue-Ikeda et al., 2008; Zoeller et al., 2000).”

Bisphenols induce rapid increases in intracellular Ca2+ via membrane-associated estrogen receptor signaling, mimicking endogenous estrogenic effects in a dysregulated manner that may disturb normal synaptic modulation.

“Bisphenols, for example, induce rapid increases in intracellular Ca2+ via membrane-associated estrogen receptor signaling, thereby mimicking endogenous estrogenic effects, but in a dysregulated manner that may disturb normal synaptic modulation (Ogiue-Ikeda et al., 2008).”

Xenoestrogenic effects on synaptic structure are dose-, context-, and region-dependent.

“In vivo, however, moderate BPA exposure reduced spine density and prevented estradiol-induced synaptogenesis in the hippocampus and prefrontal cortex, indicating that xenoestrogenic effects on synaptic structure are dose-, context-, and region-dependent (Ogiue-Ikeda et al., 2008; Rodrigues et al., 2024; Weiss, 2007).”

In vivo, moderate BPA exposure reduced spine density and prevented estradiol-induced synaptogenesis in the hippocampus and prefrontal cortex.

“In vivo, however, moderate BPA exposure reduced spine density and prevented estradiol-induced synaptogenesis in the hippocampus and prefrontal cortex, indicating that xenoestrogenic effects on synaptic structure are dose-, context-, and region-dependent (Ogiue-Ikeda et al., 2008; Rodrigues et al., 2024; Weiss, 2007).”

Exposure to BPA at low concentrations (10-100 nM) rapidly enhanced LTD in CA1 and CA3 of hippocampus.

“Interestingly, it has been reported that exposure to BPA at low concentrations (10–100 nM) rapidly enhanced LTD in CA1 and CA3 but suppressed LTD in the dentate gyrus of the hippocampus [20, 21].”

Exposure to BPA at low concentrations (10-100 nM) rapidly suppressed LTD in the dentate gyrus of hippocampus.

“Interestingly, it has been reported that exposure to BPA at low concentrations (10–100 nM) rapidly enhanced LTD in CA1 and CA3 but suppressed LTD in the dentate gyrus of the hippocampus [20, 21].”