Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 154

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway

Huang, Hao, Chang, Eun-Ju, Ryu, Jiyoon, Lee, Zang Hee, Lee, Youngkyun, Kim, Hong-Hee·2006·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2006.10.011
Open this paper in CoChat — free account

Abstract

The crucial role of p38 mitogen-activated protein kinase for osteoclast differentiation has been suggested from studies with specific pharmacological inhibitors and dominant-negative forms of p38. However, the targets through which p38 regulates osteoclast differentiation have not been clearly revealed. Here, we show that inhibition of p38 activity with SB203580 reduced osteoclastogenesis from primary precursor cells, with concomitant suppression in the induction of both c-Fos and nuclear factor of activated T cells (NFAT) c1 by receptor activator of nuclear factor kappaB ligand (RANKL), the key osteoclast differentiation factor. Overexpression of dominant-negative forms of p38 upstream kinases MKK3 and MKK6 elicited similar reduction in RANKL-stimulated elevation of c-Fos and NFATc1. Interestingly, overexpression of c-Fos restored RANKL-induced osteoclast differentiation from and NFATc1 expression in SB203580-treated precursor cells. Our results demonstrate a previously unknown function of the p38 pathway in up-regulating c-Fos and NFATc1 expression during RANKL-induced osteoclastogenesis.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbrc.2006.10.011

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 19

  1. Suda, 1999, Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families, Endocr. Rev., 20, 345, 10.1210/edrv.20.3.0367 · DOI
  2. Teitelbaum, 2000, Bone resorption by osteoclasts, Science, 289, 1504, 10.1126/science.289.5484.1504 · DOI · Paper page
  3. Lee, 2003, Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts, Biochem. Biophys. Res. Commun., 305, 211, 10.1016/S0006-291X(03)00695-8 · DOI
  4. Franzoso, 1997, Requirement for NF-kappaB in osteoclast and B-cell development, Genes Dev., 11, 3482, 10.1101/gad.11.24.3482 · DOI · Paper page
  5. Iotsova, 1997, Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2, Nat. Med., 3, 1285, 10.1038/nm1197-1285 · DOI
  6. Grigoriadis, 1994, c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling, Science, 266, 443, 10.1126/science.7939685 · DOI
  7. Ikeda, 2004, Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation, J. Clin. Invest., 114, 475, 10.1172/JCI200419657 · DOI · Paper page
  8. Jimi, 1999, Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function, J. Immunol., 163, 434, 10.4049/jimmunol.163.1.434 · DOI
  9. Lee, 2002, The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation, Bone, 30, 71, 10.1016/S8756-3282(01)00657-3 · DOI
  10. Li, 2002, p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function, Endocrinology, 143, 3105, 10.1210/endo.143.8.8954 · DOI
  11. Lee, 2000, Inhibition of p38 MAP kinase as a therapeutic strategy, Immunopharmacology, 47, 185, 10.1016/S0162-3109(00)00206-X · DOI
  12. Matsumoto, 2000, Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL), J. Biol. Chem., 275, 31155, 10.1074/jbc.M001229200 · DOI
  13. Li, 2003, p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages, Endocrinology, 144, 4999, 10.1210/en.2003-0166 · DOI
  14. Shin, 2002, A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6, J. Biol. Chem., 277, 8346, 10.1074/jbc.M110964200 · DOI
  15. Han, 1996, Characterization of the structure and function of a novel MAP kinase kinase (MKK6), J. Biol. Chem., 271, 2886, 10.1074/jbc.271.6.2886 · DOI
  16. Matsuo, 2004, Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos, J. Biol. Chem., 279, 26475, 10.1074/jbc.M313973200 · DOI · Paper page
  17. Tanos, 2005, Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light, J. Biol. Chem., 280, 18842, 10.1074/jbc.M500620200 · DOI
  18. Simi, 2005, Activation of c-fos by lipopolysaccharide in glial cells via p38 mitogen-activated protein kinase-dependent activation of serum or cyclic AMP/calcium response element, J. Neurochem., 92, 915, 10.1111/j.1471-4159.2004.02938.x · DOI
  19. Ichiki, 2003, Cyclic AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression, Hypertension, 42, 177, 10.1161/01.HYP.0000079791.26014.04 · DOI

Cited by

See all 154

Metadata

Authors
Huang, H., Chang, E.-J., Ryu, J., Lee, Z. H., Lee, Y., & Kim, H.-H.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2006-12
Volume
351
Issue
1
Pages
99-105
ISSN
0006-291X
DOI
10.1016/j.bbrc.2006.10.011
Cited by
154
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway. https://app.cochat.ai/papers/10.1016/j.bbrc.2006.10.011
The paper
Huang, H., Chang, E.-J., Ryu, J., Lee, Z. H., Lee, Y., & Kim, H.-H. (2006). Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2006.10.011

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.