Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
Abstract
In type 2 diabetes (T2DM) beta-cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) is reduced. In a model of T2DM, the VDF Zucker rat, GIP receptor mRNA and protein levels were shown to be down-regulated. Possible restoration of responsiveness to GIP in Zucker rats by reducing hyperglycemia has been examined. ZDF rats with extreme hyperglycemia demonstrated greater islet GIP receptor mRNA down-regulation (94.3+/-3.8%) than ZF rats (48.8+/-22.8%). GIP receptor mRNA levels in ZDF rats returned to 83.0+/-17.9% of lean following normalization of hyperglycemia by phlorizin treatment and pancreas perfusions demonstrated markedly improved GIP responsiveness. Treatment of VDF rats with a DP IV inhibitor (P32/98) resulted in improved glucose tolerance and restored sensitivity to GIP in isolated pancreata. These findings support the proposal that GIP receptor down-regulation in rodent T2DM is secondary to chronic hyperglycemia and that normalization of glycemia can restore GIP sensitivity.
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GIP receptors have been identified in adipose tissue, bone, and the brain.
“In addition to GIP's actions in the pancreatic beta cell, GIP receptors have been identified in adipose tissue, bone, and the brain (58).”
From New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics (2023) · cites this paper as [58]
Cites
Drucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896 · see citing works
The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210 · see citing works
Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651 · see citing works
Reduced incretin effect in Type 2 (non-insulin dependent) diabetes
Nauck, M., Stöckmann, F., Ebert, R., & Creutzfeldt, W. (1986) · Diabetologia · doi:10.1007/bf02427280 · Cited by 1,307 · see citing works
Ehrenkranz, J. R. L., Lewis, N., Kahn, C. R., & Roth, J. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.532 · Cited by 938 · see citing works
Vilsbøll, T., Krarup, T., Deacon, C. F., Madsbad, S., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.609 · Cited by 876 · see citing works
Stoffers, D. A., Kieffer, T. J., Hussain, M. A., Drucker, D. J., Bonner‐Weir, S., Habener, J. F., & Egan, J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.741 · Cited by 576 · see citing works
Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia
Xu, G., Kaneto, H., Laybutt, D. R., Duvivier-Kali, V. F., Trivedi, N., Suzuma, K., King, G. L., Weir, G. C., & Bonner‐Weir, S. (2007) · Diabetes · doi:10.2337/db06-1033 · Cited by 379 · see citing works
Fehmann, H. C., & Habener, J. F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309325 · Cited by 337 · see citing works
Elahi, D., McAloon-Dyke, M., Fukagawa, N. K., Meneilly, G. S., Sclater, A. L., Minaker, K. L., Habener, J. F., & Andersen, D. K. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90136-8 · Cited by 308 · see citing works
Kim, S., Winter, K. D., Nian, C., Tsuneoka, M., Koda, Y., & McIntosh, C. H. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500540200 · Cited by 241 · see citing works
Self-citationTrümper, A., Trümper, K., Trusheim, H., Arnold, R., Göke, B., & Hörsch, D. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0688 · Cited by 238 · see citing works
Pospisilik, J. A., Stafford, S. G., Demuth, H.-U., Brownsey, R. W., Parkhouse, W. S., Finegood, D. T., McIntosh, C. H. S., & Pederson, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.4.943 · Cited by 232 · see citing works
Self-citationVilsbøll, T., Knop, F. K., Krarup, T., Johansen, A., Madsbad, S., Larsen, S., Hansen, T. W., Pedersen, O. B., & Holst, J. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030738 · Cited by 230 · see citing works
The Insulinotropic Action of Gastric Inhibitory Polypeptide in the Perfused Isolated Rat Pancreas
Pederson, R. A., & Brown, J. C. (1976) · Endocrinology · doi:10.1210/endo-99-3-780 · Cited by 210 · see citing works
Self-citationLynn, F. C., Pamir, N., Ng, E. H. C., McIntosh, C. H. S., Kieffer, T. J., & Pederson, R. A. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1004 · Cited by 208 · see citing works
Self-citationGenetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia
Laybutt, D. R., Sharma, A., Sgroi, D. C., Gaudet, J., Bonner‐Weir, S., & Weir, G. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111751200 · Cited by 202 · see citing works
Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells
Zhou, Y.-T., Shimabukuro, M., Wang, M.-Y., Lee, Y., Higa, M., Milburn, J. L., Newgard, C. B., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8898 · Cited by 173 · see citing works
Ehses, J. A., Casilla, V. R., Doty, T., Pospisilik, J. A., Winter, K. D., Demuth, H., Pederson, R. A., & McIntosh, C. H. S. (2003) · Endocrinology · doi:10.1210/en.2002-0068 · Cited by 159 · see citing works
Self-citationRoduit, R., Morin, J., Massé, F., Segall, L., Roche, E., Newgard, C. B., Assimacopoulos‐Jeannet, F., & Prentki, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006001200 · Cited by 158 · see citing works
Harmon, J. S., Gleason, C. E., Tanaka, Y., Poitout, V., & Robertson, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2481 · Cited by 140 · see citing works
Pospisilik, J. A., Stafford, S. G., Demuth, H., McIntosh, C. H. S., & Pederson, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2677 · Cited by 138 · see citing works
Self-citationLalloyer, F., Vandewalle, B., Percevault, F., Torpier, G., Kerr-Conte, J. A., Oosterveer, M. H., Paumelle, R., Fruchart, J., Kuipers, F., Pattou, F. N., et al. (2006) · Diabetes · doi:10.2337/db06-0016 · Cited by 115 · see citing works
The pathogenesis of NIDDM involves a defective expression of the GIP receptor
Holst, J. J., Gromada, J., & Nauck, M. A. (1997) · Diabetologia · doi:10.1007/s001250050779 · Cited by 111 · see citing works
Lynn, F. C., Thompson, S. A., Pospisilik, J. A., Ehses, J. A., Hinke, S. A., Pamir, N., McIntosh, C. H. S., & Pederson, R. A. (2003) · The FASEB Journal · doi:10.1096/fj.02-0243fje · Cited by 91 · see citing works
Self-citationRecent Developments in Inhibiting Cysteine and Serine Proteases
Demuth, H. (1990) · Journal of enzyme inhibition · doi:10.3109/14756369009030375 · Cited by 87 · see citing works
Self-citationAlmind, K., Ambye, L., Urhammer, S. A., Hansen, T. F., Echwald, S. M., Holst, J. J., Gromada, J., Thorens, B., & Pedersen, O. B. (1998) · Diabetologia · doi:10.1007/s001250051051 · Cited by 68 · see citing works
Kubota, A., Yamada, Y., HAYAMI, T., Yasuda, K., Someya, Y., Ihara, Y., Kagimoto, S., Watanabe, R., Taminato, T., Tsuda, K., et al. (1996) · Diabetes · doi:10.2337/diab.45.12.1701 · Cited by 62 · see citing works
Tseng, C., Boylan, M. O., Jarboe, L. A., Usdin, T. B., & Wolfe, M. M. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e661 · Cited by 56 · see citing works
Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus
McIntosh, C. H. S., Demuth, H., Kim, S.-J., Pospisilik, J. A., & Pederson, R. A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.12.013 · Cited by 54 · see citing works
Self-citationCharacterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription
Fehmann, H. C., & Göke, B. (1995) · Peptides · doi:10.1016/0196-9781(95)00090-7 · Cited by 50 · see citing works
Hinke, S., Pauly, R., Ehses, J. A., Kerridge, P., Demuth, H.-U., McIntosh, C. H. S., & Pederson, R. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650281 · Cited by 24 · see citing works
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Flagged first, then by citations
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Sorted by citations
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824 · see citing works
GIP and GLP-1, the two incretin hormones: Similarities and differences
Seino, Y., Fukushima, M., & Yabe, D. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00022.x · Cited by 746 · see citing works
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683 · see citing works
Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs
Artasensi, A., Pedretti, A., Vistoli, G., & Fumagalli, L. (2020) · Molecules · doi:10.3390/molecules25081987 · Cited by 502 · see citing works
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
Åhrén, B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2782 · Cited by 417 · see citing works
Højberg, P. V., Vilsbøll, T., Rabøl, R., Knop, F. K., Bache, M., Krarup, T., Holst, J. J., & Madsbad, S. (2009) · Diabetologia · doi:10.1007/s00125-008-1195-5 · Cited by 414 · see citing works
Nauck, M. A., Quast, D. R., Wefers, J., & Pfeiffer, A. F. H. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14496 · Cited by 388 · see citing works
Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes
Holst, J. J., Knop, F. K., Vilsbøll, T., Krarup, T., & Madsbad, S. (2011) · Diabetes Care · doi:10.2337/dc11-s227 · Cited by 280 · see citing works
Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
Drucker, D. J. (2013) · Diabetes · doi:10.2337/db13-0822 · Cited by 272 · see citing works
Shu, L., Matveyenko, A. V., Kerr-Conte, J. A., Cho, J., McIntosh, C. H. S., & Maedler, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp178 · Cited by 269 · see citing works
Self-citationThe effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones
Meek, C. L., Lewis, H. B., Reimann, F. M., Gribble, F. M., & Park, A. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.08.013 · Cited by 268 · see citing works
Oeseburg, H., de Boer, R. A., Buikema, H., van der Harst, P., van Gilst, W. H., & Silljé, H. H. W. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.206425 · Cited by 267 · see citing works
The incretin system in healthy humans: The role of GIP and GLP-1
Holst, J. J. (2019) · Metabolism · doi:10.1016/j.metabol.2019.04.014 · Cited by 248 · see citing works
GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists
Holst, J. J., & Rosenkilde, M. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa327 · Cited by 207 · see citing works
Yabe, D., & Seino, Y. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.07.010 · Cited by 189 · see citing works
Chapter 15 Glucose‐Dependent Insulinotropic Polypeptide (Gastric Inhibitory Polypeptide; GIP)
McIntosh, C. H. S., Widenmaier, S. B., & Kim, S. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(08)00615-8 · Cited by 172 · see citing works
Self-citationPotential Hormone Mechanisms of Bariatric Surgery
Dimitriadis, G. K., Randeva, M. S., & Miras, A. D. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0276-5 · Cited by 168 · see citing works
Glucagon-like peptide-1, glucose homeostasis and diabetes
Holst, J. J., Deacon, C. F., Vilsbøll, T., Krarup, T., & Madsbad, S. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.01.003 · Cited by 160 · see citing works
New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics
Jastreboff, A. M., & Kushner, R. F. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-043021-014919 · Cited by 158 · see citing works
GPR119 agonists for the treatment of type 2 diabetes
Jones, R. M., Leonard, J. N., Buzard, D. J., & Lehmann, J. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903153878 · Cited by 154 · see citing works
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
Capozzi, M. E., DiMarchi, R. D., Tschöp, M. H., Finan, B., & Campbell, J. E. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00117 · Cited by 153 · see citing works
The role of glucagon‐like peptide‐1 impairment in obesity and potential therapeutic implications
Madsbad, S. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12119 · Cited by 146 · see citing works
The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
Bany Bakar, R., Reimann, F., & Gribble, F. M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00830-y · Cited by 144 · see citing works
Targeting the glucagon receptor family for diabetes and obesity therapy
Cho, Y. M., Merchant, C. E., & Kieffer, T. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.05.009 · Cited by 142 · see citing works
Lorenz, M., Evers, A., & Wagner, M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.05.022 · Cited by 126 · see citing works
Incretins: their physiology and application in the treatment of diabetes mellitus
Tasyurek, H. M., Altunbas, H. A., Balci, M. K., & Sanlioglu, S. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2501 · Cited by 121 · see citing works
Hansen, K. B., Vilsbøll, T., Bagger, J. I., Holst, J. J., & Knop, F. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0119 · Cited by 109 · see citing works
Åhrén, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.03.003 · Cited by 108 · see citing works
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Oduori, O. S., Murao, N., Shimomura, K., Takahashi, H., Zhang, Q., Dou, H.-Q., Sakai, S., Minami, K., Chanclón, B., Guida, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140046 · Cited by 85 · see citing works
Therapeutic potential for GIP receptor agonists and antagonists
Irwin, N., & Flatt, P. R. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.03.001 · Cited by 105 · see citing works
Widenmaier, S. B., Kim, S. J., Yang, G. K., Reyes, T. D. L., Nian, C., Asadi, A., Seino, Y., Kieffer, T. J., Kwok, Y. N., & McIntosh, C. H. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009590 · Cited by 102 · see citing works
Self-citationPicatoste, B., Ramírez, E., Caro‐Vadillo, A., Iborra, C., Egido, J., Tuñón, J., & Lorenzo, Ó. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078330 · Cited by 101 · see citing works
The role of GIP in α-cells and glucagon secretion
EL, K. M., & Campbell, J. E. (2019) · Peptides · doi:10.1016/j.peptides.2019.170213 · Cited by 97 · see citing works
Control of insulin secretion by GLP-1
Jones, B. J., Bloom, S. R., Buenaventura, T., Tomás, A., & Rutter, G. A. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.013 · Cited by 96 · see citing works
Killion, E. A., Lu, S.-C., Fort, M., Yamada, Y., Véniant, M. M., & Lloyd, D. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz002 · Cited by 94 · see citing works
Incretins in obesity and diabetes
Chia, C. W., & Egan, J. M. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14211 · Cited by 93 · see citing works
Glucose-dependent insulinotropic polypeptide (GIP)
Müller, T. D., Adriaenssens, A. E., Ahrén, B., Blüher, M., Birkenfeld, A. L., Campbell, J. E., Coghlan, M. P., D’Alessio, D. D., Deacon, C. F., DelPrato, S., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102118 · Cited by 99 · see citing works
K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease
Cho, Y. M., & Kieffer, T. J. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00004-7 · Cited by 93 · see citing works
Rao, R. S., & Kini, S. U. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0305-x · Cited by 93 · see citing works
Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
Gasbjerg, L. S., Gabe, M. B. N., Hartmann, B., Christensen, M. B., Knop, F. K., Holst, J. J., & Rosenkilde, M. M. (2018) · Peptides · doi:10.1016/j.peptides.2017.11.021 · Cited by 85 · see citing works
Dipeptidyl Peptidase-4 at the Interface Between Inflammation and Metabolism
Trzaskalski, N. A., Fadzeyeva, E., & Mulvihill, E. E. (2020) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.1177/1179551420912972 · Cited by 85 · see citing works
Meirelles, K., Ahmed, T., Culnan, D. M., Lynch, C. J., Lang, C. H., & Cooney, R. N. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181904af0 · Cited by 81 · see citing works
Zaïmia, N., Obeid, J., Varrault, A., Sabatier, J., Broca, C., Gilon, P., Costes, S., Bertrand, G., & Ravier, M. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113326 · Cited by 78 · see citing works
Obesity and Type 2 Diabetes: Adiposopathy as a Triggering Factor and Therapeutic Options
Artasensi, A., Mazzolari, A., Pedretti, A., Vistoli, G., & Fumagalli, L. (2023) · Molecules · doi:10.3390/molecules28073094 · Cited by 65 · see citing works
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances
Asmar, M., & Holst, J. J. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283339051 · Cited by 59 · see citing works
Kang, Z., Deng, Y., Zhou, Y., Fan, R., Chan, J. C. N., Laybutt, D. R., Luzuriaga, J., & Xu, G. (2012) · Diabetologia · doi:10.1007/s00125-012-2776-x · Cited by 54 · see citing works
Holst, J. J., Albrechtsen, N. J. W., ROSENKILDE, M. M., & Deacon, C. F. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180013 · Cited by 71 · see citing works
Martin, C. M. A., Irwin, N., Flatt, P. R., & Gault, V. A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.011 · Cited by 53 · see citing works
Irwin, N., Gault, V. A., & Flatt, P. R. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.513381 · Cited by 53 · see citing works
GIP analogues and the treatment of obesity-diabetes
Bailey, C. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.170202 · Cited by 51 · see citing works
GIP Contributes to Islet Trihormonal Abnormalities in Type 2 Diabetes
Chia, C. W., Odetunde, J. O., Kim, W., Carlson, O. D., Ferrucci, L., & Egan, J. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3994 · Cited by 51 · see citing works
Aaboe, K., Akram, S., Deacon, C. F., Holst, J. J., Madsbad, S., & Krarup, T. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12395 · Cited by 49 · see citing works
Gupta, D., Peshavaria, M., Monga, N., Jetton, T. L., & Leahy, J. L. (2010) · Diabetes · doi:10.2337/db09-1655 · Cited by 47 · see citing works
Kerr, B. D., Irwin, N., O'Harte, F. P. M., Bailey, C. J., Flatt, P. R., & Gault, V. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.037 · Cited by 44 · see citing works
Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential
Pathak, N. M., Pathak, V., Gault, V. A., McClean, S., Irwin, N., & Flatt, P. R. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.021 · Cited by 43 · see citing works
Jeon, E., Lee, K. Y., & Kim, K.-K. (2023) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes23032 · Cited by 39 · see citing works
Gault, V. A., Martin, C. M., Flatt, P. R., Parthsarathy, V., & Irwin, N. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0681-0 · Cited by 39 · see citing works
Irwin, N., Hunter, K., Frizzell, N., & Flatt, P. R. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.11.007 · Cited by 38 · see citing works
Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity
Opinto, G., Natalicchio, A., & Marchetti, P. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.812664 · Cited by 38 · see citing works
Gabe, M. B. N., van der Velden, W. J. C., Smit, F. X., Gasbjerg, L. S., & ROSENKILDE, M. M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170224 · Cited by 37 · see citing works
Gault, V. A., Kerr, B. D., Irwin, N., & Flatt, P. R. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.03.011 · Cited by 36 · see citing works
Ahn, C. H., Oh, T. J., Kwak, S. H., & Cho, Y. M. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13081 · Cited by 33 · see citing works
DPP-4 Inhibitors Improve Liver Dysfunction in Type 2 Diabetes Mellitus
Sugimoto, T. (2014) · Medical Science Monitor · doi:10.12659/msm.890989 · Cited by 33 · see citing works
Hasib, A., Ng, M. T., Gault, V. A., Khan, D., Parthsarathy, V., Flatt, P. R., & Irwin, N. (2016) · Diabetologia · doi:10.1007/s00125-016-4186-y · Cited by 33 · see citing works
Recent advances of GIP and future horizons
Holst, J. J., & ROSENKILDE, M. M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170230 · Cited by 33 · see citing works
Tatarkiewicz, K., Hargrove, D. M., Jodka, C. M., Gedulin, B. R., Smith, P. A., Hoyt, J. A., Lwin, A. N., Collins, L., Мамедова, Л. Т., Levy, O. E., et al. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12181 · Cited by 32 · see citing works
Martin, C. M., Parthsarathy, V., Hasib, A., Ng, M. T., McClean, S., Flatt, P. R., Gault, V. A., & Irwin, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152818 · Cited by 32 · see citing works
Ismail, S., Dubois-Vedrenne, I., Laval, M., Tikhonova, I. G., D’Angelo, R., Sanchez, C., Clerc, P., Ghérardi, M.-J., Gigoux, V., Magnan, R., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.001 · Cited by 31 · see citing works
Renner, S., Blutke, A., Streckel, E., Wanke, R., & Wolf, E. (2015) · The Journal of Pathology · doi:10.1002/path.4655 · Cited by 31 · see citing works
Aging-related modifications to G protein-coupled receptor signaling diversity
van Gastel, J., Leysen, H., Boddaert, J., Vangenechten, L., Luttrell, L. M., Martin, B., & Maudsley, S. R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107793 · Cited by 31 · see citing works
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
Adriaenssens, A. E., Reimann, F. M., & Gribble, F. M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170047 · Cited by 35 · see citing works
Hasib, A. (2020) · Clinical Medicine Insights: Endocrinology and Diabetes · doi:10.1177/1179551420905844 · Cited by 29 · see citing works
Guccio, N., Gribble, F. M., & Reimann, F. M. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-113625 · Cited by 29 · see citing works
Yanagimachi, T., Fujita, Y., Takeda, Y., Honjo, J., Atageldiyeva, K. K., Takiyama, Y., Abiko, A., Makino, Y., Kieffer, T. J., & Haneda, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3842-y · Cited by 27 · see citing works
The emerging role of the intestine in metabolic diseases
Bradley, W. D., Zwingelstein, C., & Rondinone, C. M. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2011.578651 · Cited by 24 · see citing works
Nyirjesy, S. C., Peleckis, A. J., Eiel, J. N., Gallagher, K., Doliba, A., Tami, A., Flatt, A. J., León, D. D. D., Hadjiliadis, D., Sheikh, S., et al. (2022) · Diabetes · doi:10.2337/db22-0399 · Cited by 24 · see citing works
Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels
Góralska, J., Raźny, U., Polus, A., Stancel-Możwiłło, J., Chojnacka, M., Gruca, A., Zdzienicka, A., Dembińska-Kieć, A., Kieć-Wilk, B., Solnica, B., et al. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.305 · Cited by 22 · see citing works
The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
Hutch, C. R., Roelofs, K. J., Haller, A. M., Sorrell, J. E., Leix, K., D’Alessio, D. D., Augustin, R., Seeley, R. J., Klein, T., & Sandoval, D. A. (2019) · Diabetologia · doi:10.1007/s00125-019-4963-5 · Cited by 22 · see citing works
Postpartum reversibility of impaired incretin effect in gestational diabetes mellitus
Kosiński, M., Knop, F. K., Vedtofte, L., Grycewiczv, J., Swierzewska, P., Cypryk, K., & Vilsbøll, T. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.08.002 · Cited by 22 · see citing works
Millar, P., Pathak, V., Moffett, R. C., Pathak, N., Bjourson, A. J., O’Kane, M., Flatt, P. R., & Gault, V. A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.11.019 · Cited by 22 · see citing works
Sharma, A., Paliwal, G., Upadhyay, N., & Tiwari, A. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0143-4 · Cited by 22 · see citing works
RetractedHolst, J. J., Albrechtsen, N. J. W., ROSENKILDE, M. M., & Deacon, C. F. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00092.x · Cited by 19 · see citing works
Gigoux, V., & Fourmy, D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00050 · Cited by 19 · see citing works
Meal test for glucose-dependent insulinotropic peptide (GIP) in obese and type 2 diabetic patients
Škrha, J., Hilgertová, J., Jarolimkova, M., Kunešová, M., & Hill, M. (2010) · Physiological Research · doi:10.33549/physiolres.931893 · Cited by 19 · see citing works
Pathak, V., Vasu, S., Flatt, P. R., & Irwin, N. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12227 · Cited by 17 · see citing works
Fushimi, Y., Obata, A., Sanada, J., Nogami, Y., Ikeda, T., Yamasaki, Y., Obata, Y., Shimoda, M., Nakanishi, S., Mune, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94896-w · Cited by 17 · see citing works
Antibodies in metabolic diseases
Ahrens, B. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.03.022 · Cited by 17 · see citing works
Prévost, G., Arabo, A., Solliec, M.-A. L., Bons, J., Picot, M., Maucotel, J., Berrahmoune, H., Mehdi, M. E., Cherifi, S., Bénani, A., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00540.2018 · Cited by 16 · see citing works
Lewandowski, S. L., EL, K. M., & Campbell, J. E. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00360.2023 · Cited by 14 · see citing works
GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes
Ciardullo, S., Morieri, M. L., DANIELE, G., Fiorentino, T. V., Mezza, T., Tricò, D., Consoli, A., Prato, S. D., Giorgino, F., Piro, S., et al. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02300-6 · Cited by 15 · see citing works
Flis, M., Rodziewicz-Flis, E. A., Micielska, K., Kortas, J. A., Jaworska, J., Borkowska, A., Sansoni, V., Perego, S., Lombardi, G., & Ziemann, E. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5015 · Cited by 13 · see citing works
Gao, Z., Yang, J., Liang, Y., Yang, S., Zhang, T., Gong, Z., & Li, M. (2022) · Obesity Surgery · doi:10.1007/s11695-022-05959-4 · Cited by 12 · see citing works
Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice
McShane, L. M., Irwin, N., O’Flynn, D., Franklin, Z. J., Hewage, C. M., & O'Harte, F. P. M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0463 · Cited by 12 · see citing works
β‐Cell biology of insulin secretion
Seino, D. M. S. S., Shibasaki, T., & Minami, K. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch7 · Cited by 16 · see citing works
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
Adriaenssens, A. E., Reimann, F. M., & Gribble, F. M. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00048.x · Cited by 9 · see citing works
Gut Peptide Agonism in the Treatment of Obesity and Diabetes
Grandl, G., Novikoff, A., DiMarchi, R. D., Tschöp, M. H., & Müller, T. D. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180044 · Cited by 9 · see citing works
Picatoste, B., RamÃrez, E., Caro‐Vadillo, A., Iborra, C., Egido, J., n, J. T., & Lorenzo, Ó. (2013) · PLoS ONE · doi:10.1371/annotation/df98874f-c1bd-4a13-b474-942fbb956287 · Cited by 9 · see citing works
Polyagonists in Type 2 Diabetes Management
Dissanayake, H. A., & Somasundaram, N. P. (2024) · Current Diabetes Reports · doi:10.1007/s11892-023-01530-2 · Cited by 8 · see citing works
Incretin and Pancreatic β-Cell Function in Patients with Type 2 Diabetes
Ahn, C. H., Oh, T. J., Min, S. H., & Cho, Y. M. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.103 · Cited by 8 · see citing works
- Authors
- Piteau, S., Olver, A., Kim, S.-J., Winter, K., Pospisilik, J. A., Lynn, F., Manhart, S., Demuth, H.-U., Speck, M., Pederson, R. A., & McIntosh, C. H. S.
- Affiliations
- University of British Columbia (CA)
- Institute of Molecular Biotechnology (AT)
- University of California, San Francisco (US)
- Probiodrug (Germany) (DE)
- Corresponding author
- McIntosh, Christopher H.S.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 362
- Issue
- 4
- Pages
- 1007-1012
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1964575982
- Cited by
- 130
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 12 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 12 · 2012: 2
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Diabetes Association
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- glucose-dependent insulinotropic polypeptide, GIP receptor, receptor down-regulation, type 2 diabetes, hyperglycemia, pancreatic islets, phloridzin, DPP-4 inhibitors, glucose tolerance, Zucker rats, glycemic control
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Drug Resistance, Gastric Inhibitory Polypeptide, Hyperglycemia, Insulin Resistance, Rats, Zucker, Receptors, Gastrointestinal Hormone, Down-Regulation, Treatment Outcome, Rats
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