Cited by 146Diabetes Treatment and ManagementRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

The role of glucagon‐like peptide‐1 impairment in obesity and potential therapeutic implications

Madsbad, S.·2014·Diabetes, Obesity and Metabolism

Abstract

The hormone glucagon‐like peptide‐1 ( GLP ‐1) is released from the gut in response to food intake. It acts as a satiety signal, leading to reduced food intake, and also as a regulator of gastric emptying. Furthermore, GLP ‐1 functions as an incretin hormone, stimulating insulin release and inhibiting glucagon secretion from the pancreas in response to food ingestion. Evidence suggests that the action or effect of GLP ‐1 may be impaired in obese subjects, even in those with normal glucose tolerance. GLP ‐1 impairment may help explain the increased gastric emptying and decreased satiety signalling seen in obesity. Incretin impairment, probably associated with reduced insulinotropic potency of GLP ‐1, is also characteristic of type 2 diabetes (T2D). Therefore, it is possible that incretin impairment may contribute to the pathophysiological bridge between obesity and T2D. This review summarises current knowledge about the pathophysiology and consequences of GLP ‐1 and incretin impairment in obesity, and examines the evidence for an incretin‐related link between obesity and T2D. It also considers the current literature surrounding the novel use of GLP ‐1 receptor agonists as a treatment for obesity in patients with normoglycaemia, prediabetes and T2D.

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Crossref · 10.1111/dom.12119

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155 of 155 references verified0 citation errors · 0 not checkable

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  • Postprandial GLP‐1 secretion is increased in obese patients following bariatric surgery and correlates with weight loss maintenance.

    “Interestingly, postprandial glucagon‐like peptide‐1 (GLP‐1) secretion is increased in obese patients following bariatric surgery and correlates with weight loss maintenance 139.”
  • A reduced incretin effect is seen in subjects with type 2 diabetes (T2D) and obesity.

    “Moreover, a reduced incretin effect is seen in subjects with type 2 diabetes (T2D) and obesity.”

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Authors
Madsbad, S.
Affiliations
Hvidovre Hospital (DK)
Corresponding author
Madsbad, S.
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2013-05-26
Volume
16
Issue
1
Pages
9-21
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
OpenAlex
W1988527243
Cited by
146
References
155
Citations by year
2026: 2 · 2025: 10 · 2024: 6 · 2023: 12 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 20 · 2013: 3 · 2012: 1
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Novo Nordisk
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
glucagon-like peptide-1, GLP-1 receptor agonists, obesity, type 2 diabetes, gastric emptying, insulin secretion, glucagon secretion, prediabetes, obesity treatment
MeSH terms
Glucagon-Like Peptide-1 Receptor, Insulin Secretion, Blood Glucose, Diabetes Mellitus, Type 2, Gastric Emptying, Gastrointestinal Motility, Humans, Insulin, Obesity, Satiation, Receptors, Glucagon, Glucagon-Like Peptide 1, Incretins

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