Incretins in obesity and diabetes
Open accessAbstract
Incretins are hormones secreted from enteroendocrine cells after nutrient intake that stimulate insulin secretion from β cells in a glucose‐dependent manner. Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the only two known incretins. Dysregulation of incretin secretion and actions are noted in diseases such as obesity and diabetes. In this review, we first summarize our traditional understanding of the physiology of GIP and GLP‐1, and our current knowledge of the relationships between GIP and GLP‐1 and obesity and diabetes. Next, we present the results from major randomized controlled trials on the use of GLP‐1 receptor agonists for managing type 2 diabetes, and emerging data on treating obesity and prediabetes. We conclude with a glimpse of the future with possible complex interactions between nutrients, gut microbiota, the endocannabinoid system, and enteroendocrine cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Because of their impact on weight reduction, incretins may find increasing use in diabesity.
“Because of the impact on weight reduction, incretins may find increasing use in diabesity, which is the coexistence of diabetes and obesity (193).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [193]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629 · see citing works
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607141 · Cited by 6,900 · see citing works
Bariatric Surgery: A Systematic Review and Meta-analysis
Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) · JAMA · doi:10.1001/jama.292.14.1724 · Cited by 6,800 · see citing works
Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,970 · see citing works
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works
Davies, M. J., D’Alessio, D. A., Fradkin, J., Kernan, W. N., Mathieu, C., Mingrone, G., Rossing, P., Tsapas, A., Wexler, D. J., & Buse, J. B. (2018) · Diabetes Care · doi:10.2337/dci18-0033 · Cited by 3,518 · see citing works
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works
Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2015) · Diabetes Care · doi:10.2337/dc14-2441 · Cited by 3,066 · see citing works
Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041 · see citing works
Formation of propionate and butyrate by the human colonic microbiota
Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028 · see citing works
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., Lau, D. C. W., le Roux, C. W., Violante Ortiz, R., Jensen, C. B., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411892 · Cited by 2,724 · see citing works
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome
Pfeffer, M. A., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H. C., Køber, L. V., Lawson, F. C., Ping, L., Wei, X., Lewis, E. F., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1509225 · Cited by 2,409 · see citing works
Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293 · see citing works
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Drucker, D. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.001 · Cited by 2,170 · see citing works
Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
Holman, R. R., Bethel, M. A., Mentz, R. J., Thompson, V. P., Lokhnygina, Y., Buse, J. B., Chan, J. C., Choi, J., Gustavson, S. M., Iqbal, N., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612917 · Cited by 2,162 · see citing works
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · see citing works
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Husain, M., Birkenfeld, A. L., Donsmark, M., Dungan, K., Eliaschewitz, F. G., Franco, D. R., Jeppesen, O. K., Lingvay, I., Mosenzon, O., Pedersen, S. D., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1901118 · Cited by 1,997 · see citing works
Glucagon-like peptide-1 7–36: a physiological incretin in man
Kreymann, B., Ghatei, M. A., Williams, G., & Bloom, S. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91194-9 · Cited by 1,928 · see citing works
Hernandez, A. F., Green, J. B., Janmohamed, S., D'Agostino, R. B., Granger, C. B., Jones, N. P., Leiter, L. A., Rosenberg, A. E., Sigmon, K. N., Somerville, M. C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32261-x · Cited by 1,829 · see citing works
Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651 · see citing works
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,535 · see citing works
Buse, J. B., Rosenstock, J., Sesti, G., Schmidt, W. E., Montanya, E., Brett, J. H., Zychma, M., & Blonde, L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60659-0 · Cited by 1,503 · see citing works
Pharmacology, physiology, and mechanisms of incretin hormone action.
Campbell, J. E., & Drucker, D. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.008 · Cited by 1,500 · see citing works
Signals from the gut microbiota to distant organs in physiology and disease
Schroeder, B. O., & Bäckhed, F. (2016) · Nature Medicine · doi:10.1038/nm.4185 · Cited by 1,409 · see citing works
Reduced incretin effect in Type 2 (non-insulin dependent) diabetes
Nauck, M., Stöckmann, F., Ebert, R., & Creutzfeldt, W. (1986) · Diabetologia · doi:10.1007/bf02427280 · Cited by 1,307 · see citing works
Zander, M., Madsbad, S., Madsen, J. L., & Holst, J. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07952-7 · Cited by 1,297 · see citing works
The mechanism of pancreatic secretion
Bayliss, W. M., & Starling, E. H. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000920 · Cited by 1,274 · see citing works
Kendall, D. M., Riddle, M. C., Rosenstock, J., Zhuang, D., Kim, D. D., Fineman, M. S., & Baron, A. D. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1083 · Cited by 1,177 · see citing works
Kieffer, T. J., McIntosh, C. H., & Pederson, R. A. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628397 · Cited by 1,124 · see citing works
Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
Lau, J., Bloch, P., Schäffer, L., Pettersson, I., Spetzler, J., Kofoed, J., Madsen, K., Knudsen, L. B., McGuire, J., Steensgaard, D. B., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00726 · Cited by 1,105 · see citing works
Nauck, M. A., Kleine, N., �rskov, C., Holst, J. J., Willms, B., & Creutzfeldt, W. (1993) · Diabetologia · doi:10.1007/bf00401145 · Cited by 1,092 · see citing works
Drucker, D. J., Buse, J. B., Taylor, K., Kendall, D. M., Trautmann, M., Zhuang, D., & Porter, L. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61206-4 · Cited by 1,070 · see citing works
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1× · see citing works
“peptide-1 (7-37) in normal and diabetic subjects.”
Self-citationVilsboll, T., Christensen, M., Junker, A. E., Knop, F. K., & Gluud, L. L. (2012) · BMJ · doi:10.1136/bmj.d7771 · Cited by 970 · see citing works
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963 · see citing works
Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
Elashoff, M., Matveyenko, A. V., Gier, B., Elashoff, R., & Butler, P. C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.018 · Cited by 944 · see citing works
Mojsov, S., Weir, G. C., & Habener, J. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112855 · Cited by 882 · see citing works
Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works
Coskun, T., Sloop, K. W., Loghin, C., Alsina-Fernandez, J., Urva, S., Bokvist, K. B., Cui, X., Briere, D. A., Cabrera, O., Roell, W. C., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.09.009 · Cited by 882 · see citing works
Vilsbøll, T., Krarup, T., Deacon, C. F., Madsbad, S., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.609 · Cited by 876 · see citing works
NAUCK, M. A., HOMBERGER, E., SIEGEL, E. G., ALLEN, R. C., EATON, R. P., EBERT, R., & CREUTZFELDT, W. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-492 · Cited by 874 · see citing works
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
Toft-Nielsen, M.-B., Damholt, M. B., Madsbad, S., Hilsted, L. M., Hughes, T. E., Michelsen, B. K., & Holst, J. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7750 · Cited by 869 · see citing works
STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN. <sup>1</sup>
Dupre, J., Ross, S. A., Watson, D., & Brown, J. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-826 · Cited by 860 · see citing works
Plasma Insulin Response to Oral and Intravenous Glucose Administration1
ELRICK, H., STIMMLER, L., HLAD, C. J., & ARAI, Y. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-10-1076 · Cited by 857 · see citing works
le Roux, C. W., Astrup, A., Fujioka, K., Greenway, F., Lau, D. C. W., Van Gaal, L., Ortiz, R. V., Wilding, J. P. H., Skjøth, T. V., Manning, L. S., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30069-7 · Cited by 850 · see citing works
on behalf of the NN8022-1923 Investigators, Wadden, T. A., Hollander, P., Klein, S., Niswender, K., Woo, V, Hale, P. M., & Aronne, L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.120 · Cited by 842 · see citing works
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824 · see citing works
Self-citationNauck, M. A., Niedereichholz, U., Ettler, R., Holst, J. J., Ørskov, C., Ritzel, R. A., & Schmiegel, W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e981 · Cited by 822 · see citing works
Frias, J. P., Nauck, M. A., Van, J., Kutner, M. E., Cui, X., Benson, C., Urva, S., Gimeno, R. E., Milicevic, Z., Robins, D., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32260-8 · Cited by 815 · see citing works
O'Neil, P. M., Birkenfeld, A. L., McGowan, B., Mosenzon, O., Pedersen, S. D., Wharton, S., Carson, C. G., Jepsen, C. H., Kabisch, M., & Wilding, J. P. H. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31773-2 · Cited by 814 · see citing works
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793 · see citing works
Scrocchi, L. A., Brown, T. J., Maclusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., & Drucker, D. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1254 · Cited by 793 · see citing works
Pratley, R. E., Aroda, V. R., Lingvay, I., Lüdemann, J., Andreassen, C., Navarria, A., & Viljoen, A. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30024-x · Cited by 790 · see citing works
New Interpretation of Oral Glucose Tolerance
Mcintyre, N., Holdsworth, C. D., & Turner, D. S. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90011-x · Cited by 738 · see citing works
Creutzfeldt, W. (1979) · Diabetologia · doi:10.1007/bf01225454 · Cited by 731 · see citing works
Knudsen, L. B., Nielsen, P. F., Huusfeldt, P. O., Johansen, N. L., Madsen, K., Pedersen, F. Z., Thøgersen, H., Wilken, M., & Agersø, H. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm9909645 · Cited by 705 · see citing works
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
Finan, B., Ma, T., Ottaway, N., Müller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007218 · Cited by 696 · see citing works
Elliott, R. M., Morgan, L. M., Tredger, J. A., Deacon, S., Wright, J., & Marks, V. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1380159 · Cited by 695 · see citing works
Mechanisms of action of glucagon-like peptide 1 in the pancreas
Doyle, M. E., & Egan, J. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.007 · Cited by 679 · see citing works
Self-citationTruncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man
Wettergren, A., Schjoldager, B., Mortensen, P. E., Myhre, J., Christiansen, J., & Holst, J. J. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01316798 · Cited by 670 · see citing works
Overton, H. A., Babbs, A. J., Doel, S. M., Fyfe, M. C. T., Gardner, L. S., Griffin, G., Jackson, H. C., Procter, M. J., Rasamison, C. M., Tang‐Christensen, M., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.004 · Cited by 656 · see citing works
Rubino, F., Gagner, M., Gentileschi, P., Kini, S. U., Fukuyama, S., Feng, J. J., & Diamond, E. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133117.12646.48 · Cited by 638 · see citing works
Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut
Holst, J. J., Ørskov, C., Nielsen, O. V., & Schwartz, T. W. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81430-8 · Cited by 611 · see citing works
Nauck, M. A., Heimesaat, M. M., Behle, K., Holst, J. J., Nauck, M. S., Ritzel, R., Hüfner, M., & Schmiegel, W. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8355 · Cited by 605 · see citing works
Verdich, C., Flint, A., Gutzwiller, J., Näslund, E. B., Beglinger, C., Hellström, P. M., Long, S. J., Morgan, L., Holst, J. J., & Astrup, A. V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7877 · Cited by 600 · see citing works
Ahmann, A. J., Capehorn, M., Charpentier, G., Dotta, F., Henkel, E., Lingvay, I., Holst, A. G., Annett, M. P., & Aroda, V. R. (2018) · Diabetes Care · doi:10.2337/dc17-0417 · Cited by 596 · see citing works
Hansen, L., Deacon, C. F., Ørskov, C., & Holst, J. J. (1999) · Endocrinology · doi:10.1210/endo.140.11.7143 · Cited by 595 · see citing works
on behalf of the SCALE study group, Blackman, A., Foster, G. D., Zammit, G., Rosenberg, R., Aronne, L., Wadden, T., Claudius, B., Jensen, C. B., & Mignot, E. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.52 · Cited by 583 · see citing works
The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion
Kjems, L. L., Holst, J. J., Vølund, A., & Madsbad, S. (2003) · Diabetes · doi:10.2337/diabetes.52.2.380 · Cited by 582 · see citing works
Nauck, M. A., Meier, J. J., Cavender, M. A., Abd El Aziz, M., & Drucker, D. J. (2017) · Circulation · doi:10.1161/circulationaha.117.028136 · Cited by 582 · see citing works
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578 · see citing works
Buse, J. B., Nauck, M., Forst, T., Sheu, W. H.-H., Shenouda, S. K., Heilmann, C. R., Hoogwerf, B. J., Gao, A., Boardman, M. K., Fineman, M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61267-7 · Cited by 565 · see citing works
Kolterman, O., Buse, J. B., Fineman, M. S., Gaines, E., Heintz, S., Bicsak, T. A., Taylor, K., Kim, D. S., Aisporna, M., Wang, Y., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021545 · Cited by 549 · see citing works
Glucagon-like peptide 1 in health and disease
Andersen, A., Lund, A., Knop, F. K., & Vilsbøll, T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0016-2 · Cited by 543 · see citing works
Brubaker, P. L., & Drucker, D. J. (2004) · Endocrinology · doi:10.1210/en.2004-0015 · Cited by 539 · see citing works
Laferrère, B., Heshka, S., Wang, K., Khan, Y., McGinty, J., Teixeira, J., Hart, A. B., & Olivan, B. (2007) · Diabetes Care · doi:10.2337/dc06-1549 · Cited by 532 · see citing works
Vilsbøll, T., Krarup, T., Sonne, J., Madsbad, S., Vølund, A., Juul, A. G., & Holst, J. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021873 · Cited by 528 · see citing works
Management of Hyperglycemia in Type 2 Diabetes
SKOLNIK, N., & OLSON, C. (2012) · Family Practice News · doi:10.1016/s0300-7073(12)70593-5 · Cited by 521 · see citing works
T., V., T., K., S., M., & J., H. (2002) · Diabetologia · doi:10.1007/s00125-002-0878-6 · Cited by 518 · see citing works
Agersø, H., Jensen, L. B., Elbrønd, B., Rolan, P., & Zdravkovic, M. (2002) · Diabetologia · doi:10.1007/s00125-001-0719-z · Cited by 510 · see citing works
Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins
Dennis, M. S., Zhang, M., Meng, Y., Kadkhodayan, M., Kirchhofer, D., Combs, D., & Damico, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205854200 · Cited by 508 · see citing works
Nauck, M. A., Bartels, E., Ørskov, C., Ebert, R., & Creutzfeldt, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473405 · Cited by 505 · see citing works
Pancreatic safety of incretin-based drugs–FDA and EMA assessment
Egan, A. G., Blind, E., Dunder, K., de Graeff, P. A., Hummer, B. T., Bourcier, T., & Rosebraugh, C. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1314078 · Cited by 498 · see citing works
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498 · see citing works
Dungan, K. M., Povedano, S. T., Forst, T., González, J. G. G., Atisso, C., Sealls, W., & Fahrbach, J. L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60976-4 · Cited by 486 · see citing works
Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14843 · Cited by 454 · see citing works
Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk
Chia, C. W., Egan, J. M., & Ferrucci, L. (2018) · Circulation Research · doi:10.1161/circresaha.118.312806 · Cited by 454 · see citing works
Self-citationRole of the Vagus Nerve in Mediating Proximal Nutrient-Induced Glucagon-Like Peptide-1 Secretion*
Rocca, A. S., & Brubaker, P. L. (1999) · Endocrinology · doi:10.1210/endo.140.4.6643 · Cited by 452 · see citing works
Blevins, T., Pullman, J., Malloy, J., Yan, P., Taylor, K., Schulteis, C., Trautmann, M., & Porter, L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2081 · Cited by 448 · see citing works
Kim, D. S., MacConell, L., Zhuang, D., Kothare, P. A., TRAUTMANN, M. E., Fineman, M. S., & Taylor, K. (2007) · Diabetes Care · doi:10.2337/dc06-2375 · Cited by 447 · see citing works
Vilsbøll, T., Agersø, H., Krarup, T., & Holst, J. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021053 · Cited by 444 · see citing works
The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man.
Spiller, R. E., Trotman, I. F., Higgins, B. E., Ghatei, M. A., GRIMBLE, G. K., Lee, Y. C., Bloom, S. R., Misiewicz, J. J., & Silk, D. B. A. (1984) · Gut · doi:10.1136/gut.25.4.365 · Cited by 443 · see citing works
Deacon, C. F., Nauck, M. A., Meier, J. J., Hücking, K., & Holst, J. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6855 · Cited by 439 · see citing works
Kolterman, O., Kim, D. D. H., Shen, L. Z., Ruggles, J. A., Nielsen, L. L., Fineman, M. S., & Baron, A. (2005) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/62.2.173 · Cited by 434 · see citing works
Degn, K. B., Juhl, C. B., Sturis, J., Jakobsen, G., Brock, B., Chandramouli, V., Rungby, J., Landau, B. R., & Schmitz, O. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1187 · Cited by 427 · see citing works
Gastric emptying and release of incretin hormones after glucose ingestion in humans.
Schirra, J., Katschinski, M., Weidmann, C., Schäfer, T., Wank, U., Arnold, R., & Göke, B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118411 · Cited by 426 · see citing works
Tracy, M. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00002-2 · Cited by 411 · see citing works
Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, J. J., & Ferrannini, E. (2008) · Diabetes · doi:10.2337/db07-1315 · Cited by 409 · see citing works
Wysham, C., Blevins, T., Arakaki, R., Colon, G., Garcia, P., Atisso, C., Kuhstoss, D., & Lakshmanan, M. (2014) · Diabetes Care · doi:10.2337/dc13-2760 · Cited by 396 · see citing works
Attenuated GLP-1 secretion in obesity: cause or consequence
Ranganath, L. R., Beety, J. M., Morgan, L. M., Wright, J. W., Howland, R., & Marks, V (1996) · Gut · doi:10.1136/gut.38.6.916 · Cited by 394 · see citing works
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP
Theodorakis, M. J., Carlson, O. D., Michopoulos, S., Doyle, M. E., Juhaszova, M., Petraki, K., & Egan, J. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00326.2004 · Cited by 391 · see citing works
Self-citationChu, Z., Carroll, C., Alfonso, J., Gutierrez, V., He, H., Lucman, A., Pedraza, M., Mondala, H., Gao, H., Bagnol, D., et al. (2008) · Endocrinology · doi:10.1210/en.2007-0966 · Cited by 387 · see citing works
Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit
Wichmann, A., Allahyar, A., Greiner, T. U., Plovier, H., Östergren‐Lundén, G., Larsson, T. P., Drucker, D. J., Delzenne, N. M., Cani, P. D., & Bäckhed, F. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.09.012 · Cited by 382 · see citing works
Habib, A. M., Richards, P., Cairns, L. S., Rogers, G. J., Bannon, C. A. M., Parker, H. E., Morley, T. C. E., Yeo, G. S. H., Reimann, F. M., & Gribble, F. M. (2012) · Endocrinology · doi:10.1210/en.2011-2170 · Cited by 382 · see citing works
Cefalu, W. T., Kaul, S., Gerstein, H. C., Holman, R. R., Zinman, B., Skyler, J. S., Green, J. B., Buse, J. B., Inzucchi, S. E., Leiter, L. A., et al. (2017) · Diabetes Care · doi:10.2337/dci17-0057 · Cited by 382 · see citing works
Bettge, K., Kahle, M., Abd El Aziz, M. S., Meier, J. J., & Nauck, M. A. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12824 · Cited by 374 · see citing works
Pancreatic Safety of Incretin-Based Drugs — FDA and EMA Assessment
(2014) · New England Journal of Medicine · doi:10.1056/nejmx140026 · Cited by 372 · see citing works
Meier, J. J., Gallwitz, B., Salmen, S., Goetze, O., Holst, J. J., Schmidt, W. E., & Nauck, M. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030049 · Cited by 369 · see citing works
Endocannabinoids–at the crossroads between the gut microbiota and host metabolism
Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.211 · Cited by 367 · see citing works
GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
Mortensen, K., Lundby‐Christensen, L., Holst, J. J., & Ørskov, C. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00125-3 · Cited by 360 · see citing works
DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks
Buse, J. B., Drucker, D. J., Taylor, K., Kim, T., Walsh, B., Hu, H., Wilhelm, K., TRAUTMANN, M. E., Shen, L. Z., Porter, L. E., et al. (2010) · Diabetes Care · doi:10.2337/dc09-1914 · Cited by 357 · see citing works
Vollmer, K., Holst, J. J., Baller, B., Ellrichmann, M., Nauck, M. A., Schmidt, W. E., & Meier, J. J. (2007) · Diabetes · doi:10.2337/db07-1124 · Cited by 353 · see citing works
A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence
Brown, J. C., & Dryburgh, J. R. (1971) · Canadian Journal of Biochemistry · doi:10.1139/o71-122 · Cited by 344 · see citing works
Korner, J., Bessler, M., Inabnet, W., Taveras, C., & Holst, J. J. (2007) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2007.08.004 · Cited by 344 · see citing works
Verdich, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.9.4382 · Cited by 340 · see citing works
Jin, S.-L. C., Han, V. K. M., Simmons, J. G., Towle, A. C., Lauder, J. M., & Lund, P. K. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902710405 · Cited by 335 · see citing works
Meier, J. J., Nauck, M. A., Kranz, D., Holst, J. J., Deacon, C. F., Gaeckler, D., Schmidt, W. E., & Gallwitz, B. (2004) · Diabetes · doi:10.2337/diabetes.53.3.654 · Cited by 334 · see citing works
Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice
Tschen, S.-I., Dhawan, S., Gurlo, T., & Bhushan, A. (2009) · Diabetes · doi:10.2337/db08-1651 · Cited by 331 · see citing works
Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E., Olsen, J., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1595 · Cited by 328 · see citing works
Pratley, R. E., Nauck, M. A., Barnett, A. H., Feinglos, M. N., Ovalle, F., Harman-Boehm, I., Ye, J., Scott, R., Johnson, S., Stewart, M., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70214-6 · Cited by 326 · see citing works
Parker, H. E., Habib, A. M., Rogers, G. J., Gribble, F. M., & Reimann, F. (2009) · Diabetologia · doi:10.1007/s00125-008-1202-x · Cited by 324 · see citing works
Færch, K., Torekov, S. S., Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, A., Pedersen, O., Hansen, T., Lauritzen, T., Sandbæk, A., et al. (2015) · Diabetes · doi:10.2337/db14-1751 · Cited by 321 · see citing works
Frias, J. P., Bastyr, E. J., Vignati, L., Tschöp, M. H., Schmitt, C., Owen, K., Christensen, R. H., & DiMarchi, R. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.011 · Cited by 321 · see citing works
Meier, J. J., Gallwitz, B., Siepmann, N., Holst, J. J., Deacon, C. F., Schmidt, W. E., & Nauck, M. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1103-y · Cited by 314 · see citing works
Elahi, D., McAloon-Dyke, M., Fukagawa, N. K., Meneilly, G. S., Sclater, A. L., Minaker, K. L., Habener, J. F., & Andersen, D. K. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90136-8 · Cited by 308 · see citing works
Näslund, E. B., Gutniak, M., Skogar, S., Rössner, S., & Hellström, P. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.3.525 · Cited by 307 · see citing works
Glaesner, W., Vick, A., Millican, R. L., Ellis, B., Tschang, S., Tian, Y., Bokvist, K. B., Brenner, M. B., Köester, A., Pørksen, N. K., et al. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1080 · Cited by 305 · see citing works
Review of head‐to‐head comparisons of glucagon‐like peptide‐1 receptor agonists
Madsbad, S. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12596 · Cited by 305 · see citing works
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
Lund, P. K., Goodman, R. H., Dee, P. C., & Habener, J. F. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.345 · Cited by 295 · see citing works
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
Hansotia, T., Maida, A., Flock, G., Yamada, Y., Tsukiyama, K., Seino, Y., & Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci25483 · Cited by 290 · see citing works
Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM
Nauck, M. A., Wollschläger, D., Werner, J., Holst, J. J., Ørskov, C., Creutzfeldt, W., & Willms, B. (1996) · Diabetologia · doi:10.1007/s001250050613 · Cited by 283 · see citing works
All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons
Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 281 · see citing works
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
Beumer, J., Artegiani, B., Post, Y., Reimann, F. M., Gribble, F. M., Nguyen, T. N., Zeng, H., van den Born, M., van Es, J. H., & Clevers, H. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0143-y · Cited by 280 · see citing works
Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Jacobsen, S. H., Worm, D., Hansen, D. L., Kristiansen, V. B., Naver, L., Madsbad, S., & Holst, J. J. (2013) · Diabetes · doi:10.2337/db13-0022 · Cited by 279 · see citing works
On the treatment of <i>Diabetus mellitus</i> by acid extract of Duodenal Mucous Membrane
Moore, B., Edie, E. S., & Abram, J. H. (1906) · Biochemical Journal · doi:10.1042/bj0010028 · Cited by 279 · see citing works
Glucagon gene expression in vertebrate brain.
Drucker, D. J., & Asa, S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68261-4 · Cited by 265 · see citing works
Rachman, J., Barrow, B. A., Lévy, J., & Turner, R. C. (1997) · Diabetologia · doi:10.1007/s001250050664 · Cited by 265 · see citing works
Ma, J., Bellon, M., Wishart, J. M., Young, R. L., Blackshaw, L. A., Jones, K. L., Horowitz, M., & Rayner, C. K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90708.2008 · Cited by 256 · see citing works
Steinert, R. E., Frey, F., Töpfer, A., Drewe, J., & Beglinger, C. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000512x · Cited by 255 · see citing works
Rosenstock, J., Raccah, D., Korányi, L., Maffei, L., Boka, G., Miossec, P., & Gerich, J. E. (2013) · Diabetes Care · doi:10.2337/dc12-2709 · Cited by 253 · see citing works
Calanna, S., Christensen, M., Holst, J. J., Laferrère, B., Gluud, L. L., Vilsbøll, T., & Knop, F. K. (2013) · Diabetologia · doi:10.1007/s00125-013-2841-0 · Cited by 251 · see citing works
Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas
Tornehave, D., Kristensen, P., Rømer, J., Knudsen, L. B., & Heller, R. S. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2008.951319 · Cited by 248 · see citing works
Gastric Inhibitory Polypeptide: Its Physiologic Release and Insulinotropic Action in the Dog
Pederson, R. A., Schubert, H., & Brown, J. C. (1975) · Diabetes · doi:10.2337/diab.24.12.1050 · Cited by 245 · see citing works
Radioimmunoassay for Gastric Inhibitory Polypeptide
Kuzio, M. D., Dryburgh, J. R., Malloy, K. M., & Brown, J. C. (1974) · Gastroenterology · doi:10.1016/s0016-5085(74)80134-4 · Cited by 241 · see citing works
Oral Glucose Augmentation of Insulin Secretion
Andersen, D. K., Elahi, D., Brown, J. C., Tobin, J. D., & Andres, R. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109100 · Cited by 239 · see citing works
The Role of GLP-1 in the Metabolic Success of Bariatric Surgery
Hutch, C. R., & Sandoval, D. A. (2017) · Endocrinology · doi:10.1210/en.2017-00564 · Cited by 238 · see citing works
Functional GIP Receptors Are Present on Adipocytes
Yip, R. G.-C., Boylan, M. O., Kieffer, T. J., & Wolfe, M. M. (1998) · Endocrinology · doi:10.1210/endo.139.9.6288 · Cited by 237 · see citing works
Meier, J. J., Hücking, K., Holst, J. J., Deacon, C. F., Schmiegel, W., & Nauck, M. A. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2497 · Cited by 230 · see citing works
Hupe-Sodmann, K., McGregor, G. P., Bridenbaugh, R., Göke, R., Göke, B., Thole, H., Zimmermann, B., & Voigt, K. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(95)00063-h · Cited by 224 · see citing works
Gastric Inhibitory Polypeptide Enhanced Lipoprotein Lipase Activity in Cultured Preadipocytes
Eckel, R. H., Fujimoto, W. Y., & Brunzell, J. D. (1979) · Diabetes · doi:10.2337/diab.28.12.1141 · Cited by 219 · see citing works
Efficacy and Safety of the Once-Daily GLP-1 Receptor Agonist Lixisenatide in Monotherapy
Fonseca, V. A., Alvarado-Ruiz, R., Raccah, D., Boka, G., Miossec, P., Gerich, J. E., & on behalf of the EFC6018 GetGoal-Mono Study Investigators (2012) · Diabetes Care · doi:10.2337/dc11-1935 · Cited by 218 · see citing works
Schauer, P. R., Mingrone, G., Ikramuddin, S., & Wolfe, B. (2016) · Diabetes Care · doi:10.2337/dc16-0382 · Cited by 215 · see citing works
Creutzfeldt, W., Ebert, R., Willms, B., Frerichs, H., & Brown, J. C. (1978) · Diabetologia · doi:10.1007/bf00429703 · Cited by 211 · see citing works
Buchan, A. M. J., Polak, J. M., Capella, C., Solcia, E., & Pearse, A. G. E. (1978) · Histochemistry and Cell Biology · doi:10.1007/bf00492251 · Cited by 210 · see citing works
GLP‐1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
Egan, J. M., Bulotta, A., Hui, H., & Perfetti, R. (2003) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.357 · Cited by 208 · see citing works
Self-citationMatthews, J. E., Stewart, M. W., Boever, E. H. D., Dobbins, R. L., Hodge, R. J., Walker, S. E., Holland, M. C., Bush, M., & for the Albiglutide Study Group (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1518 · Cited by 198 · see citing works
Mentis, N., Vardarli, I., Köthe, L. D., Holst, J. J., Deacon, C. F., Theodorakis, M., Meier, J. J., & Nauck, M. A. (2011) · Diabetes · doi:10.2337/db10-1332 · Cited by 197 · see citing works
Ford, H. E., Peters, V., Martin, N. M., Sleeth, M., Ghatei, M. A., Frost, G. S., & Bloom, S. R. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.291 · Cited by 196 · see citing works
Gasbjerg, L. S., Helsted, M. M., Hartmann, B., Jensen, M. H., Gabe, M. B. N., Sparre-Ulrich, A. H., Veedfald, S., Stensen, S., Lanng, A. R., Bergmann, N. C., et al. (2019) · Diabetes · doi:10.2337/db18-1123 · Cited by 193 · see citing works
Kapitza, C., Forst, T. M., Coester, H. V., Poitiers, F., Ruus, P., & Hincelin-Méry, A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12076 · Cited by 192 · see citing works
Nyberg, J., Anderson, M. F., Meister, B., Alborn, A.-M., Ström, A.-K., Brederlau, A., Illerskog, A.-C., Nilsson, O., Kieffer, T. J., Hietala, M. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4920-04.2005 · Cited by 191 · see citing works
Granhall, C., Donsmark, M., Blicher, T. M., Golor, G., Søndergaard, F. L., Thomsen, M., & Bækdal, T. A. (2019) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-0728-4 · Cited by 190 · see citing works
Panunzi, S., Gaetano, A. D., Carnicelli, A., & Mingrone, G. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000863 · Cited by 189 · see citing works
Kim, S.-J., Nian, C., Karunakaran, S., Clee, S. M., Isales, C. M., & McIntosh, C. H. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040156 · Cited by 182 · see citing works
Althage, M. C., Ford, E. L., Wang, S., Tso, P., Polonsky, K. S., & Wice, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710466200 · Cited by 180 · see citing works
Glucagon-Like Peptide-1: Glucose Homeostasis and Beyond
Cho, Y. M., Fujita, Y., & Kieffer, T. J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170315 · Cited by 176 · see citing works
Clements, R. H., González, Q. H., Long, C. L., Wittert, G., & Laws, H. L. (2004) · The American Surgeon · doi:10.1177/000313480407000101 · Cited by 176 · see citing works
Chia, C. W., Carlson, O. D., Kim, W., Shin, Y., Charles, C. P., Kim, H. S., Melvin, D. L., & Egan, J. M. (2009) · Diabetes · doi:10.2337/db08-0958 · Cited by 174 · see citing works
Self-citationEnteroendocrine K and L cells in healthy and type 2 diabetic individuals
Jorsal, T., Rhee, N. A., Pedersen, J., Wahlgren, C. D., Mortensen, B., Jepsen, S. L., Jelsing, J., Dalbøge, L. S., Vilmann, P., Hassan, H., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4450-9 · Cited by 174 · see citing works
Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus
Rubino, F., R'bibo, S. L., del Genio, F., Mazumdar, M., & McGraw, T. E. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.268 · Cited by 173 · see citing works
Chapter 15 Glucose‐Dependent Insulinotropic Polypeptide (Gastric Inhibitory Polypeptide; GIP)
McIntosh, C. H. S., Widenmaier, S. B., & Kim, S. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(08)00615-8 · Cited by 172 · see citing works
Gault, V. A., Irwin, N., Green, B. D., McCluskey, J. T., Greer, B., Bailey, C. J., Harriott, P., O'Harte, F. P. M., & Flatt, P. R. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2436 · Cited by 172 · see citing works
Smith, E. P., An, Z., Wagner, C., Lewis, A. G., Cohen, E. B., Li, B., Mahbod, P., Sandoval, D. A., Pérez–Tilve, D., Tamarina, N. A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.005 · Cited by 165 · see citing works
Anini, Y., Hansotia, T., & Brubaker, P. L. (2002) · Endocrinology · doi:10.1210/endo.143.6.8840 · Cited by 158 · see citing works
Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes
Calanna, S., Christensen, M., Holst, J. J., Laferrère, B., Gluud, L. L., Vilsbøll, T., & Knop, F. K. (2013) · Diabetes Care · doi:10.2337/dc13-0465 · Cited by 158 · see citing works
Jendle, J., Grunberger, G., Blevins, T., Giorgino, F., Hietpas, R. T., & Botros, F. T. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2810 · Cited by 158 · see citing works
Salinari, S., BERTUZZI, A., Asnaghi, S., Guidone, C., Manco, M., & Mingrone, G. (2008) · Diabetes Care · doi:10.2337/dc08-1314 · Cited by 157 · see citing works
PEDERSON, R. A., & BROWN, J. C. (1978) · Endocrinology · doi:10.1210/endo-103-2-610 · Cited by 156 · see citing works
Generation of L Cells in Mouse and Human Small Intestine Organoids
Petersen, N., Reimann, F. M., Bartfeld, S., Farin, H. F., Ringnalda, F. C. A. S., Vries, R. G. J., van den Brink, S., Clevers, H. C., Gribble, F. M., & de Koning, E. J. P. (2013) · Diabetes · doi:10.2337/db13-0991 · Cited by 156 · see citing works
Moriya, R., Shirakura, T., Ito, J., Mashiko, S., & Seo, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00412.2009 · Cited by 156 · see citing works
Storgaard, H., Cold, F., Gluud, L. L., Vilsbøll, T., & Knop, F. K. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12885 · Cited by 155 · see citing works
Buse, J. B., Garber, A. J., Rosenstock, J., Schmidt, W. E., Brett, J., Videbæk, N., Holst, J. J., & Nauck, M. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2822 · Cited by 154 · see citing works
Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.
Wasada, T., McCorkle, K., Harris, V., Kawai, K., Howard, B. V., & Unger, R. H. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110335 · Cited by 153 · see citing works
Fujita, Y., Wideman, R. D., Asadi, A., Yang, G. K., Baker, R. K., Webber, T. D., Zhang, T., Wang, R., Ao, Z., Warnock, G. L., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.049 · Cited by 152 · see citing works
Fineman, M. S., Mace, K. F., Diamant, M., Darsow, T., Cirincione, B. B., Porter, T. K. B., Kinninger, L. A., & TRAUTMANN, M. E. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01561.x · Cited by 152 · see citing works
Tseng, C., Kieffer, T. J., Jarboe, L. A., Usdin, T. B., & Wolfe, M. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119060 · Cited by 149 · see citing works
pH regulation in barnacle muscle fibers: dependence on intracellular and extracellular pH
Boron, W. F., McCormick, W. C., & Roos, A. D. G. D. (1979) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1979.237.3.c185 · Cited by 149 · see citing works
Lorenz, M., Pfeiffer, C., Steinstraesser, A., Becker, R. H. A., Rütten, H., Ruus, P., & Horowitz, M. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.04.001 · Cited by 147 · see citing works
Deacon, C. F., Danielsen, P. L., Klarskov, L., Olesen, M., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1588 · Cited by 145 · see citing works
Direct effect of GLP-1 infusion on endogenous glucose production in humans
Seghieri, M., Rebelos, E., Gastaldelli, A., Astiarraga, B. D., Casolaro, A., Barsotti, E., Pocai, A., Nauck, M., Muscelli, E., & Ferrannini, E. (2013) · Diabetologia · doi:10.1007/s00125-012-2738-3 · Cited by 143 · see citing works
TCF1 links GIPR signaling to the control of beta cell function and survival
Campbell, J. E., Ussher, J. R., Mulvihill, E. E., Kolic, J., Baggio, L. L., Cao, X., Liu, Y., Lamont, B. J., Morii, T., Streutker, C. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.3997 · Cited by 142 · see citing works
Cleator, I. G. M., & Gourlay, R. H. (1975) · The American Journal of Surgery · doi:10.1016/0002-9610(75)90360-8 · Cited by 141 · see citing works
Vaccination against GIP for the Treatment of Obesity
Fulurija, A., Lutz, T. A., Sladko, K., Osto, M., Wielinga, P. Y., Bachmann, M. F., & Saudan, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003163 · Cited by 136 · see citing works
Simonsen, L., Holst, J. J., & Deacon, C. F. (2006) · Diabetologia · doi:10.1007/s00125-005-0128-9 · Cited by 133 · see citing works
Piteau, S., Olver, A., Kim, S.-J., Winter, K., Pospisilik, J. A., Lynn, F., Manhart, S., Demuth, H.-U., Speck, M., Pederson, R. A., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.115 · Cited by 130 · see citing works
Marbury, T. C., Flint, A., Jacobsen, J. B., Karsbøl, J. D., & Lasseter, K. C. (2017) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0528-2 · Cited by 130 · see citing works
Krarup, T., Saurbrey, N., Moody, A. J., Kühl, C., & Madsbad, S. (1987) · Metabolism · doi:10.1016/0026-0495(87)90153-3 · Cited by 128 · see citing works
Irwin, N., & Flatt, P. R. (2009) · Diabetologia · doi:10.1007/s00125-009-1422-8 · Cited by 125 · see citing works
Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study
Azoulay, L., Filion, K. B., Platt, R. W., Dahl, M., Dormuth, C. R., Clemens, K. K., Durand, M., Juurlink, D. N., Targownik, L. E., Turin, T. C., et al. (2016) · BMJ · doi:10.1136/bmj.i581 · Cited by 120 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [16]Brown JC & Pedersen RA. 1977. GI hormones and insulin secretion. In Proceedings of the 5th International Congress of Endocrinology, Vol. 2, 568– 570. Amsterdam: Excerpta Medica.
Cited by
Sorted by citations
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)
Do, A., Zahrawi, F. M., & Mehal, W. Z. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01084-2 · Cited by 188 · see citing works
Boutari, C., DeMarsilis, A. J., & Mantzoros, C. S. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110773 · Cited by 171 · see citing works
Yoshinari, Y., Kosakamoto, H., Kamiyama, T., Hoshino, R., Matsuoka, R., Kondo, S., Tanimoto, H., Nakamura, A., Obata, F., & Niwa, R. (2021) · Nature Communications · doi:10.1038/s41467-021-25146-w · Cited by 147 · see citing works
Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling
Wang, Q., Lin, H., Shen, C., Zhang, M., Wang, X., Yuan, M., Yuan, M., Jia, S., Cao, Z., Wu, C., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2274124 · Cited by 124 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Naya, I., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., Asúnsolo, Á., & de la Torre, B. (2020) · Nutrients · doi:10.3390/nu12092749 · Cited by 117 · see citing works
GLP-1a: Going beyond Traditional Use
Laurindo, L. F., Barbalho, S. M., Guiguer, E. L., da Silva Soares de Souza, M., de Souza, G. A., Fidalgo, T. M., Araújo, A. C., de Souza Gonzaga, H. F., de Bortoli Teixeira, D., de Oliveira Silva Ullmann, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020739 · Cited by 102 · see citing works
SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done?
Mazucanti, C. H., & Egan, J. M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00192-y · Cited by 66 · see citing works
Self-citationIncretin Hormones in Obesity and Related Cardiometabolic Disorders: The Clinical Perspective
Michałowska, J. M., Miller‐Kasprzak, E., & Bogdański, P. (2021) · Nutrients · doi:10.3390/nu13020351 · Cited by 69 · see citing works
Facciorusso, A., Ramai, D., Dhar, J., Samanta, J., Chandan, S., Gkolfakis, P., Crinò, S. F., Maida, M., Anderloni, A., Boskoski, I., et al. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.07.021 · Cited by 59 · see citing works
Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Biomolecules · doi:10.3390/biom11020286 · Cited by 56 · see citing works
“Conversely, in a state of obesity, GIP levels are elevated during both fasting and after an oral glucose challenge, whereas GLP-1 levels are unchanged during fasting and reduced in response to an oral glucose challenge [37].”
BackgroundKimura, Y., Yoshida, D., Hirakawa, Y., Hata, J., Honda, T., Shibata, M., Sakata, S., Uchida, K., Kitazono, T., & Ninomiya, T. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13377 · Cited by 46 · see citing works
Cremonini, E., Daveri, E., Mastaloudis, A., & Oteiza, P. I. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab029 · Cited by 43 · see citing works
Satiety Associated with Calorie Restriction and Time-Restricted Feeding: Peripheral Hormones
Tacad, D. K., Tovar, A. P., Richardson, C. E., Horn, W. F., Krishnan, G. P., Keim, N. L., & Krishnan, S. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac014 · Cited by 44 · see citing works
Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs
Wang, L., Zhu, L., Meister, J., Bone, D. B. J., Pydi, S. P., Rossi, M., & Wess, J. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030220-121042 · Cited by 36 · see citing works
Colca, J. R., & Scherer, P. E. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101409 · Cited by 37 · see citing works
de, A. P.-M., Pellitero, S., & Puig‐Domingo, M. (2021) · Minerva Endocrinology · doi:10.23736/s2724-6507.20.03369-6 · Cited by 36 · see citing works
Chapman, M. B., Norwood, D. A., Price, C., Abdulhadi, B., Baig, K. R. K. K., Ahmed, A. M., Peter, S., Routman, J. S., Sánchez‐Luna, S. A., Duggan, E. W., et al. (2024) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2024.05.012 · Cited by 33 · see citing works
Amylin: From Mode of Action to Future Clinical Potential in Diabetes and Obesity
Volčanšek, Š., Koceva, A., Jensterle, M., Janež, A., & Muzurović, E. M. (2025) · Diabetes Therapy · doi:10.1007/s13300-025-01733-8 · Cited by 31 · see citing works
Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy
Fröhlich, J., Chaldakov, G. N., & Vinciguerra, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084137 · Cited by 26 · see citing works
Effect of liraglutide 3.0mg treatment on weight reduction in obese antipsychotic-treated patients
Lee, S. E., Lee, N. Y., Kim, S. H., Kim, K.-A., & Kim, Y. S. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113830 · Cited by 27 · see citing works
Insulin: A connection between pancreatic β cells and the hypothalamus
de la Cruz-Concepción, B., Flores-Cortez, Y. A., Barragán-Bonilla, M. I., Mendoza-Bello, J. M., & Espinoza-Rojo, M. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i2.76 · Cited by 25 · see citing works
Płatek, T., Polus, A., Góralska, J., Raźny, U., Gruca, A., Kieć‐Wilk, B., Zabielski, P., Kapusta, M., Słowińska-Solnica, K., Solnica, B., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00220-z · Cited by 25 · see citing works
Resveratrol Affects Insulin Signaling in Type 2 Diabetic Goto-Kakizaki Rats
Szkudelska, K., Deniziak, M., Sassek, M., Szkudelski, I., Noskowiak, W., & Szkudelski, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052469 · Cited by 25 · see citing works
TRPA1: Pharmacology, natural activators and role in obesity prevention
Mahajan, N. S., Khare, P., Kondepudi, K. K., & Bishnoi, M. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174553 · Cited by 25 · see citing works
Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
Pan, Y., Bu, T., Deng, X., Jia, J., & Yuan, G. (2024) · Endocrine · doi:10.1007/s12020-023-03640-z · Cited by 27 · see citing works
Glucagon-Like Peptide 1: An Introduction and Possible Implications for Neuropsychiatry
López-Ojeda, W., & Hurley, R. A. (2024) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20230226 · Cited by 24 · see citing works
Liraglutide improves lipid and carbohydrate metabolism of ovariectomized rats
Model, J. F. A., Lima, M. V., Ohlweiler, R., Vogt, É. L., Rocha, D. S., de Souza, S. K., Türck, P., Araújo, A. S. D. R., & Vinagre, A. S. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111158 · Cited by 23 · see citing works
Kim, J. Y., Tfayli, H. M., Bacha, F. F., Lee, S., Michaliszyn, S. F., Yousuf, S., Gebara, N. Y., & Arslanian, S. A. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12940 · Cited by 21 · see citing works
Ko, J., Fonseca, V. A., & Wu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098283 · Cited by 19 · see citing works
The role of incretin receptor agonists in the treatment of obesity
Forst, T. M., Block, C. E. M. D., Prato, S. D., Armani, S., Frías, J. P., Lautenbach, A., Ludvik, B. H., Marinez, M., Mathieu, C., Müller, T. D., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15796 · Cited by 20 · see citing works
Meister, J., Wang, L., Pydi, S. P., & Wess, J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15314 · Cited by 21 · see citing works
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
Rosenberg, J., Jacob, J., Desai, P., Park, J., Donovan, L., & Kim, J. Y. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes21053 · Cited by 17 · see citing works
Li, H., Yuan, W., Tian, Y., Tian, F., Wang, Y., Sun, X., & Gong, Y. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109269 · Cited by 17 · see citing works
Fahim, S. A., Attia, Y. M., Messiha, A. A., Nabawy, A. Y., Refaat, F., & El-Maadawy, W. H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118731 · Cited by 19 · see citing works
Xie, Y., Zhou, Q., He, Q., Wang, X., & Wang, J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.008 · Cited by 16 · see citing works
Liu, Q., Aseer, K. R., Yao, Q., Zhong, X., Ghosh, P., O’Connell, J. F., & Egan, J. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.809965 · Cited by 16 · see citing works
Self-citationIncretins as a Potential Treatment Option for Gestational Diabetes Mellitus
Pilszyk, A., Niebrzydowska-Tatus, M., Pilszyk, Z., Wierzchowska-Opoka, M., & Kimber-Trojnar, Ż. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710101 · Cited by 14 · see citing works
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals
Model, J. F. A., Rocha, D. S., Fagundes, A. D. C., & Vinagre, A. S. (2022) · Veterinary and Animal Science · doi:10.1016/j.vas.2022.100245 · Cited by 14 · see citing works
Cardiovascular effects of GLP-1 receptor agonism
Winquist, R. J., & Gribkoff, V. K. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2022.02.005 · Cited by 13 · see citing works
G protein-coupled receptors and obesity
Pocai, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1301017 · Cited by 14 · see citing works
Drug Repositioning in Friedreich Ataxia
Rufini, A., Malisan, F., Condò, I., & Testi, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.814445 · Cited by 13 · see citing works
Flis, M., Rodziewicz-Flis, E. A., Micielska, K., Kortas, J. A., Jaworska, J., Borkowska, A., Sansoni, V., Perego, S., Lombardi, G., & Ziemann, E. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5015 · Cited by 13 · see citing works
Zuñiga-Martínez, B. S., Domínguez-Avila, J. A., Montiel‐Herrera, M., Villegas‐Ochoa, M. A., Robles-Sánchez, R. M., Ayala-Zavala, J. F., Viuda‐Martos, M., & González-Aguilar, G. A. (2024) · Foods · doi:10.3390/foods13223640 · Cited by 11 · see citing works
Aravindhan, V., & Yuvaraj, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1303338 · Cited by 10 · see citing works
Food regulation of incretin axis: Molecular mechanisms and clinical outlook in diabetes
Huang, Q., Deng, H., Sun, M.-C., & Zhao, C. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105326 · Cited by 8 · see citing works
Kausar, M. A., Shahid, S., Anwar, S., Kuddus, M., Khan, M. K. A., Alotaibi, A. D., & Arif, J. M. (2022) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.56.1s.39 · Cited by 9 · see citing works
Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid
Fernandes, M. F., Tomczewski, M. V., & Duncan, R. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084163 · Cited by 8 · see citing works
Nuszkiewicz, J., Czuczejko, J., Dróżdż, W., Woźniak, A., Małkowski, B., & Szewczyk‐Golec, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043283 · Cited by 8 · see citing works
Mussels as sustainable marine resources for bioactive peptides for health and the food industry
Suryaningtyas, I. T., Jasmadi, Dayarathne, L. A., Marasinghe, C. K., & Je, J. (2025) · Food & Function · doi:10.1039/d4fo05397d · Cited by 7 · see citing works
Odongo, K., Hironao, K.-Y., Yamashita, Y., & Ashida, H. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-78 · Cited by 7 · see citing works
Kabadi, U. M. (2021) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2021.113007 · Cited by 7 · see citing works
Janot, C., Fourati, S., Bernard, A., Besnard, P., Gall, M. L., Ledoux, S., & Beyec, J. L. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.09.014 · Cited by 6 · see citing works
Hassanzadeh-Rostami, Z., Ghobadi, S., & Faghih, S. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac056 · Cited by 6 · see citing works
Lipid regulation of the glucagon receptor family
Oqua, A. I., Manchanda, Y., McGlone, E. R., Jones, B. J., Rouse, S. L., & Tomás, A. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0335 · Cited by 6 · see citing works
Can omega-3 fatty acids and vitamin E co-supplementation affect obesity indices?
Musazadeh, V., Tandorost, A., Zarezadeh, M., Jafarzadeh, J., Ghavami, Z., Jamilian, P., & Ostadrahimi, A. (2022) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000757 · Cited by 6 · see citing works
Song, L., Wang, X., Yang, Z., Kong, X., Chen, X., Zhang, B., & Yang, W. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i11.514 · Cited by 6 · see citing works
The Gut Microbiome’s Influence on Incretins and Impact on Blood Glucose Control
Dulai, A. S., Min, M., & Sivamani, R. K. (2024) · Biomedicines · doi:10.3390/biomedicines12122719 · Cited by 6 · see citing works
Alade, A. A., Ahmed, S. A., Mujwar, S., Kikiowo, B., Akinnusi, P. A., Olubode, S. O., Olufemi, O. M., & Ohilebo, A. A. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2217927 · Cited by 5 · see citing works
Wang, Q., Kong, P., Wang, Q., Ruan, J., Yang, W., Teng, X., & Guo, Y. (2026) · The FASEB Journal · doi:10.1096/fj.202502063r · Cited by 4 · see citing works
Zhang, D., Wen, Z., Jiang, T., & Sun, Y. (2021) · Peptides · doi:10.1016/j.peptides.2021.170595 · Cited by 4 · see citing works
Singh, P., Verma, K., Dixit, J., Rai, V., Narayan, G., Tiwari, K. N., Singh, A. K., Singh, J., & Ashutosh, K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100193 · Cited by 4 · see citing works
Zoubiri, H., Saiah, W., Otmane, A., Saidi, H., Makrelouf, M., Abderrahman, S. A., Haddam, A. E. M., & Koceir, E.-A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031218 · Cited by 3 · see citing works
Fernandes, M. F., Aristizabal‐Henao, J. J., Marvyn, P. M., M’Hiri, I., Wiens, M. A., Hoang, M., Sebastian, M., Nachbar, R. T., St‐Pierre, P., Silva, K. D. D., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101887 · Cited by 3 · see citing works
Ameliorating implications of Psidium guajava L. (guava) leaf against metabolic syndromes—A review
Ahmad, M., Munir, S., Islam, M. U., Imran, S., Hafeez, M. A., Raza, M. A., Abdi, G., & Aadil, R. M. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101867 · Cited by 3 · see citing works
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac134.376 · Cited by 3 · see citing works
Fraga, C. G., Cremonini, E., Galleano, M., & Oteiza, P. I. (2024) · Handbook of experimental pharmacology · doi:10.1007/164_2024_707 · Cited by 3 · see citing works
Drozdovska, S., Валеріївна, А. О., Orlenko, V., Andrieiev, I., Pastukhova, V., Mazur, I. I., Hurenko, O. O., & Nahorna, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105094 · Cited by 3 · see citing works
TRPA1 in obesity and insulin resistancePreprint
Mahajan, N. S., Khare, P., Kondepudi, K. K., & Bishnoi, M. (2020) · doi:10.22541/au.160684232.26505749/v1 · Cited by 3 · see citing works
Novel Treatments and the Future of DKD: What Is on the Horizon?
Wu, H., & Batuman, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-86020-2_28 · Cited by 2 · see citing works
Sangsuriyothai, P., Watari, I., Serirukchutarungsee, S., Satrawaha, S., Podyma‐Inoue, K. A., & Ono, T. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1357730 · Cited by 2 · see citing works
Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity
Overholser, A., Czech, E. J., Speer, L., Wilson, J., & Overholser, A. (2025) · Translation The University of Toledo Journal of Medical Sciences · doi:10.46570/utjms-2024-1218 · Cited by 1 · see citing works
Rosenberg, J., Williams, A. N., Gano, A., Deak, M. M., Shaibi, G. Q., & Kim, J. Y. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.109228 · Cited by 1 · see citing works
Sedibe, A., Sibiya, N., Nyakudya, T., & Gamede, M. W. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102345 · Cited by 1 · see citing works
Progress of New Drugs and Drugs in Research for Obesity Treatment
张, 小. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.1111758 · Cited by 1 · see citing works
Breit, A., & Gudermann, T. W. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02454-6 · Cited by 1 · see citing works
Xie, Y., He, Q., Wang, X., & Wang, J. (2024) · doi:10.22541/au.170670903.33408087/v1 · Cited by 1 · see citing works
Inter- and intra-individual variability of active glucagon-like peptide 1 among healthy adults
Sylvetsky, A. C., Bauman, V., Abdelhadi, J., Blau, J. E., Wilkins, K. J., & Rother, K. I. (2020) · Journal of Translational Science · doi:10.15761/jts.1000404
BARBQTCM Survey: Einfluss von Schlafstörungen auf die TCM-Akzeptanz bei Übergewicht und Adipositas
Panhofer, P., Vlasak, T., Pfefferkorn, U., Stockert, K., Bijak, M., Stockenhuber, D., & Rothe, S. (2021) · Deutsche Zeitschrift für Akupunktur · doi:10.1007/s42212-020-00343-8
Glp-1 Analogs for the Treatment of Obesity and Diabetes
Belloni, J., & Tapper, X. (2022) · Endocrinology and Disorders · doi:10.31579/2640-1045/116
Glucagon-like peptide 1 in patients with type 2 diabetes mellitus on insulin therapy
Lisker, A. V., Семикова, Г. В., & Volkova, A. R. (2022) · Endocrinology News Opinions Training · doi:10.33029/2304-9529-2022-11-2-9-13
L’intestin un organe endocrine : de la physiologie aux implications thérapeutiques en nutrition
Beyec, J. L., Ledoux, S., Coëffier, M., & Gall, M. L. (2022) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2021.12.179
Abbas, A., Mektebi, A., El-Gayar, R. M., Hamad, A. A., Hefnawy, M. T., Rady, A. H. A., Ballut, O. O., Moawad, M. H. E. D., Elsayed, M., & Schönfeldt‐Lecuona, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3150409/v1
New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system
Łupina, M., & Listos, J. (2023) · Current Issues in Pharmacy and Medical Sciences · doi:10.2478/cipms-2023-0040
Weight loss medications: A new Pandora’s box?
Mohan, B. P. (2024) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2024.05.018
Han, F., Lu, J., Zhou, L., Liu, Q., Ding, M., Liu, W., & Han, J. (2025) · npj Science of Food · doi:10.1038/s41538-025-00486-9
Płatek, T., Polus, A., Góralska, J., Raźny, U., Gruca, A., Kieć-Wilk, B., Zabielski, P., Kapusta, M., Słowińska-Solnica, K., Solnica, B., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13064412
Exploring the Role of Gut Microbiota in Diabetes and Colorectal Cancer
Sennie, N. S., Nambidi, S., Ashiq Shibili, P., Banerjee, A., & Radhakrishnan, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-5651-9_7
Li, M., Hu, H., Liu, Y., Wu, X., Zhang, Y., Li, Y., Yang, F., Li, Y., & Lin, S. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1794931
Mohammad, A., DASHTI, M. H., Malik, M. Z., Rajan, R., & Al‐Mulla, F. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153525
Yin, M., Guo, S., Gu, J., Zhang, Y. H., Yang, L., Zhang, Y. H., Zhang, X., Chang, X., Feng, S., Naiel, M. A. E., et al. (2026) · Journal of Fish Biology · doi:10.1111/jfb.70549
Abud, G. F., de Freitas, E. C., & Stanford, K. I. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00756-x
- Authors
- Chia, C. W., & Egan, J. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chia, Chee W.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2019-08-07
- Volume
- 1461
- Issue
- 1
- Pages
- 104-126
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC10131087
- OpenAlex
- W2968169723
- Cited by
- 93
- References
- 280
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 10 · 2022: 20 · 2021: 19 · 2020: 11 · 2019: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institute on Aging (Intramural Research Program)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- incretins, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, obesity, type 2 diabetes, GLP-1 receptor agonists, prediabetes, enteroendocrine cells, gut microbiota, endocannabinoid system, insulin secretion
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diabetes Mellitus, Type 2, Humans, Obesity, Guidelines as Topic, Incretins, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
