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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein

Yashiro, Takuya, Yokoi, Yuka, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro·2011·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2011.04.006
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Abstract

Human low-density lipoprotein receptor (LDLR) mRNA is unstable and contains four AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). The aim of this study was to verify the involvement of the 3'-UTR in the rapid degradation of LDLR mRNA. This study revealed that the 3'-UTR is necessary and sufficient for the degradation, and that the 1st ARE (ARE1) close to the stop codon associates with cytoplasmic proteins, and is primarily responsible for the degradation. Chenodeoxycholic acid (CDCA) treatment stabilized chimeric GFP-LDLR 3'-UTR mRNA and accompanied mitogen-activated protein kinase (MAPK) activation. The UV cross-linking assays showed that a protein of 80kDa increasingly binds to the region including the ARE1 in response to CDCA-mediated MAPK activation.

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Crossref · 10.1016/j.bbrc.2011.04.006

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Other studies have not been able to definitively identify a single cis-element responsible for the stabilizing effect on the LDLR 3′UTR, even after deletion of several different functional segments within the LDLR 3′UTR.

    “However, other studies have not been able to definitively identify a single cis-element responsible for this stabilizing effect on the LDLR 3′UTR, even after deletion of several different functional segments within the LDLR 3′UTR [19,32,41].”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [41]

  • LDLR 3′UTR contains cis-regulating elements that modulate the rate of LDLR mRNA degradation through interaction with trans-regulatory RNA binding proteins.

    “Embedded within the LDLR 3′UTR are several cis-regulating elements that modulate the rate of LDLR mRNA degradation through their interaction with trans-regulatory RNA binding proteins8,13.”

    From Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA (2018) · cites this paper as [13]

  • The LDLR mRNA 3′ UTR harbors four AU-rich elements (AREs) that are docking sites for cytoplasmic ARE-binding proteins.

    “This region harbors four adenylate-uridylate (AU)-rich elements (AREs)”

    From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [17]

Citations

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Research works printed but not linked: 17

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Metadata

Authors
Yashiro, T., Yokoi, Y., Shimizu, M., Inoue, J., & Sato, R.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2011-06
Volume
409
Issue
2
Pages
155-159
ISSN
0006-291X
DOI
10.1016/j.bbrc.2011.04.006
Cited by
18
References
1
Language
en
Licence
Funders
Ministry of Education, Culture, Sports, Science and Technology

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