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Cited by 152

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Extracellular Signal-Regulated Kinase–Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine

Abidi, Parveen, Zhou, Yue, Jiang, Jian-Dong, Liu, Jingwen·2005·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/01.atv.0000181761.16341.2b
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Abstract

Objective— Our recent studies identified berberine (BBR) as a novel cholesterol-lowering drug that upregulates low-density lipoprotein (LDL) receptor expression through mRNA stabilization. Here, we investigated mechanisms underlying regulatory effects of BBR on LDL receptor (LDLR) messenger. Methods and Results— We show that the extracellular signal-regulated kinase (ERK) signaling pathway is used primarily by BBR to attenuate the decay of LDLR mRNA in HepG2 cells. Using different reporter constructs, we demonstrate that BBR affects LDLR mRNA stability entirely through 3′ untranslated region (UTR) in an ERK-dependent manner, and this stabilizing effect is more prominent in liver-derived cells than nonhepatic cell lines. In contrast to BBR, the mRNA stabilizing effect of bile acid chenodeoxycholic acid is mediated through the LDLR coding sequence, whereas the 5′UTR, 3′UTR, and the coding sequence of LDLR mRNA are all implicated in the action of phorbol 12-myristate 13-acetate. By performing UV cross-linking and SDS-PAGE, we identify 2 cytoplasmic proteins of 52 and 42 kDa that specifically bind to the LDLR 3′UTR in BBR-inducible and ERK-dependent manners. Conclusions— These new findings demonstrate that the BBR-induced stabilization of LDLR mRNA is mediated by the ERK signaling pathway through interactions of cis -regulatory sequences of 3′UTR and mRNA binding proteins that are downstream effectors of this signaling cascade.

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Crossref · 10.1161/01.atv.0000181761.16341.2b

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  • LDLR mRNA becomes stabilized two- to three-fold in response to extracellular stimuli including PMA, bile acids, berberine, and TCN.

    “LDLR mRNA has a half-life of approximately 1–2 h in HepG2 cells and it becomes stabilized two- to three-fold in response to extracellular stimuli, including phorbol 12-myristate 13-acetate (PMA) [7], bile acids [8,9], berberine (BBR) [5,10,11], and triciribine (TCN) [12].”

    From Triciribine Engages ZFP36L1 and HuR to Stabilize LDLR mRNA (2020) · cites this paper as [10]

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Research works printed but not linked: 28

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Metadata

Authors
Abidi, P., Zhou, Y., Jiang, J.-D., & Liu, J.
Affiliations
From the VA Palo Alto Health Care System (P.A., Y.Z., J.L.), Palo Alto, Calif; and Institute of Medicinal Biotechnology (J.-D.J.), Chinese Academy of Medical Sciences, Beijing, China.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-10
Volume
25
Issue
10
Pages
2170-2176
ISSN
  • 1079-5642
  • 1524-4636
DOI
10.1161/01.atv.0000181761.16341.2b
Cited by
152
References
2
Language
en

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