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Cited by 54

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3′ untranslated region

Wilson, G.M., Vasa, M.Z., Deeley, R.G.·1998·Journal of Lipid Research
DOI 10.1016/s0022-2275(20)33870-0
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Crossref · 10.1016/s0022-2275(20)33870-0

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  • LDLR 3′UTR contains cis-regulating elements that modulate the rate of LDLR mRNA degradation through interaction with trans-regulatory RNA binding proteins.

    “Embedded within the LDLR 3′UTR are several cis-regulating elements that modulate the rate of LDLR mRNA degradation through their interaction with trans-regulatory RNA binding proteins8,13.”

    From Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA (2018) · cites this paper as [8]

    The Results and Discussion show that several cis-acting elements in the LDLR 3′UTR affect mRNA turnover in HepG2 cells. The Discussion describes interactions between AU-rich elements and RNA-binding proteins as a general mechanism, but does not establish that the LDLR elements regulate degradation through such interactions. The indexed passages do not provide section-specific page numbers. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • LDLR mRNA contains three adenine-uridine rich elements (AREs) within the 3'UTR.

    “LDLR mRNA contains three adenine-uridine rich elements (AREs) within the 3’UTR60,61.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [60]

  • LDLR gene expression is subject to posttranscriptional regulation at the point of mRNA stability.

    “In addition to transcriptional regulation, LDLR gene expression is subject to posttranscriptional regulation at the point of mRNA stability”

    From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [8]

  • Post-transcriptional regulation of LDLR is mainly achieved through modulation of its mRNA stability.

    “The post-transcriptional regulation of LDLR is mainly achieved through modulation of its mRNA stability8–11.”

    From Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA (2018) · cites this paper as [8]

  • The LDLR mRNA 3′ UTR harbors four AU-rich elements (AREs) that are docking sites for cytoplasmic ARE-binding proteins.

    “This region harbors four adenylate-uridylate (AU)-rich elements (AREs)”

    From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [8]

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Citations

Cites

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Research works printed but not linked: 31

  1. Goldstein, 1984, Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol, J. Lipid Res., 25, 1450, 10.1016/S0022-2275(20)34418-7 · DOI
  2. Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311 · DOI · Paper page
  3. Dietschy, 1970, Regulation of cholesterol metabolism (part 3), N. Engl. J. Med., 282, 1241, 10.1056/NEJM197005282822206 · DOI
  4. Goldstein, 1977, The low-density lipoprotein pathway and its relation to atherosclerosis, Annu. Rev. Biochem., 46, 897, 10.1146/annurev.bi.46.070177.004341 · DOI · Paper page
  5. Hobbs, 1990, The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein, Annu. Rev. Genet., 24, 133, 10.1146/annurev.ge.24.120190.001025 · DOI · Paper page
  6. Bilheimer, 1984, Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia, N. Engl. J. Med., 311, 1658, 10.1056/NEJM198412273112603 · DOI
  7. Grossman, 1994, Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia, Nature Genet., 6, 335, 10.1038/ng0494-335 · DOI
  8. Javitt, 1990, HepG2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids, FASEB J., 4, 161, 10.1096/fasebj.4.2.2153592 · DOI
  9. Knowles, 1980, Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen, Science, 209, 497, 10.1126/science.6248960 · DOI
  10. Kraft, 1992, Regulation of LDL receptor, apoB, and apoE protein and mRNA in HepG2 cells, DNA Cell Biol., 11, 291, 10.1089/dna.1992.11.291 · DOI
  11. Tam, 1991, Differences between the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasts reside primarily at the translational and post-translational levels, J. Biol. Chem., 266, 16764, 10.1016/S0021-9258(18)55366-7 · DOI
  12. Illingworth, 1984, Regulation of low-density lipoprotein receptors in the human hepatoma cell line HepG2, Exp. Cell Res., 155, 518, 10.1016/0014-4827(84)90211-8 · DOI
  13. Kamps, 1992, Complete down-regulation of low-density-lipoprotein-receptor activity in the human hepatoma cell line HepG2 by β-migrating very-low-density-lipoprotein and non-lipoprotein cholesterol, Eur. J. Biochem., 206, 973, 10.1111/j.1432-1033.1992.tb17008.x · DOI
  14. Auwerx, 1989, Involvement of second messengers in regulation of the low-density lipoprotein receptor gene, Mol. Cell. Biol., 9, 2298
  15. Auwerx, 1989, Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein, Proc. Natl. Acad. Sci. USA, 86, 1133, 10.1073/pnas.86.4.1133 · DOI
  16. Kamps, 1993, Regulation of low-density-lipoprotein receptors in the human hepatoma cell line HepG2, Eur. J. Biochem., 213, 989, 10.1111/j.1432-1033.1993.tb17845.x · DOI
  17. Iyengar, 1996, Gating by cyclic AMP: expanded role for an old signalling pathway, Science, 271, 461, 10.1126/science.271.5248.461 · DOI
  18. Clapham, 1995, Calcium signalling, Cell, 80, 259, 10.1016/0092-8674(95)90408-5 · DOI
  19. Haller, 1994, Role of protein kinase C in intracellular signalling, Ann. NY Acad. Sci., 733, 313, 10.1111/j.1749-6632.1994.tb17281.x · DOI
  20. Wilson, 1997, Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models, J. Lipid Res., 38, 437, 10.1016/S0022-2275(20)37252-7 · DOI · Paper page
  21. Wilson, 1995, An episomal expression vector system for monitoring sequence-specific effects on mRNA stability in human cell lines, Plasmid, 33, 198, 10.1006/plas.1995.1021 · DOI
  22. Feinberg, 1984, A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem., 137, 266, 10.1016/0003-2697(84)90381-6 · DOI
  23. Zambetti, 1990, Differential association of membrane-bound and non-membrane bound polysomes with the cytoskeleton, Exp. Cell Res., 191, 246, 10.1016/0014-4827(90)90011-X · DOI
  24. Zubiaga, 1995, The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation, Mol. Cell. Biol., 15, 2219, 10.1128/MCB.15.4.2219 · DOI
  25. Ross, 1995, mRNA stability in mammalian cells, Microbiol. Rev., 59, 423, 10.1128/mr.59.3.423-450.1995 · DOI · Paper page
  26. DeMaria, 1996, AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation, J. Biol. Chem., 271, 12179, 10.1074/jbc.271.21.12179 · DOI
  27. Chen, 1994, Defining a novel ribonucleotide reductase R1 mRNA cis-element that binds to a unique cytoplasmic trans-acting protein, Nucleic Acids Res., 22, 4796, 10.1093/nar/22.22.4796 · DOI
  28. Amara, 1996, Defining a novel cis-element in the 3′-untranslated region of mammalian ribonucleotide reductase component R2 mRNA. cis–trans-interactions and message stability, J. Biol. Chem., 271, 20126, 10.1074/jbc.271.33.20126 · DOI
  29. Chen, 1993, Mammalian ribonucleotide reductase R1 mRNA stability under normal and phorbol ester stimulating conditions: involvement of a cis–trans interaction at the 3′ untranslated region, EMBO J., 12, 3977, 10.1002/j.1460-2075.1993.tb06075.x · DOI
  30. Ross, 1997, Characterization of a β-actin mRNA zipcode-binding protein, Mol. Cell. Biol., 17, 2158, 10.1128/MCB.17.4.2158 · DOI
  31. Hesketh, 1996, Sorting of messenger RNAs in the cytoplasm: mRNA localization and the cytoskeleton, Exp. Cell Res., 225, 219, 10.1006/excr.1996.0172 · DOI

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Metadata

Authors
Wilson, G. M., Vasa, M. Z., & Deeley, R. G.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1998-05
Volume
39
Issue
5
Pages
1025-1032
ISSN
0022-2275
DOI
10.1016/s0022-2275(20)33870-0
Cited by
54
References
2
Language
en
Licence

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