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The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Abstract
The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
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“Circulating levels of decorin are increased in response to exercise in humans (46), whereas exercise training reduces the levels of myostatin within muscles and blood (47, 48).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
In the citing paper
“Decorin has been identified as a myokine that is regulated by exercise and acts as an antagonist to myostatin (46).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013
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Hjorth, M., Egan, C. L., Telles, G. D., Pál, M., Gallego‐Ortega, D., Fuller, O. K., McLennan, E. D., Gillis, R. D., Oh, T. G., Muscat, G. E. O., et al. (2024) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.100991 · Cited by 13
“Decorin peaked our interest because, firstly, it has been reported to increase in human serum following exercise 22 and, secondly, because it has been suggested to have a protective effect against breast cancer in preclinical models.”
InfluentialMuscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle
Gudiksen, A., Bertholdt, L., Vingborg, M. B., Hansen, H. W., Ringholm, S., & Pilegaard, H. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00291.2016 · Cited by 12
“While increased levels of circulating fatty acids have been demonstrated to contribute to the regulation of PDK4 in rodent skeletal muscle with fasting (38), hormones and muscle-derived factors may play a role as well (10, 15, 33, 34).”
BackgroundHekmatikar, A. H. A., Nelson, A. R., & Petersen, A. C. (2023) · BMC Cancer · doi:10.1186/s12885-023-11391-3 · Cited by 13
The Role of Myokines in Liver Diseases
Nishikawa, H., Kim, S. K., & Asai, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031043 · Cited by 12
Exercise, Exerkines, and Sarcopenia
Chung, H. S., & Choi, K. M. (2026) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0972 · Cited by 12
Ishiuchi-Sato, Y., & Nedachi, T. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0275 · Cited by 11
“Endocrine Journal Advance Publication Endocrine Journal Advance Publication myokine [36] and has the capacity to bind collagen, which is believed to regulate collagen fibrillogenesis and the final diameter of fibrils [37].”
BackgroundWhat Muscle Signals Mediate the Beneficial Effects of Exercise on Cognition?
Benarroch, E. E. (2022) · Neurology · doi:10.1212/wnl.0000000000201049 · Cited by 12
“For example, myostatin, a member of the transforming growth factor β family, negatively regulates myogenesis,(43) whereas decorin released during exercise acts as an antagonist to myostatin.(44) Interleukin-6 (IL-6) is also released by muscle during exercise; it promotes myogenesis through the mechanistic target of ra…”
BackgroundGorgey, A. S., Khalil, R. E., Alrubaye, M. W., Gill, R. S., Rivers, J. F., Goetz, L. L., Cifu, D. X., Castillo, T. A., Caruso, D. M., Lavis, T. D., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-064748 · Cited by 11
Nio, Y., Okawara, M., Okuda, S., Matsuo, T., & Furuyama, N. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00123 · Cited by 11
Liu, Y., Xu, C., Asiamah, C. A., Ye, R., Pan, Y., Lu, L., Zhao, Z., Jiang, P., & Su, Y. (2021) · Gene · doi:10.1016/j.gene.2021.145884 · Cited by 10
Sabouri, M., Taghibeikzadehbadr, P., Shabkhiz, F., Izanloo, Z., & Shaghaghi, F. A. (2022) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-021-09613-x · Cited by 12
Myokines and Biomarkers of Frailty in Older Inpatients with Undernutrition: A Prospective Study
Liu, H., Li, W., Zhu, M., Wen, X., Jin, J., Wang, H., Lv, D., Zhao, S., Wu, X., & Jiao, J. (2024) · The Journal of Frailty & Aging · doi:10.14283/jfa.2024.9 · Cited by 11
“Additionally, even though previous research suggested that plasma DCN is increased after acute and chronic exercise (49), Willoughby et. al conducted nutritional intervention combined with exercise in older women whereas no significant difference in the serum DCN levels compared to the control…”
Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.
Das, S., Preethi, B., Kushwaha, S., & Shrivastava, R. (2024) · PubMed · doi:10.14670/hh-18-730 · Cited by 13
Nasiri, E., Harsini, A. G., Arabi, F., Samadi, A., & Kamak, Z. R. (2021) · Sport Sciences for Health · doi:10.1007/s11332-021-00846-4 · Cited by 9
Sawicka, A. K., Jaworska, J., Brzeska, B., Sabisz, A., Samborowska, E., Radkiewicz, M., Szurowska, E., Winklewski, P. J., Szarmach, A., & Olek, R. A. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1848-y · Cited by 9
“plasma decorin at the end of the session, although 120 min after the end of exercise it returns to baseline level (6) and resting plasma decorin level is not affected by 5 weeks exercise intervention (59).”
BackgroundNitahara‐Kasahara, Y., Posadas-Herrera, G., Mizumoto, S., Nakamura-Takahashi, A., Inoue, Y., Inoue, T., Nomura, Y., Takeda, S., Yamada, S., Kosho, T., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.695021 · Cited by 9
Berciano, M. T., Gatius, A., Puente-Bedia, A., Rufino-Gómez, A., Tarabal, O., Rodríguez-Rey, J. C., Calderó, J., Lafarga, M., & Tapia, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212415 · Cited by 8
“Later, we investigated the expression of Dcn , which encodes decorin, a small leucine-rich proteoglycan that prevents muscle atrophy by inhibiting the action of myostatin [52] and negatively regulating A trogin-1 and MuRF1 expression [24,53,54].”
Liu, X., Zhang, N., Sung, B., & Wang, B. (2022) · Physiological Research · doi:10.33549/physiolres.934833 · Cited by 8
The decorin and myostatin response to acute whole body vibration: impact of adiposity, sex, and race
Broniec, M. N., Norland, K., Thomas, J., Wang, X., & Harris, R. A. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01630-3 · Cited by 9
Effect of myokines on bone tissue metabolism: a systematic review
Jaśkiewicz, Ł., Romaszko-Wojtowicz, A. M., Chmielewski, G., Kuna, J., & Krajewska–Włodarczyk, M. (2025) · Bone · doi:10.1016/j.bone.2025.117654 · Cited by 11
Health benefits of physical activity: What role does skeletal muscle-organ crosstalk play?
Powers, S. K., Goldstein, E. R., Lategan-Potgieter, R., Schrager, M. A., Skelton, M., & Demirel, H. A. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.02.010 · Cited by 7
“143,144 Second, regular exercise decreases the levels of myostatin both in muscle and blood.”
Takei, K., Kijima, T., Okubo, N., Kurashina, R., Kokubun, H., Uematsu, T., Betsunoh, H., Yashi, M., & Kamai, T. (2023) · Cancers · doi:10.3390/cancers15235591 · Cited by 7
“Another myokine that may have anti-cancer potential is decorin, ubiquitously expressed in connective tissues [23].”
BackgroundTHE ROLE OF MYOKINES INTERSTITIAL INTERACTION AND REGULATION OF METABOLISM: A REVIEW OF LITERATURE
Тамерланович, Ц. Т., White, Z. E., & Rozhinskaya, L. Y. (2016) · Osteoporosis and Bone Diseases · doi:10.14341/osteo2016128-34 · Cited by 7
Skeletal Muscle as Endocrine Organ
Ma, M., Zhang, Z., Hai, B., & Zhang, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_22 · Cited by 9
Barros, D. G. M., Silva‐Fernandes, A., Martins, S., Guerreiro, S. G., Magalhães, J., Carvalho, J., & Marques, E. A. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.105271 · Cited by 8
Myokine Secretion Dynamics and Their Role in Critically Ill Patients: A Scoping Review
Jalil, Y., Damiani, L. F., García-Valdés, P., Basoalto, R., Gallastegui, J., & Gutiérrez-Arias, R. E. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14092892 · Cited by 6
“In this respect, it has been suggested that decorin could act as a modulator of myostatin activity by competitively binding to it, potentially preventing myostatin from exerting its inhibitory effects on muscle growth [19,51].”
Yoshioka, K., Itô, A., Horie, M., Ikeda, K., Kataoka, S., Sato, K., Yoshigai, T., Sakurai, H., Hotta, A., Kawabe, Y., et al. (2021) · Cells · doi:10.3390/cells10102556 · Cited by 6
“Muscle contraction is known to trigger the expression of some myokines, such as decorin [23].”
BackgroundPaltsyn, A. A. (2020) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2020.01.135-141 · Cited by 6
Myokines in obese adolescents with aerobic exercise
Kasyanova, Y. V., Vasyukova, O. V., Okorokov, P. L., Zuraeva, Z. T., & Bezlepkina, O. B. (2022) · Problems of Endocrinology · doi:10.14341/probl13138 · Cited by 6
Olek, R. A., Samborowska, E., Wiśniewski, P., Wojtkiewicz, P., Wochna, K., & Zieliński, J. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00752-1 · Cited by 6
“In addition, increased muscle decorin expression, correlates with improvement in leg press performance [36].”
BackgroundMyokines: A central point in managing redox homeostasis and quality of life
Rathor, R., & Suryakumar, G. (2024) · BioFactors · doi:10.1002/biof.2054 · Cited by 6
“42,43 Jang et al., 44 reported significantly increase in follistatin concentration after 8 weeks pulley-training.”
Shirvani, H., Shamsoddini, A., Bazgir, B., McAinch, A. J., Najjari, A., & Arabzadeh, E. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11072-3 · Cited by 5
“Decorin binds myostatin, an inhibitor of muscle growth, thereby promoting pro-myogenic factors like Mighty and follistatin [63].”
Luo, X., Zhang, M., Chen, L.-L., Wang, R., Lian, J., Yang, Z., Iozzo, R. V., Wang, J., Zhang, Y., & Bi, X. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70144 · Cited by 6
“Decorin is widely distributed in mesenchymal tissues and expressed and secreted in a variety of connective tissues [21, 22].”
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · eLife · doi:10.7554/elife.96535 · Cited by 13
“…al., 2018 ), myostatin ( Hjorth et al., 2016 ; McPherron et al., 1997 ), METRNL ( Rao et al., 2014 ), CSF1 ( Pourteymour et al., 2017 ), decorin ( Kanzleiter et al., 2014 ), SFRP4 Lee et al., 2019 , fetuin-A ( Lee et al., 2017 ; Malin et al., 2014 ), and ANGPTL4 ( Catoire et al., 2014 ; Norheim…”
Moqaddam, M. A., Nemati, M., Dara, M. M., Hoteit, M., Sadek, Z., Ramezani, A., Rand, M. K., Daloii, A. A., Pashaei, Z., Almaqhawi, A., et al. (2024) · Nutrients · doi:10.3390/nu16172857 · Cited by 5
“Additionally, this 12-week exercise training supplemented with AST resulted in divergent findings in adipo-myokiness such that the plasma levels of DNC and FST were elevated while three members of the TGF-β family including activin A, MST, and TGF-β 1 were diminished.”
MethodCharacteristics of Skeletal Muscle as a Secretory Organ
Aoi, W. (2017) · Springer eBooks · doi:10.1007/978-981-10-3292-9_9 · Cited by 5
Mannaperuma, D., Stratton, D., Lange, S., & Inal, J. M. (2025) · Biology · doi:10.3390/biology14111578 · Cited by 5
“Furthermore, decorin has been reported to be an exercise-regulated myokine which is secreted in response to muscle contractions [170] and associated with major roles in muscle cell differentiation, wound healing, muscular development and regulation of inflammation [156].”
Li, A., Sun, R., Wu, Y., Zhang, Q., Mao, R., Sun, X.-D., Wang, L., & Ren, X.-Y. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2026.1768179 · Cited by 5
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential
Aslam, M. A., Lee, J., Bowen, T. S., & Huh, J. Y. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01624-x · Cited by 7
“Decorin is released from skeletal muscles in response to acute resistance exercise in humans, and its expression also increases after chronic training in both mice and humans (Kanzleiter et al. 2014).”
Myokines: A potential key factor in development, treatment, and biomarker of sarcopenia
Aoi, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00006-5 · Cited by 4
Blottner, D., & Michele Salanova, A. (2014) · SpringerBriefs in space life sciences · doi:10.1007/978-3-319-12298-4_3 · Cited by 4
Hayashi, S., & Yonekura, S. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.10.018 · Cited by 4
Pedersen, B. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_31 · Cited by 4
Egan, C. L., Doncheva, A. I., Pál, M., Fox, S. L., Dalen, K. T., Whitham, M., Febbraio, M. A., & Hjorth, M. (2025) · Physiological Reports · doi:10.14814/phy2.70424 · Cited by 3
“This may indicate a role of decorin as an exercise-induced myokine (Bekki et al., 2018; Kanzleiter et al., 2014; Langlois et al., 2025).”
Mănescu, D. C., Plastoi, C. D., Pîrvan, A., Dîrnu, R., Floroiu, E. A., & Popescu, A. (2026) · Cells · doi:10.3390/cells15141236 · Cited by 5
“Resistance exercise primarily stresses mechanical and anabolic pathways, including mTORC1, extracellular-matrix remodeling and myostatin–follistatin– decorin balance [23,26,27,54].”
Tymochko-Voloshyn, R. I., Hashchyshyn, V., Параняк, Н., Boretsky, V. Y., Решетило, С., & Boretsky, Y. (2023) · Visnyk of Lviv University Biological series · doi:10.30970/vlubs.2023.88.01 · Cited by 4
Kirk, E. A., Castellani, C. A., Doherty, T. J., Rice, C. L., & Singh, S. M. (2022) · Physiological Genomics · doi:10.1152/physiolgenomics.00146.2021 · Cited by 3
Lima, W. P. (2017) · Revista Brasileira de Fisiologia do Exercício · doi:10.33233/rbfe.v16i2.972 · Cited by 3
Arabzadeh, E., Gil-kalayeh, Z. G., Gholami, M., Natanzi, H. A., & Ebrahimi, S. (2023) · Sport Sciences for Health · doi:10.1007/s11332-022-01035-7 · Cited by 3
“1 3 showed an increase in muscle Decorin expression following resistance exercise training [19].”
BackgroundInfluentialErythrocytes as a Source of Exerkines
Misiti, F., Falese, L., Iannaccone, A., & Diotaiuti, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199665 · Cited by 2
“In addition, a range of other exerkines are recognized, including IL7 [8], 12,13-diHOME [9], myonectin [10], myostatin [11], METRNL, CSF1, decorin [12–15], SFRP4 [5], fetuin-A [16], and ANGPTL4 [17], among many others [5].”
Effect of an acute bout of endurance eccentric exercise on exerkines production in healthy males
Carlet, T., Rannou, F., Pereira, B., Kellawan, J. M., Pereira, H. M., Ennequin, G., & Garnier, Y. M. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-06015-6 · Cited by 2
Babaeinejad, M., Matinhomaee, H., & Fatolahi, H. (2023) · Journal of Shahrekord University of Medical Sciences · doi:10.34172/jsums.802 · Cited by 2
“Kanzleiter et al found that DCN plasma concentration is increased in humans who perform acute resistance training (13).”
BackgroundShaker, H., Sayed, A., Mahran, S., Abbas, M., Khail, K., & Yousef, K. (2023) · International Japan-Africa Conference on Electronics, Communications, and Computations (JAC-ECC) · doi:10.1109/jac-ecc61002.2023.10479661 · Cited by 2
González‐Reimers, E., Quintero‐Platt, G., González‐Arnay, E., Martín‐González, C., Romero-Acevedo, L., & Santolaria-Fernández, F. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00030-0 · Cited by 2
Wu, D., Su, J., Wang, P., Zhai, B., Zhao, C., Li, W., Chen, C., Guan, J., Cao, Z., Song, N., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118316 · Cited by 2
Health benefits of aerobic exercise: known mechanisms and research potential
Begrambekova, Y. L., & Orlova, Y. A. (2021) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2021-2878 · Cited by 3
Hanif, M. A., Hossen, S., Lee, W. K., & Kho, K. H. (2022) · Genes · doi:10.3390/genes14010002 · Cited by 1
“Short-term starvation does not interfere with normal muscle physiology, including normal production of myokines such as decorin, that are released during muscle contraction [54].”
Myokine Expression in Cancer Cachexia
Manole, E., Ceafalan, L. C., Gaina, G. F., Mosoia, O., & Hinescu, M. E. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2023_138 · Cited by 1
Mondal, S., Srivastava, S., Srivastava, S., Rathor, R., & Suryakumar, G. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01100-y · Cited by 1
“It may play a role in muscle hypertrophy, the increase in muscle size, by modulating myostatin and TGF-β signaling [ 57].”
Niazi, S., Rajabi, H., & Amani-Shalamzari, S. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01501-y · Cited by 1
“Another myokine, decorin, is involved in the growth of muscle mass [13]; it could trap myostatin and modulate its activity toward myogenic cells [14].”
Razi, O., Shafei, A., Abdi, M., Saeidi, B., Farzanegi, P., Zamani, N., ALNasser, M. N., Hejazi, K., Almaqhawi, A., Saeidi, A., et al. (2026) · Nutrients · doi:10.3390/nu18030509 · Cited by 1
“The concurrent reduction in myostatin levels within the training groups aligns with prior research suggesting decorin’s ability to interfere with myostatin signaling, possibly through the upregulation of the Mighty gene [37].”
Jak mięśnie komunikują się z innymi narządami i co z tego wynika?
Ziemann, E. (2021) · Kosmos · doi:10.36921/kos.2020_2707 · Cited by 1
Plasma Activin A and Decorin in Exercised Purebred Arabian Horses – Preliminary Study
Kędzierski, W., Kowalik, S., Mojsym, W., Janczarek, I., & Tkaczyk, E. (2021) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2021.103638 · Cited by 1
Pedersen, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_31-1 · Cited by 1
Vosadi, E., Gholami, F., & Mortazavi, E. (2021) · journal of ilam university of medical sciences · doi:10.52547/sjimu.29.2.86 · Cited by 1
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · medRxiv · doi:10.1101/2024.02.10.24302626 · Cited by 1
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · eLife · doi:10.7554/elife.96535.1 · Cited by 1
Targeting Inflammation in Type 2 Diabetes: The Emerging Role of Decorin
Sharmine, S., & Ghila, L. (2025) · Acta Physiologica · doi:10.1111/apha.70049 · Cited by 1
Nutritional impact on molecular and physiological adaptations to exercise : nutrition matters
Knuiman, P. (2019) · doi:10.18174/479016
“Primers for all genes, obtained from the Harvard PrimerBank [27], are”
MethodEckel, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809518-8.00006-4
Baghy, K., Reszegi, A., Horváth, Z., & Kovalszky, I. (2022) · Biology of extracellular matrix · doi:10.1007/978-3-030-99708-3_2
Olek, R. A., Samborowska, E., Wiśniewski, P., Wojtkiewicz, P., Wochna, K., & Zieliński, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1967863/v1
Olek, R. A., Samborowska, E., Wiśniewski, P., Wojtkiewicz, P., Wochna, K., & Zieliński, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1967863/v2
Muskulatur: „peripheres mechanisch- und Signalstoff-gestütztes Zentrum der Gesundheit“
Laube, W. (2023) · Springer eBooks · doi:10.1007/978-3-662-67753-7_8
Miyokin / Sitokinlerin Kas Hipertrofisindeki Rolü
DÜNDAR, S. T., & VAROL, S. R. (2023) · doi:10.59287/spbgy.949
Daliran, M., Moradi, L., & Azarbayjani, M. A. (2022) · Journal of Sports Physiology and Athletic Conditioning · doi:10.61186/jspac.38834.2.5.25
“Kanzleiter et al. (2014) showed that muscular transcription of Decorin increased after one bout exercise and it associated with increased plasma levels of decorin (12).”
BackgroundThe effects of exercise on post-burn muscle wasting
Dombrecht, D. (2024) · doi:10.63028/10067/2031330151162165141
Lee-Ødegård, S., Hjorth, M., Olsen, T., et al. (2024) · eLife · doi:10.7554/elife.96535.2.sa1
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · eLife · doi:10.7554/elife.96535.2
Lee-Ødegård, S., Hjorth, M., Olsen, T., et al. (2024) · eLife · doi:10.7554/elife.96535.2.sa2
Lee-Ødegård, S., Hjorth, M., Olsén, T., Moen, G.-H., Daubney, E. R., Evans, D. M., Hevener, A. L., Lusis, A. J., Zhou, M., Seldin, M. M., et al. (2024) · eLife · doi:10.7554/elife.96535.2.sa0
The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease
Chang, J. S. (2024) · Exercise Science · doi:10.15857/ksep.2024.00472
Comparison of Muscle Damage Markers and Myokines between Adult and Middle-Aged Marathon Runners
Zocoler, C. A. S., Sierra, A., Lima, G. H. O., Galán, B. S. M., Barbeiro, H. V., de Souza, H. P., & Cury‐Boaventura, M. F. (2025) · OBM Geriatrics · doi:10.21926/obm.geriatr.2501301
Body Kines and Organ Crosstalks: A Mini Review
Elnaggar, N. K., & Elnaggar, M. (2025) · International Journal of Diabetes and Endocrinology · doi:10.11648/j.ijde.20251002.13
Which training model has the best effect on adipo-myokines in men with obesity?Preprint
Razi, O., Hamdi, S., Rahim, H. A., Abednatanzi, H., Najafabadi, M. K., Hejazi, K., Nahand, M. S., Daloii, A. A., Moghadam, A. G., Mollabashi, S. S., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6297875/v1
Bernard, D., Sultan, A., & Bouzakri, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178182
“Its plasma concentration is up regulated after a resistance exercise bout in humans and is described to be implicated in muscle hypertrophy [143].”
Increased Skeletal Muscle Oxidative Capacity Augments the Myokine Response to Whole Body Vibration
Broniec, M. N., Norland, K., Looney, J. C., Crandall, R. H., Thomas, J., Wang, X., & Harris, R. A. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003854 · Cited by 1
Myokine-Mediated Muscle-Kidney Crosstalk
Formenti, P., & Umbrello, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-01024-7_14
Systemic and local decorin levels mirror the clinical course of pancreatic cancer
Svensson, M., Lehn, S., Jacobsen, H., Hau, S. O., Jönsson, G. B., Pietras, K., & Jirström, K. (2025) · The Journal of Pathology Clinical Research · doi:10.1002/2056-4538.70066
“As DCN binds to and directly inhibits myostatin [29], a potent inhibitor of muscle growth [30], it has been suggested as a potential target for maintaining the muscle mass in cachexia [31].”
Olek, R., Samborowska, E., Wisniewski, P., Wojtkiewicz, P., Wochna, K., & Zieliński, J. (2023) · Figshare · doi:10.6084/m9.figshare.23826949
Mahdabi, E. R., Esmailizadeh, A., Mehrgardi, A. A., & Fozi, M. A. (2021) · Figshare · doi:10.6084/m9.figshare.16599608
Bergsport und Stütz- und Bewegungsapparat
Burtscher, M. (2025) · Springer eBooks · doi:10.1007/978-3-662-70316-8_7
Can Non-Conventional Blood Biomarkers Improve Running Performance Prediction? A Proof of Concept
Dvorski, M., Rakovac, M., Kelava, T., Kovačić, N., Flegar, D., Aničić, S., Krešić, I., Ćulibrk, L., Koražija, F., Dimnjaković, D., et al. (2026) · Life · doi:10.3390/life16020320
Burn injury dysregulates protein signaling in type 1 and type 2 muscles in rats
Dombrecht, D., Daele, U. V., Asbroeck, B. V., Schieffelers, D. R., Guns, P., & van Breda, E. (2026) · Burns · doi:10.1016/j.burns.2026.107948
Xie, L., Sasmita, B. R., Zhao, Y., Chen, J., Li, Y., Luo, S., & Huang, B. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1762912
Preventing Metabolic Syndrome in Adolescents Through Exercise
Calcaterra, V., Vandoni, M., Rossi, V., Gatti, A., & Zuccotti, G. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-7000-3_19
Mallard, J. (2022) · theses.fr (ABES) · doi:10.70675/f8b2c96bzc4cdz4249z8e59z5f87c7ca2462
Skeletal muscle as an endocrine and paracrine organ in breast cancer biology: a narrative review
Carpenter, D. J., Peluso, C., Xiao, K., Rosenberg, J., Lee, P. L., & Champ, C. E. (2026) · Discover Oncology · doi:10.1007/s12672-026-05027-8
Metadata
- Authors
- Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., & Eckardt, K.
- Affiliations
- German Center for Diabetes Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Norwegian School of Sport Sciences (NO)
- Charles University (CZ)
- University of Oslo (NO)
- Corresponding author
- Eckardt, Kristin
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 450
- Issue
- 2
- Pages
- 1089-1094
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2050986782
- Cited by
- 209
- References
- 32
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 24 · 2023: 16 · 2022: 35 · 2021: 22 · 2020: 16 · 2019: 12 · 2018: 10 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Deutsche Forschungsgemeinschaft (EC 440/1-1)
- Leibniz-Gemeinschaft (SAW-FBN-2013-3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- decorin, myokines, muscle contraction, muscle hypertrophy, resistance training, skeletal muscle growth, myostatin, MyoD, follistatin, atrogin-1, MuRF1, ubiquitin ligase, muscle atrophy, myotubes, exercise training
- MeSH terms
- Adolescent, Adult, Animals, Cells, Cultured, Female, Humans, Male, Muscle Contraction, Physical Conditioning, Animal, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Mice, Decorin
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