The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Abstract
The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Circulating levels of decorin are increased in response to exercise in humans (46), whereas exercise training reduces the levels of myostatin within muscles and blood (47, 48).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
In the citing paper
“Decorin has been identified as a myokine that is regulated by exercise and acts as an antagonist to myostatin (46).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–209 of 209
Key hormones for the control of muscle mass: Myokines
Gu, H., Albrecht, E., Deng, Z., & Maak, S. (2026) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2026.102115
Cornish, S. M., & Peralta-Huertas, J. (2026) · Biomolecules · doi:10.3390/biom16060850 · Cited by 1
“Rising plasma levels in response to resistance exercise; increases muscle hypertrophy [47].”
Hernández‐Camacho, J. D., & Saclier, M. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70212
“(Wohlgemuth et al. 2011) (Picard et al. 2013) (Iversen et al. 2011) (Broskey et al. 2014) (Kanzleiter et al. 2014) (Kim et al. 2015) (Seo et al. 2021) ( Older male and female individuals ( ≥ 65 years) diagnosed with sarcopenia.”
Skeletal Muscle Decorin, Apelin and TRIM72 Gene Expression in Relation to Insulin Sensitivity
Szutko, D., & Straczkowski, M. (2026) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2937-4910
“formal analysis, investigation, methodology, visualization, writing – original draft,”
Li, Z., Lin, C., Tang, L., Xu, Y., Liang, J., Pan, D., Huang, Z., Xie, X., Wang, Y., Qin, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177527
“Decorin can be released by contracting myotubes and is increased after acute resistance exercise, participating in skeletal muscle hypertrophy and remodeling [73].”
Corrêa, H. D. L., dos Santos, R. L., Neto, I. V. D. S., Neves, R. V. P., Baracho, T. A. F., Martins, T. O., Barbosa, J. M. D. S., de Araújo, T. B., de Sousa, L. L., Salomão, R., et al. (2026) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-026-00399-3
The Myokine Landscape: Sources, Signaling, and Context-Dependent Actions
Casadevall, C., Ramírez-Sarmiento, A., Camps-Ubach, R., Barreiro, E., Orozco‐Levi, M., & Gea, J. (2026) · Cells · doi:10.3390/cells15181682
“Decorin may therefore contribute to exercise-induced hypertrophy by shifting the local balance away from myostatin-mediated growth inhibition [83,84].”
Lee, E. J., Ahmad, K., Shaikh, S., Lim, J. H., Ahmad, S. S., Seo, M., & Choi, I. (2026) · Food Science of Animal Resources · doi:10.1007/s44463-026-00108-2
“Overexpression of decorin upregulates pro-myogenic genes (Mighty, Myod1, and follistatin) while downregulating muscle atrophy markers (Atrogin1 and MuRF1) (Kanzleiter et al., 2014 ).”
Exercise against cancer: recent advances and open questions
Plaza‐Florido, A., Rundqvist, H., Galvao, D. A., Pinós, T., Ruiz‐Casado, A., Fiuza‐Luces, C., Schadler, K., Courneya, K. S., & Lucı́a, A. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.10.003
Metadata
- Authors
- Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., & Eckardt, K.
- Affiliations
- German Center for Diabetes Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Norwegian School of Sport Sciences (NO)
- Charles University (CZ)
- University of Oslo (NO)
- Corresponding author
- Eckardt, Kristin
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 450
- Issue
- 2
- Pages
- 1089-1094
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2050986782
- Cited by
- 209
- References
- 32
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 24 · 2023: 16 · 2022: 35 · 2021: 22 · 2020: 16 · 2019: 12 · 2018: 10 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Deutsche Forschungsgemeinschaft (EC 440/1-1)
- Leibniz-Gemeinschaft (SAW-FBN-2013-3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- decorin, myokines, muscle contraction, muscle hypertrophy, resistance training, skeletal muscle growth, myostatin, MyoD, follistatin, atrogin-1, MuRF1, ubiquitin ligase, muscle atrophy, myotubes, exercise training
- MeSH terms
- Adolescent, Adult, Animals, Cells, Cultured, Female, Humans, Male, Muscle Contraction, Physical Conditioning, Animal, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Mice, Decorin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
