The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Abstract
The health-promoting effects of regular exercise are well known, and myokines may mediate some of these effects. The small leucine-rich proteoglycan decorin has been described as a myokine for some time. However, its regulation and impact on skeletal muscle has not been investigated in detail. In this study, we report decorin to be differentially expressed and released in response to muscle contraction using different approaches. Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans. Moreover, decorin expression in skeletal muscle is increased in humans and mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin in the regulation of skeletal muscle growth. In vivo overexpression of decorin in murine skeletal muscle promoted expression of the pro-myogenic factor Mighty, which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific ubiquitin ligases atrogin1 and MuRF1, which are involved in atrophic pathways, were reduced by decorin overexpression. In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
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“Circulating levels of decorin are increased in response to exercise in humans (46), whereas exercise training reduces the levels of myostatin within muscles and blood (47, 48).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
In the citing paper
“Decorin has been identified as a myokine that is regulated by exercise and acts as an antagonist to myostatin (46).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [46]
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“Circulating levels of decorin are increased in response to exercise in humans (46), whereas exercise training reduces the levels of myostatin within muscles and blood (47, 48).”
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Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419
“Decorin seems to act in a paracrine manner by directly binding to and thereby inhibiting the action of myostatin [80].”
Background
Metadata
- Authors
- Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., & Eckardt, K.
- Affiliations
- German Center for Diabetes Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Norwegian School of Sport Sciences (NO)
- Charles University (CZ)
- University of Oslo (NO)
- Corresponding author
- Eckardt, Kristin
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 450
- Issue
- 2
- Pages
- 1089-1094
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2050986782
- Cited by
- 209
- References
- 32
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 24 · 2023: 16 · 2022: 35 · 2021: 22 · 2020: 16 · 2019: 12 · 2018: 10 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 1
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Deutsche Forschungsgemeinschaft (EC 440/1-1)
- Leibniz-Gemeinschaft (SAW-FBN-2013-3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- decorin, myokines, muscle contraction, muscle hypertrophy, resistance training, skeletal muscle growth, myostatin, MyoD, follistatin, atrogin-1, MuRF1, ubiquitin ligase, muscle atrophy, myotubes, exercise training
- MeSH terms
- Adolescent, Adult, Animals, Cells, Cultured, Female, Humans, Male, Muscle Contraction, Physical Conditioning, Animal, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Mice, Decorin
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