Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

Boden, Guenther; Homko, Carol; Mozzoli, Maria; Showe, Louise C.; Nichols, Calen; Cheung, Peter

doi:10.2337/diabetes.54.3.880

Cited by 129Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

Boden, Guenther, Homko, Carol, Mozzoli, Maria, Showe, Louise C., Nichols, Calen, Cheung, Peter·2005·Diabetes

DOI 10.2337/diabetes.54.3.880

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Abstract

Thiazolidinediones (TZDs) are a new class of insulin-sensitizing drugs. To explore how and in which tissues they improve insulin action, we obtained fat and muscle biopsies from eight patients with type 2 diabetes before and 2 months after treatment with rosiglitazone (n = 5) or troglitazone (n = 3). TZD treatment was associated with a coordinated upregulation in the expression of genes and synthesis of proteins involved in fatty acid uptake, binding, beta-oxidation and electron transport, and oxidative phosphorylation in subcutaneous fat but not in skeletal muscle. These changes were accompanied by a 13% increase in total body fat oxidation, a 20% decrease in plasma free fatty acid levels, and a 46% increase in insulin-stimulated glucose uptake. We conclude that TZDs induced a coordinated stimulation of fatty acid uptake, oxidation, and oxidative phosphorylation in fat of diabetic patients and thus may have corrected, at least partially, a recently recognized defect in patients with type 2 diabetes consisting of reduced expression of genes related to oxidative metabolism and mitochondrial function.

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“Administration of thiazolidinediones induces changes in mitochondrial content and remodeling in white adipocytes concomitantly with an improvement in insulin sensitivity (170, 173, 177, 190, 194 -198).”
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Authors: Boden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P.
Affiliations: Temple University (US)
The Wistar Institute (US)
ORCID: Showe, Louise C.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-03-01
Volume: 54
Issue: 3
Pages: 880-885
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.3.880
OpenAlex: W2031020280
Cited by: 129
References: 44
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 6
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
National Institutes of Health
National Institute on Aging (R01 AG 15353)
National Heart, Lung, and Blood Institute (R01-HL-0733267)
National Institute on Drug Abuse (P30-DA13429, P30DA013429)
National Cancer Institute (P30CA010815)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK58895, R01DK066003, R01DK058895)
NIH Clinical Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: thiazolidinediones, rosiglitazone, troglitazone, type 2 diabetes, insulin sensitizers, fatty acid uptake, fatty acid oxidation, adipose tissue, skeletal muscle, fatty acid beta-oxidation, oxidative phosphorylation, mitochondrial function, plasma free fatty acids, insulin-stimulated glucose uptake, gene expression
MeSH terms: Rosiglitazone, Troglitazone, Adipose Tissue, Biological Transport, Chromans, Diabetes Mellitus, Type 2, Fatty Acids, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Oxidation-Reduction, Oxidative Phosphorylation, Up-Regulation, Gene Expression, Thiazolidinediones

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Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

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