Cited by 342Circadian rhythm and melatoninInflammatory mediators and NSAID effectsmelanin and skin pigmentation

Melatonin: A Pleiotropic Molecule Regulating Inflammation

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Radogna, Flavia, Diederich, Marc, Ghibelli, Lina·2010·Biochemical Pharmacology

Abstract

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves. With its endocrine and paracrine effects, melatonin differentially modulates pro-inflammatory enzymes, controls production of inflammatory mediators such as cytokines and leukotrienes and regulates the lifespan of leukocytes by interfering with apoptotic processes. Moreover, its potent antioxidant ability allows scavenging of oxidative stress in the inflamed tissues. The interesting timing of pro- and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation. This review aims at giving a comprehensive overview of the various inflammatory pathways regulated by this pleiotropic hormone.

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Registry

Crossref · 10.1016/j.bcp.2010.07.041

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  • Melatonin can stimulate release of pro-inflammatory factors depending on concurrent conditions, with response limited to early treatment stages.

    “However, melatonin can also stimulate the release of pro-inflammatory factors depending on the concurrent conditions, although this response seems to be limited to early treatment stages and needs to be better investigated [454].”

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Authors
Radogna, F., Diederich, M., & Ghibelli, L.
Affiliations
  • University of Rome Tor Vergata (IT)
  • Hôpital Kirchberg (LU)
Corresponding author
Ghibelli, Lina
Venue
Biochemical Pharmacology
Publisher
Elsevier BV
Published
2010-12
Volume
80
Issue
12
Pages
1844-1852
ISSN
0006-2952 (ISSN-L)
OpenAlex
W1984537429
Cited by
342
References
132
Citations by year
2026: 19 · 2025: 13 · 2024: 11 · 2023: 23 · 2022: 27 · 2021: 22 · 2020: 20 · 2019: 20 · 2018: 31 · 2017: 22 · 2016: 22 · 2015: 31 · 2014: 31 · 2013: 25 · 2012: 15
FWCI
1.61
Type
journal article
Language
en
Open access
Locations
  • Biochemical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders
  • Een Häerz fir kriibskrank Kanner
  • Recherches Scientifiques Luxembourg
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
melatonin, inflammation, immune regulation, leukocytes, circadian rhythm, pineal gland, cytokines, leukotrienes, lipoxygenase, apoptosis, oxidative stress, antioxidant activity
MeSH terms
Animals, Anti-Inflammatory Agents, Antioxidants, Cell Survival, Humans, Inflammation, Leukocytes, Melatonin, Pineal Gland, Signal Transduction, Arachidonic Acid, Apoptosis, Reactive Oxygen Species, Oxidative Stress

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