Melatonin improves metabolic syndrome induced by high fructose intake in rats
Abstract
Abstract: In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats. Feeding of a diet containing 60% fructose (HFD) for 4 or 6 wk caused increased serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, leptin, and lipid peroxide concentrations as well as hepatic triglyceride and cholesterol concentrations, and relative intra‐abdominal fat and liver weights. The 4‐ or 6‐wk HFD feeding reduced serum high‐density lipoprotein cholesterol and adiponectin concentrations. The 6‐wk HFD feeding increased serum tumor necrosis factor‐α concentration and hepatic lipid peroxide concentration and lowered hepatic reduced glutathione concentration. Daily intraperitoneal administration of melatonin (1 or 10 mg/kg body weight), starting at 4‐wk HFD feeding, attenuated these changes at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. In an oral glucose tolerance test, rats with 4‐ or 6‐wk HFD feeding showed higher serum insulin response curve and normal serum glucose response curve when compared with the corresponding animals that received the control diet. The 4‐ or 6‐wk HFD feeding caused insulin resistance, judging from the scores of HOMR‐IR and QUICKI, which are indices of insulin resistance. The daily administered melatonin (1 or 10 mg/kg body weight) ameliorated the higher serum insulin response curve in the oral glucose tolerance test and insulin resistance at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. These results indicate that melatonin improves metabolic syndrome induced by high fructose intake in rats.
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Melatonin administration decreases the circulating leptin levels in most animal models, however, the results are inconsistent in human studies.
“Melatonin administration decreases the circulating leptin levels in most animal models, 29,30 however, the results are inconsistent in human studies. 19,31”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [29]
Different animal models and clinical studies approved the melatonin's effect on the treatment of circulating adiponectin.
“Different animal models and clinical studies approved the melatonin's effect on the treatment of circulating adiponectin. 19,29,30”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [29]
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- Authors
- Kitagawa, A., Ohta, Y., & Ohashi, K.
- Affiliations
- Shigakkan University (JP)
- Fujita Health University (JP)
- Corresponding author
- Ohta, Yoshiji
- ORCID
- Kitagawa, Akira
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2012-05
- Volume
- 52
- Issue
- 4
- Pages
- 403-413
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2101370818
- Cited by
- 116
- References
- 58
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 18 · 2016: 6 · 2015: 6 · 2014: 18 · 2013: 11 · 2012: 5
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- melatonin, metabolic syndrome, high-fructose diet, insulin resistance, glucose tolerance, lipid metabolism, adiponectin, leptin, TNF-α, oxidative stress, liver cholesterol, intra-abdominal fat
- MeSH terms
- Analysis of Variance, Animals, Antioxidants, Blood Glucose, Body Weight, Cholesterol, Diet, Fructose, Glucose Tolerance Test, Insulin, Insulin Resistance, Lipid Peroxides, Lipids, Liver, Male, Melatonin, Uric Acid, Rats, Wistar, Oxidative Stress, Metabolic Syndrome, Rats, Adipokines
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