Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation
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Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant activated microglia play a pivotal role in the pathogenesis of depression. Paricalcitol (Pari), a vitamin D2 analogue, has been demonstrated to exert anti-inflammative effects on renal and cardiovascular diseases. In this study, mice were pretreated with Pari before being induced to acute depression-like behaviors by systemic lipopolysaccharide (LPS) injection. To determine the therapeutic effects of Pari, alterations in acute body weight, sucrose preference, forced swimming and tail suspension tests were assessed. Then, alterations of pro-inflammation cytokine IL1-β level and microglia activity in the hypothalamus, which are involved in the pathophysiology of depression, were examined. The results showed that Pari significantly alleviated systemic LPS injection induced depressive-like behaviors as shown by increased sucrose preference and decreased TST and FST immobility. Pari could specifically regulate microglia-mediated neuroinflammation process and local activity of renin-angiotensin system to exert its anti-depressant effects. This study demonstrated a potential for paricalcitol in treating depressive symptoms induced by systemic inflammation, particularly in patients with chronic hypertension.
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The severity of depression is associated with the secretion level of circulating cytokines and chemokines, which compromise the BBB and then activate central immune responses.
“Our previous findings and those of others indicate that the severity of depression is associated with the secretion level of circulating cytokines and chemokines, which compromise the blood–brain barrier (BBB) and then activate central immune responses [10–13].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [12]
The Introduction (page not provided) associates depression severity with circulating proinflammatory cytokines and says that compromised BBB and choroid plexus barriers lead to central immune activation. It does not extend the severity association to chemokines or say that circulating cytokines and chemokines themselves compromise the BBB. (LLM, conf=0.88)
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Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Targeting the NLRP3 inflammasome in inflammatory diseases
Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works
Inflammation meets cancer, with NF-κB as the matchmaker
Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,378 · see citing works
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944 · see citing works
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939 · see citing works
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
Shih, R., Wang, C.-Y., & Yang, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 912 · see citing works
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works
Vitamin D deficiency and depression in adults: systematic review and meta-analysis
Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.106666 · Cited by 820 · see citing works
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Microglia: Dynamic Mediators of Synapse Development and Plasticity
Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.008 · Cited by 661 · see citing works
The organization of the stress system and its dysregulation in depressive illness
Gold, P. W. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.163 · Cited by 654 · see citing works
Neuroimmune mechanisms of depression
Hodes, G. E., Kana, V., Menard, C., Merad, M., & Russo, S. J. (2015) · Nature Neuroscience · doi:10.1038/nn.4113 · Cited by 585 · see citing works
The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses
Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580 · see citing works
Lateral hypothalamic circuits for feeding and reward
Stuber, G. D., & Wise, R. A. (2016) · Nature Neuroscience · doi:10.1038/nn.4220 · Cited by 519 · see citing works
Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443 · see citing works
Pan, Y., Chen, X.-Y., Zhang, Q.-Y., & Kong, L.-D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.04.007 · Cited by 405 · see citing works
Nieh, E. H., Vander Weele, C. M., Matthews, G. A., Presbrey, K. N., Wichmann, R., Leppla, C. A., Izadmehr, E. M., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.035 · Cited by 387 · see citing works
Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice
Biesmans, S., Meert, T. F., Bouwknecht, J. A., Acton, P. D., Davoodi, N., Haes, P. D., Kuijlaars, J., Langlois, X., Matthews, L. J. R., Donck, L. V., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/271359 · Cited by 382 · see citing works
Immune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
Increase in Interleukin-1β in Late-Life Depression
Thomas, A. J., Davis, S., Morris, C., Jackson, E., Harrison, R., & O’Brien, J. T. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.175 · Cited by 291 · see citing works
Zhang, Z., Zhang, Y., Ning, G., Deb, D. K., Kong, J., & Li, Y. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803751105 · Cited by 289 · see citing works
Self-citationUnder pressure: the search for the essential mechanisms of hypertension
Coffman, T. M. (2011) · Nature Medicine · doi:10.1038/nm.2541 · Cited by 286 · see citing works
Moieni, M., Irwin, M. R., Jevtic, I., Olmstead, R., Breen, E. C., & Eisenberger, N. I. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.17 · Cited by 273 · see citing works
Tan, X., Wen, X., & Liu, Y. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007060666 · Cited by 252 · see citing works
Walker, F. R., Beynon, S. B., Jones, K., Zhao, Z., Kongsui, R., Cairns, M. J., & Nilsson, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.010 · Cited by 237 · see citing works
Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments
Haneklaus, M., O'Neill, L. A. J., & Coll, R. C. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.004 · Cited by 230 · see citing works
Shaffer, J. A., Edmondson, D., Wasson, L. T., Falzon, L., Homma, K., Ezeokoli, N., Li, P., & Davidson, K. W. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000044 · Cited by 227 · see citing works
Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3723-13.2014 · Cited by 209 · see citing works
Fleegal, M. A., Doghu, S., & Banks, W. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.158 · Cited by 181 · see citing works
Maslanik, T., Mahaffey, L., Tannura, K., Beninson, L., Greenwood, B. N., & Fleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.014 · Cited by 156 · see citing works
Yu, Y. W. ‐., Chen, T., Hong, C., Chen, H.-M., & Tsai, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300172 · Cited by 150 · see citing works
Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-κB in the Paraventricular Nucleus
Cardinale, J. P., Sriramula, S., Mariappan, N., Agarwal, D., & Francis, J. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.182154 · Cited by 149 · see citing works
VDR Attenuates Acute Lung Injury by Blocking Ang-2-Tie-2 Pathway and Renin-Angiotensin System
Kong, J., Zhu, X., Shi, Y., Liu, T., Chen, Y., Bhan, I., Zhao, Q., Thadhani, R., & Li, Y. C. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1146 · Cited by 149 · see citing works
Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking
Carús-Cadavieco, M., Gorbati, M., Li, Y., Bender, F., van der Veldt, S., Kosse, C., Börgers, C., Lee, S. Y., Ramakrishnan, C., Hu, Y., et al. (2017) · Nature · doi:10.1038/nature21066 · Cited by 133 · see citing works
Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129 · see citing works
Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures
Dominguez‐Meijide, A., Rodriguez-Perez, A. I., Díaz-Ruiz, C., Guerra, M. J., & Labandeira-García, J. L. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.013 · Cited by 113 · see citing works
Genetic approaches to hypothalamic-pituitary-adrenal axis regulation
Arnett, M. G., Muglia, L. M., Laryea, G., & Muglia, L. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.215 · Cited by 105 · see citing works
Delpech, J.-C., Thomazeau, A., Madore, C., Bosch‐Bouju, C., Larrieu, T., Lacabanne, C., Rémus-Borel, J., Aubert, A., Joffre, C., Nadjar, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.127 · Cited by 104 · see citing works
Cordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works
Role of brain transmigrating neutrophils in depression-like behavior during systemic infection
Aguliar-Valles, A., Kim, J., Jung, S., Woodside, B., & Luheshi, G. N. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.137 · Cited by 97 · see citing works
Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
Niculescu, A. B., Levey, D. F., Le-Niculescu, H., Niculescu, E. M., Kurian, S. M., & Salomon, D. R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.180 · Cited by 81 · see citing works
Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation
Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8428-4 · Cited by 81 · see citing works
Jiang, P., Zhang, W., Huan-de, L., Cai, H., Liu, Y., & Chen, L.-Y. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.017 · Cited by 80 · see citing works
Glia in the cytokine-mediated onset of depression: fine tuning the immune response
Jo, W. K., Zhang, Y., Emrich, H. M., & Dietrich, D. E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00268 · Cited by 77 · see citing works
Self-citationShih, R., & Yang, C. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-86 · Cited by 66 · see citing works
Shi, Z., Ren, H., Huang, Z., Peng, Y., He, B., Yao, X., Yuan, T.-F., & Su, H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0212-9 · Cited by 62 · see citing works
Self-citationHuo, Y., Lu, X., Wang, X., Wang, X., Chen, L., Guo, H., Zhang, M., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25071490 · Cited by 45 · see citing works
Lee, A. S., Jung, Y. J., Nguyen, T. T., Lee, S., Kim, W. B., Kang, K. P., & Park, S. K. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2516 · Cited by 27 · see citing works
Qadri, F., Rimmele, F., Mallis, L., Häuser, W., Dendorfer, A., Jöhren, O., Dominiak, P., Leeb-Lundberg, L. M. F., & Bäder, M. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0206 · Cited by 14 · see citing works
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Carlessi, A. S., Borba, L. A., Zugno, A. I., Quevedo, J., & Réus, G. Z. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14631 · Cited by 243 · see citing works
Heras, N. D. L., Giménez, V. M. M., Ferder, L., Manucha, W. A., & Lahera, V. (2020) · Antioxidants · doi:10.3390/antiox9090897 · Cited by 129 · see citing works
Cordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works
Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95 · see citing works
Self-citationChen, Y., Zhang, Y., Wang, J., Li, S., Wang, Y., Zhang, Z., Zhang, J., Xin, C., Wang, Y., & Rong, P. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14207 · Cited by 97 · see citing works
Self-citationXiao, K., Luo, Y., Liang, X., Tang, J., Wang, J., Xiao, Q., Qi, Y., Li, Y., Zhu, P., Yang, H., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01571-9 · Cited by 68 · see citing works
Vitamin D as a Risk Factor for Multiple Sclerosis: Immunoregulatory or Neuroprotective?
Gombash, S. E., Lee, P. W., Sawdai, E., & Lovett‐Racke, A. E. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.796933 · Cited by 59 · see citing works
Lü, C., Gao, R., Zhang, Y., Jiang, N., Chen, Y., Sun, J., Wang, Q., Fan, B., Liu, X., & Wang, F. (2021) · Food & Function · doi:10.1039/d1fo00547b · Cited by 52 · see citing works
Self-citationHuo, Y., Lu, X., Wang, X., Wang, X., Chen, L., Guo, H., Zhang, M., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25071490 · Cited by 45 · see citing works
Li, T. X., Sun, S., Cui, L., Wang, S., Peng, Z., Tan, Q., Hou, W., & Cai, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.025 · Cited by 44 · see citing works
He, Y., Li, W., Wang, Y., Tian, Y., Chen, X., Wu, Z., Lan, T., Li, Y., Bai, M., Liu, J., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.131 · Cited by 44 · see citing works
Self-citationYan, T., Li, F., Xiong, W.-L., Wu, B., Xiao, F., He, B., & Jia, Y. (2020) · Environmental Toxicology · doi:10.1002/tox.23073 · Cited by 41 · see citing works
Rebai, R., Jasmin, L., & Boudah, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111246 · Cited by 40 · see citing works
He, M., Shi, Z., Qin, M., Sha, N., Li, Y., Liao, D., Lin, F., Shu, B., Sun, Y., Yuan, T., et al. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500287 · Cited by 39 · see citing works
Self-citationHuman torpor: translating insights from nature into manned deep space expedition
Shi, Z., Qin, M., Huang, L., Xu, T., Chen, Y., Hu, Q., Peng, S., Peng, Z., Qu, L., Chen, S., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12671 · Cited by 32 · see citing works
Self-citationLü, C., Wei, Z., Wang, Y., Li, S., Tong, L., Liu, X., Fan, B., & Wang, F. (2022) · Food & Function · doi:10.1039/d2fo01437h · Cited by 29 · see citing works
Self-citationYang, F., Bi, Y., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.635762 · Cited by 27 · see citing works
Li, W., Qin, X., Poon, C. C., Wong, M., Feng, R., Wang, J., Lin, F., Sun, Y., Liu, S., Wang, Y., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4441 · Cited by 27 · see citing works
Self-citationNight shift hormone: How does melatonin affect depression?
Kholghi, G., Eskandari, M., Saadlou, M.-S. S. Q., Zarrindast, M., & Vaseghi, S. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113835 · Cited by 26 · see citing works
Yu, H., Yu, B., Qin, X., & Shan, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.005 · Cited by 25 · see citing works
Feng, R., He, M., Li, Q., Liang, X., Tang, D., Zhang, J., Liu, S., Lin, F., & Zhang, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6777 · Cited by 25 · see citing works
Self-citationZhang, D., Qiao, L., & Fu, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109528 · Cited by 24 · see citing works
Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs
Li, M., Sun, X., Li, Q., Li, Y., Luo, C., Huang, H., Chen, J., Gong, C.-Z., Li, Y., Zheng, Y., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.043 · Cited by 23 · see citing works
Gong, P., Wang, J., Long, H., Yang, W., Chen, X., Li, N., Chen, F., Zhang, J., & Guo, Y. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70080 · Cited by 21 · see citing works
Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes
Zhang, H., Wu, X., Wei, Y., & Zhu, C. H. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b02838 · Cited by 21 · see citing works
Bian, H., Xiao, L., Liang, L., Xie, Y., Wang, H., & Wang, G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108259 · Cited by 17 · see citing works
Fu, Y.-F., Guo, Y.-X., Xia, S., Zhou, T., Zhao, Y., Jia, Z., & Zhang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112408 · Cited by 16 · see citing works
Self-citationAygün, H., Ayyıldız, M., & Ağar, E. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.106208 · Cited by 15 · see citing works
Kong, X., Zhao, J. W., Gao, H., Wang, W., Wang, J., & Tan, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103808 · Cited by 12 · see citing works
Targeting Underlying Inflammation in Carcinoma Is Essential for the Resolution of Depressiveness
Borovčanin, M., Vesić, K., Arsenijević, D., Milojević‐Rakić, M., Mijailović, N. R., & Jovanović, I. (2023) · Cells · doi:10.3390/cells12050710 · Cited by 11 · see citing works
Liu, Y., Jiang, Q., Huang, Y., Zhang, X., Kang, H., Yu, C., Xia, Y., Liu, Y., & Zhang, H. (2025) · Cells · doi:10.3390/cells14221780 · Cited by 10 · see citing works
Alzarea, S. I., Alhassan, H. H., Alzarea, A. I., Al‐Oanzi, Z. H., & Afzal, M. (2022) · Brain Sciences · doi:10.3390/brainsci12050655 · Cited by 8 · see citing works
He, J., Gao, Z., Li, X., Zhao, L., Tian, X., & Gao, B. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149656 · Cited by 7 · see citing works
Lima, L. C. D., Oliveira, B. D. S., Nunes, I. S. S., Oliveira, T. H., Toscano, E. C. D. B., Machado, C. A., Martins, R. F., Sarto, J. L. D., Vieira, É. L. M., Menezes, G. B., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115643 · Cited by 6 · see citing works
Liu, W., Guan, L., Xu, W., Liu, Y., Wang, W., Fan, B., & Chen, G. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106828 · Cited by 6 · see citing works
Yoo, Y., Baek, S. Y., Lee, H., Lee, J., Lee, H., Lee, H., Ma, H., Kim, Y., Choi, H., Lee, J. T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02981 · Cited by 6 · see citing works
Wang, Y.-F., Xie, Y.-L., Liu, P.-Q., Lv, H., Guan, M.-T., Cong, J.-C., Wang, Y., & Xu, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.043 · Cited by 6 · see citing works
Self-citationPARP14 inhibits microglial activation via NNT to alleviate depressive-like behaviors in mice
Yu, X., Yang, T., Wu, D., Xu, C., Li, Z., Sun, A., Gao, S., Li, H., Fan, Z., & Huang, R. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.02.017 · Cited by 5 · see citing works
El-Waseif, A. G., Elshal, M., El‐Kashef, D. H., & Abu‐Elsaad, N. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117307 · Cited by 4 · see citing works
Microglia as a Potential Target for Antidepressant: A Systematic Review on Preclinical studies
Lisnasari, B. R. W., Ardianto, C., & Khotib, J. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00555 · Cited by 4 · see citing works
Pechacek, K. M., & Haar, C. V. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113998 · Cited by 3 · see citing works
Cheng, Y., Fei, Y., Xu, Z., Huang, R., Jiang, Y., Sun, L., Wang, X., Yu, S., Luo, Y., Mao, X., et al. (2024) · Toxics · doi:10.3390/toxics12120918 · Cited by 3 · see citing works
Sakakima, H., Nojima, N., Tani, A., Nakanishi, K., Matsuoka, T., Matsuzaki, R., Kakimoto, S., Kato, Y., Tachibe, Y., Inadome, M., et al. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04915-w · Cited by 3 · see citing works
Lu, Y., Zheng, Y., Sun, X., Song, Y., Zhou, Y., Shen, F., Huang, R., & Xu, Z. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02207-y · Cited by 2 · see citing works
Li, X., Hua, Y., Li, H., Feng, Y., Wu, C., Hu, X., Zhang, Z., Zhou, X., & Dong, X. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.037 · Cited by 2 · see citing works
Self-citationYu, X., Gao, S., Chen, Y., Ye, L., Wang, B., Xu, L., Sun, A., Liang, C., Lu, S., Li, X., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00862 · Cited by 2 · see citing works
Self-citationVitamin D Deficiency - New Insights
Fedotova, J. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100904 · Cited by 1 · see citing works
Pharmacological Efficacy and Mechanism of Vitamin D in the Treatment of “Kidney-Brain” Disorders
Zhang, J., Wang, Y.-J., & Zhang, Y. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105820
Self-citationZhou, J., Wu, Z., Feng, Z., Li, J., Wen, Y., Jiang, M., & Feng, S. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115033
Zhang, Q., Ding, F., Qin, X., Guo, Y.-X., Liu, Q., Bai, M., Zhou, T., Zhu, X., Yang, H., & Zhang, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117635
Self-citationPeng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20315881
Self-citationMunir, M. M., Zhou, X., & Chang, D. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12817-4
Paricalcitol improves cognitive dysfunction associated with chronic post-thoracotomy pain in rats
Zheng, N., Zhang, Y., Cheng, C., Chin, M., Qing, W., & Liao, Q. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100238
Self-citation
- Authors
- He, M.-C., Shi, Z., Sha, N.-N., Chen, N., Peng, S.-Y., Liao, D.-F., Wong, M.-S., Dong, X.-L., Wang, Y.-J., Yuan, T.-F., & Zhang, Y.
- Affiliations
- Shanghai University of Traditional Chinese Medicine (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Hong Kong Polytechnic University (HK)
- Corresponding author
- Wang, Yong-jun
- Yuan, Ti-fei
- Zhang, Yan
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 163
- Pages
- 1-8
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2914443465
- Cited by
- 54
- References
- 61
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 3 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 11 · 2019: 4
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Natural Science Foundation of China (81730107, 81774329)
- Shanghai Municipal Commission of Health and Family Planning (2018BR03)
- Natural Science Foundation of Shanghai (17ZR1430800)
- Program for Innovative Research Team (2015RA4002)
- National Key R & D Program (2018YFC1704302)
- Ministry of Science and Technology of China
- China Postdoctoral Science Foundation (2018T110405)
- Longhua Medical Innovation Team Program (LYCX-01)
- Science and Technology Commission of Shanghai Municipality (18QA1403700)
- Shanghai Rising Star Program (18JC1420304, 18140901700)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- paricalcitol, depression, lipopolysaccharide, neuroinflammation, microglial activation, hypothalamus, renin-angiotensin system, IL-1β, chronic inflammation, depression-like behavior, chronic hypertension
- MeSH terms
- Animals, Antidepressive Agents, Depression, Ergocalciferols, Hypothalamus, Inflammation, Lipopolysaccharides, Male, Mice, Inbred C57BL, Microglia, Inflammation Mediators, Mice
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