Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation
Abstract
Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression.
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The severity of depression is associated with the secretion level of circulating cytokines and chemokines, which compromise the BBB and then activate central immune responses.
“Our previous findings and those of others indicate that the severity of depression is associated with the secretion level of circulating cytokines and chemokines, which compromise the blood–brain barrier (BBB) and then activate central immune responses [10–13].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [13]
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- Authors
- Shi, Z., Ren, H., Huang, Z., Peng, Y., He, B., Yao, X., Yuan, T.-F., & Su, H.
- Affiliations
- University of Macau (MO)
- Sun Yat-sen University (CN)
- Nanjing Normal University (CN)
- Corresponding author
- Yao, Xiaoli
- Yuan, Ti-Fei
- Su, Huanxing
- Venue
- Molecular Neurobiology
- Published
- 2016-11-04
- Volume
- 54
- Issue
- 9
- Pages
- 7327-7334
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2547255383
- Cited by
- 62
- References
- 44
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 2 · 2016: 1
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- fish oil, omega-3 polyunsaturated fatty acids, lipopolysaccharide, neuroinflammation, depression-like behavior, cytokines, stress hormones, hypothalamus, adrenal gland, oxidative stress, neuroprotection
- MeSH terms
- Animals, Depression, Fish Oils, Inflammation, Lipopolysaccharides, Male, Mice, Inbred C57BL, Oxidative Stress, Mice
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