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Cited by 471Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 177 of the 179 references it cites were found in a registry or an index.

Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come

Koerner, Antje, Kratzsch, Jürgen, Kiess, Wieland·2005·Best Practice & Research Clinical Endocrinology & Metabolism
DOI 10.1016/j.beem.2005.07.008
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Abstract

With the growing prevalence of obesity, scientific interest in the biology of adipose tissue has been extended to the secretory products of adipocytes, since they are increasingly shown to affect several aspects in the pathogenesis of obesity-related diseases. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centred in the hypothalamus. In recent years, a number of additional signalling molecules secreted by adipose tissue have been discovered, commonly referred to as 'adipocytokines'. Among these, adiponectin is perhaps the most interesting and promising compound for the clinician since it has profound protective actions in the pathogenesis of diabetes and cardiovascular disease. Adiponectin is low in obese subjects and, in particular, insulin-resistant patients. In contrast, resistin seems to be of greater relevance in relation to the immune stress response than in the regulation of glucose homeostasis. However, inflammatory processes have recently been connected with the development of atherosclerosis. Finally, little is known regarding the clinical relevance of visfatin. Recent research has revealed many functions of adipocytokines extending far beyond metabolism, such as immunity, cancer and bone formation. This report aims to review some of the recent topics of adipocytokine research that may be of particular importance.

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Crossref · 10.1016/j.beem.2005.07.008

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177 of 177 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 2

  1. Böttner A, Kratzsch J, Seidel B, et al. Adiponectin expression is dependent on differentiation of adipocytes. In press.
  2. Hug, 2005, Medicine. Visfatin: a new adipokine. Science, 307, 366

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Metadata

Authors
Koerner, A., Kratzsch, J., & Kiess, W.
Affiliations
  • Leipzig University (DE)
  • University Hospital Leipzig (DE)
ORCID
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2005-12
Volume
19
Issue
4
Pages
525-546
ISSN
1521-690X (ISSN-L)
DOI
10.1016/j.beem.2005.07.008
OpenAlex
W1973692442
Cited by
471
References
179
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 19 · 2020: 4 · 2019: 11 · 2018: 21 · 2017: 15 · 2016: 22 · 2015: 27 · 2014: 33 · 2013: 33 · 2012: 37
FWCI
4.46
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
adipokines, leptin, resistin, adiponectin, visfatin, obesity, adipose tissue, insulin resistance, diabetes mellitus, cardiovascular disease, atherosclerosis, inflammation, immune response, cancer, bone formation
MeSH terms
Adipose Tissue, Animals, Cardiovascular Diseases, Diabetes Mellitus, Humans, Insulin Resistance, Cytokines, Leptin, Mice, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase

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