The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Hydrogel as a bioactive material to regulate stem cell fate
Open accessAbstract
The encapsulation of stem cells in a hydrogel substrate provides a promising future in biomedical applications. However, communications between hydrogels and stem cells is complicated; various factors such as porosity, different polymer types, stiffness, compatibility and degradation will lead to stem cell survival or death. Hydrogels mimic the three-dimensional extracellular matrix to provide a friendly environment for stem cells. On the other hand, stem cells can sense the surroundings to make the next progression, stretching out, proliferating or just to remain. As such, understanding the correlation between stem cells and hydrogels is crucial. In this Review, we first discuss the varying types of the hydrogels and stem cells, which are most commonly used in the biomedical fields and further investigate how hydrogels interact with stem cells from the perspective of their biomedical application, while providing insights into the design and development of hydrogels for drug delivery, tissue engineering and regenerative medicine purpose. In addition, we compare the results such as stiffness, degradation time and pore size as well as peptide types of hydrogels from respected journals. We also discussed most recently magnificent materials and their effects to regulate stem cell fate.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Highly stretchable and tough hydrogels
Sun, J.-Y., Zhao, X., Illeperuma, W. R. K., Chaudhuri, O., Oh, K. H., Mooney, D. J., Vlassak, J. J., & Suo, Z. (2012) · Nature · doi:10.1038/nature11409 · Cited by 5,481
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Hydrogels for biomedical applications
Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Cited by
Synthetic alternatives to Matrigel
Aisenbrey, E. A., & Murphy, W. L. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0199-8 · Cited by 1,016
Thermo-responsive polymers and their application as smart biomaterials
Kim, Y.-J., & Matsunaga, Y. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00157f · Cited by 568
Bioactive hydrogels for bone regeneration
Bai, X., Gao, M., Syed, S., Zhuang, J., Xu, X., & Zhang, X.-Q. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2018.05.006 · Cited by 556
Self-citationMultifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
Kurian, A. G., Singh, R. K., Patel, K. D., Lee, J.-H., & Kim, H.-W. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.027 · Cited by 444
Eke, G., Mangir, N., Hasirci, N., MacNeil, S., & Hasirci, V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.021 · Cited by 417
Metadata
- Authors
- Tsou, Y.-H., Khoneisser, J., Huang, P.-C., & Xu, X.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 1
- Issue
- 1
- Pages
- 39-55
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W2348656062
- Cited by
- 317
- References
- 155
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
