The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering
Open accessAbstract
The aim of this study was to design a dermal substitute containing adipose derived stem cells (ADSC) that can be used to improve the regeneration of skin on difficult wound beds by stimulating rapid neovascularization. This was achieved by first synthesizing methacrylated gelatin (GelMA) and methacrylated hyaluronic acid (HAMA) precursors which could be stored at -80 oC after lyophilisation. Polymer precursors were then dissolved in media (in 15:1 ratio), ADSCs added together with the photoinitiator and crosslinked with 40 s of UV. Hydrogels degraded by 50% over 3 weeks in an in vitro environment. ADSC loaded hydrogels could be easily handled with forceps (compressive modulus was 6 kPa). Transparency of the gel would allow a full field-of-view of a wound site. The hydrogels provided a suitable microenvironment for ADSC proliferation as shown by the filopodia observed in confocal micrographs. In vivo studies demonstrated that stem cell loaded hydrogels increased vascularization by up to 3 fold compared to their cell free counterparts. In conclusion, GelMA/HAMA hydrogels loaded with ADSC showed the desired proliferative and angiogenic properties essential to promote angiogenesis for wound healing and improving survival of tissue engineered skin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Progress and opportunities for tissue-engineered skin
MacNeil, S. (2007) · Nature · doi:10.1038/nature05664 · Cited by 1,112
Self-citationReciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Jiang, P., Du, W., Mancuso, A., Wellen, K. E., & Yang, X. (2013) · Nature · doi:10.1038/nature11776 · Cited by 491
A simple procedure for the long-term cultivation of chicken embryos
Auerbach, R., Kubai, L., Knighton, D., & Folkman, J. (1974) · Developmental Biology · doi:10.1016/0012-1606(74)90316-9 · Cited by 439
Shin, H., Olsen, B. D., & Khademhosseini, A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.050 · Cited by 400
Synthesis and Characterization of Hybrid Hyaluronic Acid-Gelatin Hydrogels
Camci-Unal, G., Cuttica, D., Annabi, N., Demarchi, D., & Khademhosseini, A. (2013) · Biomacromolecules · doi:10.1021/bm3019856 · Cited by 343
Hydrogel as a bioactive material to regulate stem cell fate
Tsou, Y.-H., Khoneisser, J., Huang, P.-C., & Xu, X. (2016) · Bioactive Materials · doi:10.1016/j.bioactmat.2016.05.001 · Cited by 317
EGF containing gelatin-based wound dressings
Ulubayram, K. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00287-8 · Cited by 316
Xiao, W., He, J., Nichol, J. W., Wang, L., Hutson, C. B., Wang, B., Du, Y., Fan, H., & Khademhosseini, A. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.016 · Cited by 315
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Hyaluronic Acid: Redefining Its Role
Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., & Brun, P. (2020) · Cells · doi:10.3390/cells9071743 · Cited by 533
Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations
Zeng, Q., Qi, X., Shi, G., Zhang, M., & Haick, H. (2022) · ACS Nano · doi:10.1021/acsnano.1c08411 · Cited by 532
Chouhan, D., Dey, N., Bhardwaj, N., & Mandal, B. B. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119267 · Cited by 522
Recent Advances in Photo-Crosslinkable Hydrogels for Biomedical Applications
Choi, J. R., Yong, K. W., Choi, J. Y., & Cowie, A. C. (2019) · BioTechniques · doi:10.2144/btn-2018-0083 · Cited by 403
Metadata
- Authors
- Eke, G., Mangir, N., Hasirci, N., MacNeil, S., & Hasirci, V.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 129
- Pages
- 188-198
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2596787754
- Cited by
- 417
- References
- 29
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. https://app.cochat.ai/papers/10.1016/j.biomaterials.2017.03.021
- The paper
- Eke, G., Mangir, N., Hasirci, N., MacNeil, S., & Hasirci, V. (2017). Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials. https://doi.org/10.1016/j.biomaterials.2017.03.021
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
