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Cited by 109biodegradable polymer synthesis and propertiesPolymer composites and self-healingHydrogels: synthesis, properties, applications

Rational design of biodegradable thermoplastic polyurethanes for tissue repair

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Xu, Cancan, Hong, Yi·2022·Bioactive Materials
DOI 10.1016/j.bioactmat.2021.11.029PMC PMC8940769
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Abstract

As a type of elastomeric polymers, non-degradable polyurethanes (PUs) have a long history of being used in clinics, whereas biodegradable PUs have been developed in recent decades, primarily for tissue repair and regeneration. Biodegradable thermoplastic (linear) PUs are soft and elastic polymeric biomaterials with high mechanical strength, which mimics the mechanical properties of soft and elastic tissues. Therefore, biodegradable thermoplastic polyurethanes are promising scaffolding materials for soft and elastic tissue repair and regeneration. Generally, PUs are synthesized by linking three types of changeable blocks: diisocyanates, diols, and chain extenders. Alternating the combination of these three blocks can finely tailor the physio-chemical properties and generate new functional PUs. These PUs have excellent processing flexibilities and can be fabricated into three-dimensional (3D) constructs using conventional and/or advanced technologies, which is a great advantage compared with cross-linked thermoset elastomers. Additionally, they can be combined with biomolecules to incorporate desired bioactivities to broaden their biomedical applications. In this review, we comprehensively summarized the synthesis, structures, and properties of biodegradable thermoplastic PUs, and introduced their multiple applications in tissue repair and regeneration. A whole picture of their design and applications along with discussions and perspectives of future directions would provide theoretical and technical supports to inspire new PU development and novel applications.

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  • Some synthetic biodegradable polymers have attracted considerable attention because they present high biocompatibility, ease of processing, and tailored mechanical properties and degradation rates.

    “some synthetic biodegradable polymers have attracted considerable attention over the past decades since the present high biocompatibility, ease of processing, as well as tailored mechanical properties and degradation rates [21][22][23][24][25][26]”

    From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [22]

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Authors
Xu, C., & Hong, Y.
Affiliations
The University of Texas at Arlington (US)
Corresponding author
Hong, Yi
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2022-09
Volume
15
Pages
250-271
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2021.11.029
PMC
PMC8940769
OpenAlex
W4205516814
Cited by
109
References
12
Citations by year
2026: 16 · 2025: 32 · 2024: 23 · 2023: 21 · 2022: 17
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Foundation (1554835)
  • National Institutes of Health (R01HD097330, R15HL140503, R21HD090680)
  • American Heart Association Inc (14BGIA20510066)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
tissue repair, tissue regeneration, scaffold materials, diisocyanates, diols, chain extenders, block copolymer synthesis, soft tissue mimics

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