Nitric oxide‐releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion
Abstract
Thrombosis and intimal hyperplasia are the principal causes of small‐diameter vascular graft failure. To improve the long‐term patency of polyurethane vascular grafts, we have incorporated both poly(ethylene glycol) and a diazeniumdiolate nitric oxide (NO) donor into the backbone of polyurethane to improve thromboresistance. Additionally, we have incorporated the laminin‐derived cell adhesive peptide sequence YIGSR to encourage endothelial cell adhesion and migration, while NO release encourages endothelial cell proliferation. NO production by polyurethane films under physiological conditions demonstrated biphasic release, in which an initial burst of 70% of the incorporated NO was released within 2 days, followed by sustained release over 2 months. Endothelial cell proliferation in the presence of the NO‐releasing material was increased as compared to control polyurethane, and platelet adhesion to polyethylene glycol‐containing polyurethane was decreased significantly with the addition of the NO donor. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008
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Endothelialization can alleviate thrombosis and intimal hyperplasia complications that cause small diameter vascular graft failure without systemic anticoagulants.
“The West115 and Wang114 groups both reported that NO releasing/generating grafts encourage endothelialization/endothelial cell proliferation, which can alleviate the complications of thrombosis and intimal hyperplasia (IH) that cause the failure of small diameter vascular grafts without the use of systemic anticoagulants.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [115]
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- Authors
- Taite, L. J., Yang, P., Jun, H., & West, J. L.
- Affiliations
- Rice University (US)
- Corresponding author
- West, Jennifer L.
- Venue
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Publisher
- Wiley
- Published
- 2007-05-11
- Volume
- 84B
- Issue
- 1
- Pages
- 108-116
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W2121495120
- Cited by
- 136
- References
- 64
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 10
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- nitric oxide donors, diazeniumdiolates, polyurethane vascular grafts, polyethylene glycol, YIGSR peptide, endothelialization, platelet adhesion, thromboresistance, intimal hyperplasia, graft patency, endothelial cell proliferation, small-diameter vascular grafts
- MeSH terms
- Animals, Biocompatible Materials, Blood Vessel Prosthesis, Cattle, Cell Adhesion, Endothelium, Vascular, Kinetics, Nitric Oxide, Magnetic Resonance Spectroscopy, Oligopeptides, Platelet Adhesiveness, Polyethylene Glycols, Polyurethanes, Rats, Sprague-Dawley, Nitric Oxide Donors, Cell Proliferation, Rats
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