The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes
Open accessAbstract
Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge. Here, a polydopamine-mediated graphene oxide (PGO) and hydroxyapatite nanoparticle (PHA)-incorporated conductive alginate/gelatin (AG) scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory microenvironment. PHA confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the scaffold. The conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+ channels. Moreover, the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species (ROS)-scavenging ability and anti-inflammatory activity. It also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in macrophages. The scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive, ROS-scavenging, anti-inflammatory, and immunomodulatory abilities. This study provides fundamental insights into the synergistical effects of conductivity, osteoinductivity, and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration.
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Citations
Cites
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BackgroundPromoting tissue regeneration by modulating the immune system
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Cited by
Wu, M., Liu, H., Zhu, Y., Wu, P., Chen, Y., Deng, Z., Zhu, X., & Cai, L. (2024) · Theranostics · doi:10.7150/thno.97335 · Cited by 189
Dopamine-based high-transparent hydrogel as bioadhesive for sutureless ocular tissue repair
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Self-citationWu, M., Chen, F., Liu, H., Wu, P., Yang, Z., Zhang, Z., Su, J., Cai, L., & Zhang, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100458 · Cited by 55
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Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials
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Metadata
- Authors
- Li, Y., Yang, L., Hou, Y., Zhang, Z., Chen, M., Wang, M., Liu, J., Wang, J., Zhao, Z., Xie, C., & Lu, X.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 18
- Pages
- 213-227
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W4221126722
- Cited by
- 280
- References
- 54
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Y., Yang, L., Hou, Y., Zhang, Z., Chen, M., Wang, M., Liu, J., Wang, J., Zhao, Z., Xie, C., & Lu, X. (2022). Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2022.03.021
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