The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment
Abstract
Poor O 2 supply to the infiltrated immune cells in the joint synovium of rheumatoid arthritis (RA) up-regulates hypoxia-inducible factor (HIF-1α) expression and induces reactive oxygen species (ROS) generation, both of which exacerbate synovial inflammation. Synovial inflammation in RA can be resolved by eliminating pro-inflammatory M1 macrophages and inducing anti-inflammatory M2 macrophages. Because hypoxia and ROS in the RA synovium play a crucial role in the induction of M1 macrophages and reduction of M2 macrophages, herein, we develop manganese ferrite and ceria nanoparticle-anchored mesoporous silica nanoparticles (MFC-MSNs) that can synergistically scavenge ROS and produce O 2 for reducing M1 macrophage levels and inducing M2 macrophages for RA treatment. MFC-MSNs exhibit a synergistic effect on O 2 generation and ROS scavenging that is attributed to the complementary reaction of ceria nanoparticles (NPs) that can scavenge intermediate hydroxyl radicals generated by manganese ferrite NPs in the process of O 2 generation during the Fenton reaction, leading to the efficient polarization of M1 to M2 macrophages both in vitro and in vivo . Intra-articular administration of MFC-MSNs to rat RA models alleviated hypoxia, inflammation, and pathological features in the joint. Furthermore, MSNs were used as a drug-delivery vehicle, releasing the anti-rheumatic drug methotrexate in a sustained manner to augment the therapeutic effect of MFC-MSNs. This study highlights the therapeutic potential of MFC-MSNs that simultaneously generate O 2 and scavenge ROS, subsequently driving inflammatory macrophages to the anti-inflammatory subtype for RA treatment.
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Metadata
- Authors
- Kim, J., Kim, H. Y., Song, S. Y., Go, S.-H., Sohn, H. S., Baik, S., Soh, M., Kim, K., Kim, D., Kim, H.-C., Lee, N., Kim, B.-S., & Hyeon, T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-04
- Volume
- 13
- Issue
- 3
- Pages
- 3206-3217
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2920324197
- Cited by
- 550
- References
- 10
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, J., Kim, H. Y., Song, S. Y., Go, S.-H., Sohn, H. S., Baik, S., Soh, M., Kim, K., Kim, D., Kim, H.-C., Lee, N., Kim, B.-S., & Hyeon, T. (2019). Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment. ACS Nano. https://doi.org/10.1021/acsnano.8b08785
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