Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

Petiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168

4 Histology and Histopathology

(2015) · Thieme eBooks · doi:10.1055/b-0035-108581 · Cited by 1,052

Reconstitution of γ-secretase activity

Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., & Haass, C. (2003) · Nature Cell Biology · doi:10.1038/ncb960 · Cited by 914

Autophagosome Formation in Mammalian Cells.

Mizushima, N., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function · doi:10.1247/csf.27.421 · Cited by 897

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Koo, E. H., & Squazzo, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32449-3 · Cited by 829

Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model system

Ewald, C. Y., & Li, C. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0235-3 · Cited by 67

Autophagy in Dementias

Kragh, C. L., Ubhi, K. K., Wyss‐Coray, T., & Masliah, E. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00545.x · Cited by 66

ERβ promotes Aβ degradation via the modulation of autophagy

Wei, Y. Q., Zhou, J., Wu, J., & Huang, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1786-8 · Cited by 67

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

Correia, S. C., Resende, R., Moreira, P. I., & Pereira, C. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2757 · Cited by 66

It’s a Cell-Eat-Cell World

Oczypok, E. A., Oury, T. D., & Chu, C. T. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.017 · Cited by 65

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

Soura, V., Stewart-Parker, M., Williams, T. L., Ratnayaka, J. A., Atherton, J., Gorringe, K., Tuffin, J. P., Darwent, E., Rambaran, R. N., Klein, W. L., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110749 · Cited by 62

Effect of Cholesterol Reduction on Receptor Signaling in Neurons

Fukui, K., Ferris, H. A., & Kahn, C. R. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.664367 · Cited by 65

Amyloid-β-Induced Mitochondrial Dysfunction Impairs the Autophagic Lysosomal Pathway in a Tubulin Dependent Pathway

Silva, D. F., Esteves, A. R., Arduíno, D. M., Oliveira, C. R., & Cardoso, S. M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110423 · Cited by 61

Herpes simplex virus type 1 and Alzheimer's disease: The autophagy connection

Itzhaki, R. F., Cosby, S. L., & Wozniak, M. A. (2008) · Journal of NeuroVirology · doi:10.1080/13550280701802543 · Cited by 61

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy

Fan, S., Zhang, B., Luan, P., Gu, B., Wan, Q., Huang, X., Liao, W., & Liu, J. (2015) · BioMed Research International · doi:10.1155/2015/161020 · Cited by 61

Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells

Xue, Z., Guo, Y., Zhang, S., Huang, L., He, Y., Fang, R., & Fang, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.08.006 · Cited by 60

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease

Song, W.-J., Son, M.-Y., Lee, H.-W., Seo, H., Kim, J. H., & Chung, S.-H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136950 · Cited by 50

Genetics of Late‐Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared Pathways

Olgiati, P., Politis, A. M., Papadimitriou, G. N., Ronchi, D. D., & Serretti, A. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/832379 · Cited by 58

Presenilin/γ‐secretase activity regulates protein clearance from the endocytic recycling compartment

Zhang, M., Haapasalo, A., Kim, D. Y., Ingano, L. A. M., Pettingell, W. H., & Kovacs, D. M. (2006) · The FASEB Journal · doi:10.1096/fj.05-5531fje · Cited by 58

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

Magnaudeix, A., Wilson, C. M., Page, G., Bauvy, C., Codogno, P., Lévêque, P., Labrousse, F., Delage-Corre, M., Yardin, C., & Terro, F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.026 · Cited by 57

Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy

Piras, A., Schiaffino, L., Boido, M., Valsecchi, V., Guglielmotto, M., Amicis, E. D., Puyal, J., Garcerá, A., Tamagno, E., Soler, R. M., et al. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0086-4 · Cited by 60

The Role of Autophagy in the Correlation Between Neuron Damage and Cognitive Impairment in Rat Chronic Cerebral Hypoperfusion

Zou, W., Song, Y., Li, Y., Du, Y., Zhang, X., & Fu, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0351-z · Cited by 54

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

Guo, J., Cheng, J., North, B. J., & Wei, W. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.07.001 · Cited by 55

Stressed mitochondria: A target to intrude alzheimer’s disease

Sharma, V., Singh, T. G., & Mehta, V. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.004 · Cited by 53

Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer's disease

Li, H., Zheng, T., Lian, F., Xu, T., Yin, W., & Jiang, Y. (2021) · Nutrition · doi:10.1016/j.nut.2021.111473 · Cited by 54

Autophagosomes accumulation is associated with β‐amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats

Zhang, J., Zhang, Y., Li, J., Xing, S., Li, C., Li, Y., Dang, C., Fan, Y., Yu, J., Pei, Z., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07496.x · Cited by 51

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

Furusawa, K., Takasugi, T., Chiu, Y., Hori, Y., Tomita, T., Fukuda, M., & Hisanaga, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005385 · Cited by 53

Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders

Lee, C.-H., & Hung, S.-Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010031 · Cited by 50

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Tong, B. C.-K., Wu, A. J., Huang, A. S., Dong, R., Malampati, S., Iyaswamy, A., Krishnamoorthi, S., Sreenivasmurthy, S. G., Zhu, Z., Su, C., et al. (2022) · Autophagy · doi:10.1080/15548627.2021.1945220 · Cited by 49

Alzheimer's disease genes and autophagy

Yoon, S.-Y., & Kim, D.-H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.018 · Cited by 42

Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway

Yu, Q., Cheng, X., Gong, G., Yan, T., Du, Y., Wu, B., Bi, K., & Jia, Y. (2020) · Food & Function · doi:10.1039/c9fo02927c · Cited by 48

Amino acid starvation induced autophagic cell death in PC-12 cells: Evidence for activation of caspase-3 but not calpain-1

Sadasivan, S., Waghray, A., Larner, S. F., Dunn, W. A., Hayes, R. L., & Wang, K. (2006) · APOPTOSIS · doi:10.1007/s10495-006-7690-6 · Cited by 47

Compromised autophagy and mitophagy in brain ageing and Alzheimer’s diseases.

Caponio, D., Veverová, K., Zhang, S.-Q., Shi, L., Wong, G., Vyhnalek, M., & Fang, E. F. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100056 · Cited by 45

Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones

Mbah, N. E., Overmeyer, J. H., & Maltese, W. A. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9369-2 · Cited by 45

Autophagy in Alzheimer’s disease

Moreira, P. I., Santos, R. X., Zhu, X., Lee, H.-G., Smith, M. A., Casadesus, G., & Perry, G. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.84 · Cited by 55

Mechanisms of Mitochondrial Malfunction in Alzheimer’s Disease: New Therapeutic Hope

Nabi, S. U., Khan, A., Siddiqui, E. M., Rehman, M. U., Alshahrani, S., Arafah, A. M., Mehan, S., Alsaffar, R. M., Alexiou, A. T., & Shen, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4759963 · Cited by 51

Parkinsons Disease: Genetics and Beyond

Inamdar, N., Arulmozhi, D. K., Tandon, A., & Bodhankar, S. L. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866893 · Cited by 46

Lysosomal LAMP 1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K. J., Carosi, J. M., Kamei, M., & Sargeant, T. J. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13913 · Cited by 44

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology

Suelves, N., Saleki, S., Ibrahim, T., Palomares, D., Moonen, S., Koper, M. J., Vrancx, C., Vadukul, D. M., Papadopoulos, N., Viceconte, N., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01578-x · Cited by 43

The NF-κB Factor Relish Regulates Atg1 Expression and Controls Autophagy

Nandy, A., Lin, L., Velentzas, P. D., Wu, L. P., Baehrecke, E. H., & Silverman, N. S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.076 · Cited by 43

Lost in traffic: consequences of altered palmitoylation in neurodegeneration

Ramzan, F., Abrar, F., Mishra, G. G., Liao, L. M. Q., & Martin, D. D. O. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1166125 · Cited by 43

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

Tang, W., Tam, J. H. K., Seah, C., Chiu, J., Tyrer, A. E., Cregan, S. P., Meakin, S. O., & Pasternak, S. (2015) · Molecular Brain · doi:10.1186/s13041-015-0129-7 · Cited by 42

Experimental Evidence of the Benefits of Acupuncture for Alzheimer's Disease: An Updated Review

Yu, C.-C., Du, Y., Wang, S., Liu, L.-B., Shen, F., Wang, L., Lin, Y.-F., & Kong, L.-H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.549772 · Cited by 43

Development and Translation of NanoBEO, a Nanotechnology-Based Delivery System of Bergamot Essential Oil Deprived of Furocumarins, in the Control of Agitation in Severe Dementia

Scuteri, D., Cassano, R., Trombino, S., Russo, R., Mizoguchi, H., Watanabe, C., Hamamura, K., Katsuyama, S., Komatsu, T., Morrone, L. A., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030379 · Cited by 41

BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Marks, N., & Berg, M. J. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0054-1 · Cited by 38

Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease

Yoon, S. Y., Choi, J. E., Kweon, H., Choe, H., Kim, S. W., Hwang, O., Lee, H., Lee, J., & Kim, D. H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21760 · Cited by 40

Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

Galván, V., & Hart, M. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.010 · Cited by 41

Intracellular Amyloid β-Protein As a Therapeutic Target for Treating Alzheimers Disease

Ohyagi, Y. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898514 · Cited by 42

LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice

Hung, S., Huang, W., Liou, H., & Fu, W. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.003 · Cited by 39

Proteasome function is required to maintain muscle cellular architecture.

Haas, K. F., Woodruff, E., & Broadie, K. (2007) · Biology of the Cell · doi:10.1042/bc20070019 · Cited by 38

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

Zhang, T., Yan, W., Li, Q., Fu, J., Liu, K., Jia, W., Sun, X., & Liu, X. (2011) · Neurological Research · doi:10.1179/1743132810y.0000000006 · Cited by 38

New Insights Into Autophagy Dysfunction Related to Amyloid Beta Toxicity and Neuropathology in Alzheimer's Disease

Ntsapi, C., Lumkwana, D., Swart, C., du Toit, A., & Loos, B. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.002 · Cited by 39

Intracellular Amyloid Precursor Protein Sorting and Amyloid- Secretion Are Regulated by Src-Mediated Phosphorylation of Mint2

Chaufty, J., Sullivan, S. E., & Ho, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0602-12.2012 · Cited by 43

Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease

Krishnan, S., Shrestha, Y., Jayatunga, D. P. W., Rea, S. L., Martins, R. N., & Bharadwaj, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186739 · Cited by 38

Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons

Song, L., Yao, L., Zhang, L., Piao, Z., & Lu, Y. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01792-2 · Cited by 36

Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway

Malnar, M., Košiček, M., Mitterreiter, S., Omerbašić, D., Lichtenthaler, S. F., Goate, A., & Hecimovic, S. K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.05.006 · Cited by 36

Lipid droplets and autophagy—links and regulations from yeast to humans

Schepers, J., & Behl, C. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29889 · Cited by 34

Neurons die with heightened but functional macro- and chaperone mediated autophagy upon increased amyloid-ß induced toxicity with region-specific protection in prolonged intermittent fasting

Ntsapi, C., & Loos, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112840 · Cited by 35

Beyond Amyloid

Lane, R. F., Shineman, D. W., Steele, J., Lee, L. H., & Fillit, H. M. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-394816-8.00007-6 · Cited by 35

Advances with RNA interference in Alzheimer’s disease research

Yuan, W., Chen, S., Ge, X., Chen, Y., Lu, N., & Liu, Z. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s40229 · Cited by 38

11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model

Puigoriol‐Illamola, D., Griñán‐Ferré, C., Vasilopoulou, F., Leiva, R., Vázquez, S., & Pallàs, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1026-8 · Cited by 36

Regulation of Aβ pathology by beclin 1: a protective role for autophagy?

Lee, J., & Gao, F. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35662 · Cited by 33

Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer’s Disease through AMPK-mTOR Signaling in the APP Swe /PS1 dE9 Mouse Model

Liu, H., Qiu, H., Xiao, Q., & Le, W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150303 · Cited by 32

Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration

Hussain, M. S., Agrawal, N., Ilma, B., Rekha, M. M., Nayak, P. P., Kaur, M., Khachi, A., Goyal, K., Rekha, A., Gupta, S., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70503 · Cited by 35

Regulation of autophagic flux by CHIP

Guo, D., Ying, Z., Wang, H., Chen, D., Gao, F., Ren, H., & Wang, G. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1543-7 · Cited by 31

Upexpression of Beclin-1-Dependent Autophagy Protects Against Beta-amyloid-Induced Cell Injury in PC12 Cells

Xue, Z., Zhang, S., Huang, L., He, Y., Fang, R., & Fang, Y. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9974-y · Cited by 31

Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy

Wu, H., Lu, M., Wang, W., Zhang, M., Zhu, Q.-Q., Xia, Y., Xu, R., Yang, Y., Chen, L., & Ma, Q. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143162 · Cited by 31

Autophagy and amino acid metabolism in the brain: implications for epilepsy

Bejarano, E., & Rodríguez‐Navarro, J. A. (2014) · Amino Acids · doi:10.1007/s00726-014-1822-z · Cited by 31

Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine

Fei, X., Qin, Z., Xiang, B., Li, L., Han, F., Fukunaga, K., & Liang, Z. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.057 · Cited by 30

Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

Marks, N., & Berg, M. J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.020 · Cited by 30

Autophagy in Disease Onset and Progression

Wang, H., Li, X., Zhang, Q., Fu, C., Jiang, W., Xue, J., Liu, S., Meng, Q., Ai, L., Zhi, X., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0815 · Cited by 29

Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer's disease via regulating autophagy

Gu, H., Li, L., Cui, C., Zhao, Z., & Song, G. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4977 · Cited by 28

Intramembrane proteolysis within lysosomes

Schröder, B., & Säftig, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.012 · Cited by 28

Autophagy system as a potential therapeutic target for neurodegenerative diseases

Cui, M., Yoshimori, T., & Nakamura, S. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105308 · Cited by 29

Exacerbation of ischemia-induced amyloid-β generation by diabetes is associated with autophagy activation in mice brain

Zhang, T., Liu, X., Li, Q., Wang, J., Jia, W., & Sun, X. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.064 · Cited by 28

Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ1–42-Injected Rats

Jiang, X., Chen, L.-L., Lan, Z., Xiong, F., Xu, X., Yin, Y.-Y., Li, P., & Wang, P. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02889-z · Cited by 28

BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β

Saha, A. D., Saleem, S., Paidi, R. K., & Biswas, S. C. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00748-x · Cited by 27

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

Harris, M., Hindy, M. E., Moraes, M. U., Hudd, F., Shafei, M. A., Dong, M., Hezwani, M., Clark, P., House, M., Forshaw, T. E., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.019 · Cited by 28

Activation of transient receptor potential melastatin 7 (TRPM7) channel increases basal autophagy and reduces amyloid β-peptide

Oh, H. G., & Chung, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.163 · Cited by 25

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

Feleciano, D. R., Juenemann, K., Iburg, M., Brás, I. C., Holmberg, C. I., & Kirstein, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00009 · Cited by 27

The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity

Renziehausen, J., Hiebel, C., Nagel, H., Kundu, A., Kins, S., Kögel, D., Behl, C., & Hajieva, P. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-140600 · Cited by 25

A neuronal aging pattern unique to humans and common chimpanzees

Gilissen, E., Leroy, K., Yilmaz, Z., Kövari, E., Bouras, C., Boom, A., Poncelet, L., ERWIN, J. M., Sherwood, C. C., Hof, P. R., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0931-5 · Cited by 26

UsingDrosophilaModels of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer’s Disease

O’Keefe, L. V., & Denton, D. (2018) · BioMed Research International · doi:10.1155/2018/5195416 · Cited by 25

Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus

Park, K. A., Lee, J. Y., Han, H. M., An, H. S., Jin, Z. H., Jeong, E. A., Kim, K. E., Shin, H. J., Lee, J., Kang, D., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03723-7 · Cited by 27

The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis

Kim, Y., Kim, C., Son, S. M., Song, H., Hong, H., Han, S.-H., & Mook‐Jung, I. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0068-5 · Cited by 25

Proteostasis and Ribostasis Impairment as Common Cell Death Mechanisms in Neurodegenerative Diseases

Lim, S. M., Nahm, M., & Kim, S. H. (2023) · Journal of Clinical Neurology · doi:10.3988/jcn.2022.0379 · Cited by 24

Immortalized Alzheimer’s Disease Astrocytes: Characterization of Their Proteolytic Systems

Gong, C., Bonfili, L., Zheng, Y., Cecarini, V., Cuccioloni, M., Angeletti, M., Dematteis, G., Tapella, L., Genazzani, A. A., Lim, D., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03231-z · Cited by 22

β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

Piedrahita, D., Castro-Álvarez, J. F., Boudreau, R. L., Villegas‐Lanau, A., Kosik, K. S., Gallego-Gómez, J. C., & Cardona‐Gómez, G. P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00498 · Cited by 25

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Zhong, C., Shu, M., Ye, J., Wang, X., Chen, X., Liu, Z., Zhao, W., Zhao, B., Zheng, Z., Yin, Z., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5643-z · Cited by 22

The fine-tuning of proteolytic pathways in Alzheimer’s disease

Cecarini, V., Bonfili, L., Cuccioloni, M., Mozzicafreddo, M., Angeletti, M., Keller, J. N., & Eleuteri, A. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2238-6 · Cited by 21

The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease

Torres, M., Marcilla-Etxenike, A., Fiol-deRoque, M. A., Escribá, P. V., & Busquets, X. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1099-z · Cited by 19

Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases

Victoria, G. S., & Zurzolo, C. (2015) · Virus Research · doi:10.1016/j.virusres.2015.01.019 · Cited by 20

A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways

Vegh, C., Stokes, K., Ma, D., Wear, D., Cohen, J. S., Ray, S. D., & Pandey, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181230 · Cited by 19

CHIP modulates APP‐induced autophagy‐dependent pathological symptoms in Drosophila

Zhuang, L., Peng, F., Huang, Y., Li, W., Huang, J., Chu, Y., Ren, P., Sun, Y., Zhang, Y., Xue, E., et al. (2019) · Aging Cell · doi:10.1111/acel.13070 · Cited by 19

BACE1 Expression and Activity: Relevance in Alzheimer’s Disease

Zacchetti, D., Chieregatti, E., Bettegazzi, B., Mihailovich, M., Sousa, V. L., Grohovaz, F., & Meldolesi, J. (2007) · Neurodegenerative Diseases · doi:10.1159/000101836 · Cited by 19

A Butyrolactone Derivative 3BDO Alleviates Memory Deficits and Reduces Amyloid-β Deposition in an AβPP/PS1 Transgenic Mouse Model

Wei, L., Yang, H., Xie, Z., Yang, S., Yang, H., Zhao, C., Wang, P., Xu, S., Miao, J., Zhao, B., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111985 · Cited by 17

Protein Quality Control in Neurodegeneration: Walking the Tight Rope Between Health and Disease

Hol, E. M., & Scheper, W. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0013-8 · Cited by 19

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

Komura, H., Kakio, S., Sasahara, T., Arai, Y., Takino, N., Sato, M., Satomura, K., Ohnishi, T., Nabeshima, Y.-I., Muramatsu, S., et al. (2019) · iScience · doi:10.1016/j.isci.2019.01.018 · Cited by 18

Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation

Gereñu, G., Persson, T., Goikolea, J., Calvo‐Garrido, J., Loera‐Valencia, R., Pottmeier, P., Santiago, C. A., Poska, H., Presto, J., & Cedazo-Mı́nguez, Á. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0521-2 · Cited by 18

Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by Aβ in rats

Mohammadi, M., Guan, J., Khodagholi, F., Yans, A., Khalaj, S., Gholami, M., Taghizadeh, G., Aliaghaei, A., Abdollahi, M. R., Ghahremani, M., et al. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1222-x · Cited by 18

Lysosomal Dysregulation in the Murine App Model of Alzheimer’s Disease

Whyte, L. S., Hassiotis, S., Hattersley, K. J., Hemsley, K. M., Hopwood, J. J., Lau, A. A., & Sargeant, T. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.042 · Cited by 19

Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy

Liu, W., Fu, R., Wang, Z., Liu, S., Tang, C., Li, L., & Yin, D. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz106 · Cited by 17

Enhanced autophagy signaling in diabetic rats with ischemia-induced seizures

Xia, L., Lei, Z., Shi, Z., Guo, D., Su, H. H. M., Ruan, Y., & Xu, Z. C. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.054 · Cited by 17

Autophagy modulates Aβ accumulation and formation of aggregates in yeast

Bharadwaj, P. R., & Martins, R. N. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103466 · Cited by 17

Tetrahydroxy Stilbene Glucoside improved the behavioral disorders of APP695V717I transgenic mice by inhibiting the expression of Beclin-1 and LC3-II

Hong-bo, L., Yun, L., Jiankui, G., Zunjing, L., Zhiqiang, Z., Yong, W., Zhao, L., & Xiangqun, S. (2015) · 中医杂志：英文版 · doi:10.1016/s0254-6272(15)30100-x · Cited by 17

Aβ generation in autophagic vacuoles

Mizushima, N. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200508097 · Cited by 45

Cellular trafficking and metabolism of the Alzheimer's disease amyloid precursor protein (APP) in the secretory and endocytic pathways.

Steinhilb, M. L. (2002) · Deep Blue (University of Michigan)

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies

Hermey, G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.170288 · Cited by 1

Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation

Beher, D., Li, Y., Gardell, S. J., & Shearman, M. S. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)82183-1

Losing connections in Alzheimer disease : the amyloid precursor protein processing machinery at the synapse

Lundgren, J. L. (2018) · Figshare