Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

Petiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168

4 Histology and Histopathology

(2015) · Thieme eBooks · doi:10.1055/b-0035-108581 · Cited by 1,052

Reconstitution of γ-secretase activity

Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., & Haass, C. (2003) · Nature Cell Biology · doi:10.1038/ncb960 · Cited by 914

Autophagosome Formation in Mammalian Cells.

Mizushima, N., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function · doi:10.1247/csf.27.421 · Cited by 897

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Koo, E. H., & Squazzo, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32449-3 · Cited by 829

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., García-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,789

Autophagy in cell death: an innocent convict?

Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 268

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Moreira, P. I., Carvalho, C., Zhu, X., Smith, M. A., & Perry, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.006 · Cited by 734

Autophagy: A lysosomal degradation pathway with a central role in health and disease

Eskelinen, E., & Säftig, P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.014 · Cited by 716

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 698

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749

Oxidative Stress and Autophagy

Kiffin, R., Bandyopadhyay, U., & Cuervo, A. M. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.152 · Cited by 529

Autophagy: Basic Principles and Relevance to Disease

Kundu, M., & Thompson, C. B. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.091842 · Cited by 523

The different autophagy degradation pathways and neurodegeneration

Fleming, A., Bourdenx, M., Fujimaki, M., Karabiyik, C., Krause, G. J., Lopez, A., Martín‐Segura, A., Puri, C., Scrivo, A., Skidmore, J., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.017 · Cited by 500

Regulation of Autophagy by Extracellular Signal-Regulated Protein Kinases During 1-Methyl-4-Phenylpyridinium-Induced Cell Death

Zhu, J.-H., Horbinski, C., Guo, F., Watkins, S. C., Uchiyama, Y., & Chu, C. T. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060524 · Cited by 447

Does Autophagy Contribute To Cell Death?

Debnath, J., Baehrecke, E. H., & Kroemer, G. (2005) · Autophagy · doi:10.4161/auto.1.2.1738 · Cited by 451

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

Gowrishankar, S., Yuan, P., Wu, Y., Schrag, M., Paradise, S., Grutzendler, J., De Camilli, P., & Ferguson, S. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510329112 · Cited by 406

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Nixon, R. A., & Rubinsztein, D. C. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00757-5 · Cited by 435

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

Pajares, M., Jiménez-Moreno, N., García-Yagüe, Á. J., Escoll, M., de Ceballos, M. L., Van Leuven, F., Rábano, A., Yamamoto, M., Rojo, A. I., & Cuadrado, A. (2016) · Autophagy · doi:10.1080/15548627.2016.1208889 · Cited by 392

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia

Zhu, C., Wang, X., Xu, F., Bahr, B. A., Shibata, M., Uchiyama, Y., Hagberg, H., & Blomgren, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401545 · Cited by 403

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

Nixon, R. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.018 · Cited by 380

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J. O., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.002 · Cited by 371

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

Gorman, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00402.x · Cited by 362

Regulation of presynaptic neurotransmission by macroautophagy

Hernandez, D., Torres, C. A., Setlik, W., Cebrián, C., Mosharov, E., Tang, G.-M., Cheng, H.-C., Kholodilov, N., Yarygina, O., Burke, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.020 · Cited by 346

Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61253-9 · Cited by 330

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

Sun, X., Chen, W., & Wang, Y. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00221 · Cited by 340

Chaperone-mediated autophagy in aging and disease

Massey, A. C., Zhang, C., & Cuervo, A. M. (2006) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73007-6 · Cited by 315

Autophagy in neurodegenerative disease: friend, foe or turncoat?

Nixon, R. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.003 · Cited by 321

Insulin‐like growth factor‐1 and TNF‐α regulate autophagy through c‐jun N‐terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells

Jia, G., Cheng, G., Gangahar, D. M., & Agrawal, D. K. (2006) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2006.01454.x · Cited by 306

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

Rodríguez-Navarro, J. A., Rodríguez, L., Casarejos, M. J., Solano, R. M., Gómez, A., Perucho, J., Cuervo, A. M., García de Yébenes, J., & Mena, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.014 · Cited by 298

Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia–ischaemia

Zhu, C., Xu, F., Wang, X., Shibata, M., Uchiyama, Y., Blomgren, K., & Hagberg, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03639.x · Cited by 273

Substrate specificity of γ-secretase and other intramembrane proteases

Beel, A. J., & Sanders, C. R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7462-2 · Cited by 274

The biological pathways of Alzheimer disease: a review

Calabrò, M., Rinaldi, C., Santoro, G., & Crisafulli, C. (2020) · AIMS neuroscience · doi:10.3934/neuroscience.2021005 · Cited by 287

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

Piras, A., Collin, L., Grüninger, F., Graff, C., & Rönnbäck, A. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0292-9 · Cited by 271

Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis

Cao, Y., Espinola, J. A., Fossale, E., Massey, A. C., Cuervo, A. M., MacDonald, M. E., & Cotman, S. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602180200 · Cited by 254

The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

Guglielmotto, M., Aragno, M., Autelli, R., Giliberto, L., Novo, E., Colombatto, S., Danni, O., Parola, M., Smith, M. A., Perry, G. L., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05858.x · Cited by 245

Infectious Agents and Neurodegeneration

Chiara, G. D., Marcocci, M. E., Sgarbanti, R., Civitelli, L., Ripoli, C., Piacentini, R., Garaci, E., Grassi, C., & Palamara, A. T. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8320-7 · Cited by 232

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

Sanchez-Varo, R., Trujillo-Estrada, L., Sanchez-Mejias, E., Torres, M., Baglietto-Vargas, D., Moreno-Gonzalez, I., De Castro, V., Jimenez, S., Ruano, D., Vizuete, M., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0896-x · Cited by 222

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

Li, L., Zhang, X., Yang, D., Luo, G., Chen, S., & Le, W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.011 · Cited by 220

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

Stavoe, A. K. H., Kargbo-Hill, S. E., Hall, D. H., & Colón-Ramos, D. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.012 · Cited by 211

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

HNRC, Achim, C. L., Adame, A., Dumaop, W., Everall, I. P., & Masliah, E. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9152-8 · Cited by 205

Autophagy in Alzheimer’s disease

Zare-shahabadi, A., Masliah, E., Johnson, G. V. W., & Rezaei, N. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0076 · Cited by 204

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

Martín-Maestro, P., Gargini, R., Perry, G., Avila, J., & García-Escudero, V. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddv616 · Cited by 184

The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

Lauritzen, I., Pardossi-Piquard, R., Bauer, C., Brigham, E., Abraham, J.-D., Ranaldi, S., Fraser, P., St-George-Hyslop, P., Le Thuc, O., Espin, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2775-12.2012 · Cited by 201

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

Cataldo, A. M., Mathews, P. M., Boyer‐Boiteau, A., Hassinger, L. C., Peterhoff, C. M., Jiang, Y., Mullaney, K. A., Neve, R. L., Gruenberg, J. E., & Nixon, R. A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071053 · Cited by 188

Pathological apoptosis in the developing brain

Blomgren, K., Leist, M., & Groc, L. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0754-4 · Cited by 183

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

Gururaj Joshi, A., Gan, K. A., Johnson, D. A., & Johnson, J. A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.004 · Cited by 180

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

Bowles, K. R., Silva, M. C., Whitney, K., Bertucci, T., Berlind, J. E., Lai, J. D., Garza, J. C., Boles, N. C., Mahali, S., Strang, K. H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.003 · Cited by 175

The Function of Autophagy in Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125990 · Cited by 178

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-48 · Cited by 168

Autophagy in tumor suppression and cancer therapy

Kung, C.-P., Budina, A., Balaburski, G. M., Bergenstock, M., & Murphy, M. E. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.50 · Cited by 168

BACE Is Degraded via the Lysosomal Pathway

Koh, Y. H., Arnim, C. A. F. V., Hyman, B. T., Tanzi, R. E., & Tesco, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506199200 · Cited by 166

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B. C., & Ghavami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073330 · Cited by 158

Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology

Cataldo, A. M., Peterhoff, C. M., Schmidt, S. D., Terio, N. B., Duff, K., Beard, M. E., Mathews, P. M., & Nixon, R. A. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.8.821 · Cited by 157

Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction

Moreira, P. I., Santos, M. S., & Oliveira, C. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1703 · Cited by 155

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J., & Sargeant, T. J. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13935 · Cited by 150

Amyloid Precursor Protein and Notch Intracellular Domains are Generated after Transport of their Precursors to the Cell Surface

Kaether, C., Schmitt, S., Willem, M., & Haass, C. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00396.x · Cited by 152

Alzheimer’s disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Carvalho, C., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.001 · Cited by 145

Herpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within

Itzhaki, R. F., & Wozniak, M. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13405 · Cited by 143

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner

Neely, K. M., Green, K. N., & LaFerla, F. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5156-10.2010 · Cited by 134

Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease

Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20161 · Cited by 139

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

Cai, Z., Zhao, B., Li, K., Zhang, L., Li, C., Quazi, S. H., & Tan, Y. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23011 · Cited by 134

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

Santana, S., Recuero, M., Bullido, M. J., Valdivieso, F., & Aldudo, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.12.010 · Cited by 131

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

Tizón, B., Sahoo, S., Yu, W. H., Gauthier, S. A., Kumar, A. R., Mohan, P. S., Figliola, M. J., Pawlik, M., GRUBB, A. O., Uchiyama, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009819 · Cited by 123

and Alzheimer's disease

Brioni, J. D., Esbenshade, T. A., Garrison, T. R., Bitner, S. R., & Cowart, M. (2010) · Cited by 125

Dual Role of Autophagy in Diseases of the Central Nervous System

Bar-Yosef, T., Damri, O., & Agam, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00196 · Cited by 128

Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of β-Amyloid Peptide inC. elegans

Florez‐McClure, M. L., Hohsfield, L. A., Fonte, G., Bealor, M. T., & Link, C. D. (2007) · Autophagy · doi:10.4161/auto.4776 · Cited by 130

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

García‐Escudero, V., Martín-Maestro, P., Perry, G. L., & Ávila, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/162152 · Cited by 120

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

Zhang, X., Heng, X., Li, T., Li, L., Yang, D., Zhang, X., Du, Y., Doody, R. S., & Le, W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101875 · Cited by 120

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

François, A., Terro, F., Janet, T., Bilan, A. R., Paccalin, M., & Page, G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-151 · Cited by 92

Autophagy: A double-edged sword in Alzheimer’s disease

Tung, Y.-T., Wang, B., Hu, M., Hsu, W., Lee, H., Huang, W., & Liao, Y. (2012) · Journal of Biosciences · doi:10.1007/s12038-011-9176-0 · Cited by 105

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Torres, M., Jiménez, S., Sanchez-Varo, R. M., Navarro, V., Trujillo‐Estrada, L., Sánchez‐Mejías, E., Carmona, I., Dávila, J. C., Vizuete, M., Gutiérrez, A., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-59 · Cited by 103

Autophagy core machinery: overcoming spatial barriers in neurons

Ariosa, A., & Klionsky, D. J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1461-9 · Cited by 108

Mechanisms of amyloid plaque pathogenesis

Fiala, J. C. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0284-8 · Cited by 99

Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from α-synuclein

Bandyopadhyay, U., & Cuervo, A. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.019 · Cited by 103

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

Asadi, F., Jamshidi, A. H., Khodagholi, F., Yans, A., Azimi, L., Faizi, M., Vali, L., Abdollahi, M. R., Ghahremani, M. H., & Sharifzadeh, M. S. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.10.011 · Cited by 95

YM155 down‐regulates survivin and XIAP , modulates autophagy and induces autophagy‐dependent DNA damage in breast cancer cells

Cheng, S. M., Chang, Y.-C., Liu, C. Y., Lee, J. Y. C., Chan, H.-H., Kuo, C.-W., Lin, K. Y., Tsai, S. L., Chen, S.-Y., Li, C., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12935 · Cited by 94

On the role of autophagy in human diseases: a gender perspective

Lista, P., Straface, E., Brunelleschi, S., Franconi, F., & Malorni, W. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01293.x · Cited by 95

Alterations in ROS Activity and Lysosomal pH Account for Distinct Patterns of Macroautophagy in LINCL and JNCL Fibroblasts

Vidal-Donet, J. M., Cárcel‐Trullols, J., Casanova, B., Aguado, C., & Knecht, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055526 · Cited by 91

Autophagic pathways and metabolic stress

Kaushik, S., Singh, R., & Cuervo, A. M. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01263.x · Cited by 95

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

Rout, A. K., Strub, M., Piszczek, G., & Tjandra, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609446 · Cited by 102

Rapamycin, Autophagy, and Alzheimer's Disease.

Cai, Z., & Yan, L. (2013) · PubMed · Cited by 97

Beclin 1 Complex in Autophagy and Alzheimer Disease

Jaeger, P. A., & Wyss‐Coray, T. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.258 · Cited by 93

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein

Gómez, W., Morales, R., Maracaja‐Coutinho, V., Parra, V., & Nassif, M. (2020) · Aging · doi:10.18632/aging.102677 · Cited by 94

Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer's Disease

Friedman, L. G., Qureshi, Y. H., & Yu, W. H. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0320-z · Cited by 89

Mitochondrial Abnormalities in Alzheimer’s Disease

Silva, D. F., Selfridge, J. E., Lu, J., E, L., Cardoso, S. M., & Swerdlow, R. H. (2012) · Advances in Pharmacology · doi:10.1016/b978-0-12-394816-8.00003-9 · Cited by 86

Autophagy Dysfunction in Alzheimer’s Disease

Li, L., Zhang, X., & Le, W. (2010) · Neurodegenerative Diseases · doi:10.1159/000276710 · Cited by 81

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

Zheng, L. P., Terman, A., Hallbeck, M., Dehvari, N., Cowburn, R. F., Benedikz, E., Kågedal, K., Cedazo-Mínguez, Á., & Marcusson, J. O. (2011) · Autophagy · doi:10.4161/auto.7.12.18051 · Cited by 81

Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome–lysosome fusion

Bustos, V., Pulina, M. V., Bispo, A., Lam, A. C., Flajolet, M., Gorelick, F. S., & Greengard, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705240114 · Cited by 80

Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death

Leong, Y. Q., Ng, K. Y., Chye, S. M., Ling, A. P. K., & Koh, R. Y. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00516-y · Cited by 80

Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease

Ma, J., Huang, Y. M., Chen, S., & Halliday, G. M. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01067.x · Cited by 77

SUMO1 promotes Aβ production via the modulation of autophagy

Cho, S., Yun, S., Jo, C., Lee, D., Choi, K. J., Song, J. C., Park, S. I., Kim, Y.-J., & Koh, Y. H. (2014) · Autophagy · doi:10.4161/15548627.2014.984283 · Cited by 76

How Parkinsonian Toxins Dysregulate the Autophagy Machinery

Dagda, R. K., Banerjee, T. D., & Janda, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122163 · Cited by 77

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

Tam, J. H. K., Seah, C., & Pasternak, S. (2014) · Molecular Brain · doi:10.1186/s13041-014-0054-1 · Cited by 83

Autophagy in Astrocytes and its Implications in Neurodegeneration

Sung, K., & Jiménez-Sánchez, M. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.041 · Cited by 78

Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

Tien, N. T., Karaca, I., Tamboli, I. Y., & Walter, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719286 · Cited by 71

Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation

Feng, T., Tammineni, P., Agrawal, C., Jeong, Y. Y., & Cai, Q. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.766584 · Cited by 69

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system

Zheng, L. P., Cedazo-Mı́nguez, Á., Hallbeck, M., Jerhammar, F., Marcusson, J. O., & Terman, A. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-19 · Cited by 73

Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand?

Lumkwana, D., du Toit, A., Kinnear, C. J., & Loos, B. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.006 · Cited by 69

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Keeling, E., Lotery, A. J., Tumbarello, D. A., & Ratnayaka, J. A. (2018) · Cells · doi:10.3390/cells7020016 · Cited by 72

Trehalose against Alzheimer's Disease: Insights into a Potential Therapy

Khalifeh, M., Read, M. I., Barreto, G. E., & Sahebkar, A. (2020) · BioEssays · doi:10.1002/bies.201900195 · Cited by 67

Amyloid and Alzheimer's Disease: Inside and Out

Tam, J. H. K., & Pasternak, S. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013408 · Cited by 64

Aβ generation in autophagic vacuoles

Mizushima, N. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200508097 · Cited by 45

Cellular trafficking and metabolism of the Alzheimer's disease amyloid precursor protein (APP) in the secretory and endocytic pathways.

Steinhilb, M. L. (2002) · Deep Blue (University of Michigan)

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies

Hermey, G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.170288 · Cited by 1

Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation

Beher, D., Li, Y., Gardell, S. J., & Shearman, M. S. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)82183-1

Losing connections in Alzheimer disease : the amyloid precursor protein processing machinery at the synapse

Lundgren, J. L. (2018) · Figshare