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Alzheimer's disease genes and autophagy

Yoon, Seung-Yong, Kim, Dong-Hou·2016·Brain Research
DOI 10.1016/j.brainres.2016.03.018
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Abstract

Autophagy is a process to degrade and recycle cellular constituents via the lysosome for regulating cellular homeostasis. Its dysfunction is now considered to be involved in many diseases, including neurodegenerative diseases. Many features reflecting autophagy impairment, such as autophagosome accumulation and lysosomal dysfunction, have been also revealed to be involved in Alzheimer's disease (AD). Recent genetic studies such as genome-wide association studies in AD have identified a number of novel genes associated with AD. Some of the identified genes have demonstrated dysfunction in autophagic processes in AD, while others remain under investigation. Since autophagy is strongly regarded to be one of the major pathogenic mechanisms of AD, it is necessary to review how the AD-associated genes are related to autophagy. We anticipate our current review to be a starting point for future studies regarding AD-associated genes and autophagy. This article is part of a Special Issue entitled SI:Autophagy.

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  • Pathological proteins associated with familial Alzheimer's disease are either autophagy substrates, such as amyloid-β and tau, or linked to autophagy regulation, such as presenilin and clusterin.

    “Moreover, pathological proteins associated with familial Alzheimer’s disease are either autophagy substrates, such as amyloid-β and tau, or linked to autophagy regulation, such as presenilin and clusterin [148].”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [148]

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Metadata

Authors
Yoon, S.-Y., & Kim, D.-H.
Venue
Brain Research
Publisher
Elsevier BV
Published
2016-10
Volume
1649
Pages
201-209
ISSN
0006-8993
DOI
10.1016/j.brainres.2016.03.018
Cited by
42
References
31
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Ministry of Science, ICT and Future Planning (2008-0062286)

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