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Cited by 343Polymer Surface Interaction StudiesNitric Oxide and Endothelin EffectsHydrogels: synthesis, properties, applications

The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.

Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices

Frost, Megan C., Reynolds, Melissa M., Meyerhoff, Mark E.·2005·Biomaterials
DOI 10.1016/j.biomaterials.2004.06.006
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Abstract

The current state-of-the-art with respect to the preparation, characterization and biomedical applications of novel nitric oxide (NO) releasing or generating polymeric materials is reviewed. Such materials show exceptional promise as coatings to prepare a new generation of medical devices with superior biocompatiblity. Nitric oxide is a well-known inhibitor of platelet adhesion and activation, as well as a potent inhibitor of smooth muscle cell proliferation. Hence, polymers that release or generate NO locally at their surface exhibit greatly enhanced thromboresistivity and have the potential to reduce neointimal hyperplasia caused by device damage to blood vessel walls. In this review, the use of diazeniumdiolates and nitrosothiols as NO donors within a variety polymeric matrixes are summarized. Such species can either be doped as discrete NO donors within polymeric films, or covalently linked to polymer backbones and/or inorganic polymeric filler particles that are often employed to enhance the strength of biomedical polymers (e.g., fumed silica or titanium dioxide). In addition, very recent efforts to create catalytic polymers possessing immobilized Cu(II) sites capable of generating NO from endogenous oxidized forms of NO already present in blood and other physiological fluids (nitrite and nitrosothiols) are discussed. Preliminary literature data illustrating the efficacy of the various NO release/generating polymers as coatings for intravascular sensors, extracorporeal blood loop circuits, and arteriovenous grafts/shunts are reviewed.

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Research works printed but not linked: 6

  1. Roy-Chaudhury, 2002, Vascular brachytherapy for hemodialysis vascular access dysfunction, J Invas Cardiol, 14, 25E
  2. Feng, 2000, Reconstitution of thrombomodulin into polymerizable phospholipid vesicles, Polym Prepr, 41, 16
  3. Makrides SC, Ryan US. Overview of the endothelium. In: Loscalzo J, Schafer AI, editors. Thrombosis and hemorrhage, 2nd ed. Baltimore: Williams & Wilkins; 1998. p. 295–306 [Chapter 13].
  4. Annich, 2000, Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers, Crit Care Med, 28, 915, 10.1097/00003246-200004000-00001 · DOI
  5. Batchelor MM. Synthesis, characterization of nitric oxide releasing agents/polymer for biomedical applications. Ph.D. dissertation, University of Michigan, 2004. p. 157–230.
  6. Bohl, 2000, Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation, Biomaterials, 21, 2273, 10.1016/S0142-9612(00)00153-8 · DOI

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Metadata

Authors
Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E.
Affiliations
University of Michigan (US)
Corresponding author
Meyerhoff, Mark E.
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2005-05
Volume
26
Issue
14
Pages
1685-1693
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2004.06.006
OpenAlex
W2037640551
Cited by
343
References
69
Citations by year
2026: 11 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 25 · 2015: 18 · 2014: 24 · 2013: 24 · 2012: 21
FWCI
0.79
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords
nitric oxide donors, blood-contacting devices, biocompatibility, thromboresistance, intimal hyperplasia, diazeniumdiolates, S-nitrosothiols, polymer coatings, covalent polymerization, fumed silica, titanium dioxide, nitrite, extracorporeal circuit, arteriovenous graft
MeSH terms
Animals, Biocompatible Materials, Blood, Delayed-Action Preparations, Equipment and Supplies, Humans, Nitric Oxide, Platelet Adhesiveness, Polymers, Thrombosis

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