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Cited by 65Polymer Surface Interaction StudiesAnalytical Chemistry and SensorsNitric Oxide and Endothelin Effects

Nitric oxide-releasing/generating polymers for the development of implantable chemical sensors with enhanced biocompatibility

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Wu, Yiduo, Meyerhoff, Mark E.·2008·Talanta
DOI 10.1016/j.talanta.2007.06.022PMC PMC2442581
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Abstract

The development of reliable in vivo chemical sensors for real-time clinical monitoring of blood gases, electrolytes, glucose, etc. in critically ill and diabetic patients remains a great challenge owing to inherent biocompatibility problems that can cause errant analytical results upon sensor implantation (e.g., cell adhesion, thrombosis, inflammation). Nitric oxide (NO) is a well-known inhibitor of platelet activation and adhesion, and also a potent inhibitor of smooth muscle cell proliferation. In addition, NO mediates inflammatory response and promotes angiogenesis. Polymers that release or generate NO at their surfaces have been shown to exhibit greatly enhanced thromboresistance in vivo when in contact with flowing blood, as well as reduce inflammatory response when placed subcutaneously, and thus have the potential to improve the biocompatibility of implanted chemical sensors. Locally elevated NO levels at the surface of implanted devices can be achieved by using polymers that incorporate NO donor species that can decompose and release NO spontaneously when in contact with physiological fluids, or NO-generating polymers that possess an immobilized catalyst that decompose endogenous S-nitrosothiols to generate NO in situ. The potential use of such NO-releasing/generating materials for preparing in vivo sensors implanted either intravascularly or subcutaneously, is examined in this review.

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  • Platelet adhesion and thrombus on sensor surfaces can isolate the sensing area, cause false analytical results, and increase emboli or stroke risk.

    “However, adhesion of platelets, and eventual thrombus formation on the surface of the sensors can occur within a few hours after blood contact, and such processes can not only isolate the chemical sensing area from the bulk of the blood and lead to false analytical results but also increase the risk of emboli or stroke.8,265”

    From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [8]

  • Platelet adhesion and thrombus formation on intravascular sensor surfaces can occur within hours after blood contact.

    “However, adhesion of platelets, and eventual thrombus formation on the surface of the sensors can occur within a few hours after blood contact, and such processes can not only isolate the chemical sensing area from the bulk of the blood and lead to false analytical results but also increase the risk of emboli or stroke.8,265”

    From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [8]

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Authors
Wu, Y., & Meyerhoff, M. E.
Affiliations
University of Michigan (US)
Corresponding author
Meyerhoff, Mark E.
ORCID
Venue
Talanta
Publisher
Elsevier BV
Published
2008-05-15
Volume
75
Issue
3
Pages
642-650
ISSN
0039-9140 (ISSN-L)
DOI
10.1016/j.talanta.2007.06.022
PMC
PMC2442581
OpenAlex
W2064709994
Cited by
65
References
76
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 6
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Talanta (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Biomedical Imaging and Bioengineering (R01EB000783)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
nitric oxide, biocompatibility, thromboresistance, anti-inflammatory response, antiplatelet activity, blood gas monitoring, glucose monitoring, electrolyte monitoring
MeSH terms
Biocompatible Materials, Humans, Monitoring, Physiologic, Nitric Oxide, Polymers, Biosensing Techniques, Infusion Pumps, Implantable

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