Nitric Oxide-Releasing Hydrophobic Polymers: Preparation, Characterization, and Potential Biomedical Applications
Abstract
The synthetic methods used recently in this laboratory to prepare a variety of novel nitric oxide (NO)-releasing hydrophobic polymers are reviewed. Nitric oxide is a well known inhibitor of platelet adhesion and activation. Thus, such NO release polymers have potential applications as thromboresistant coatings for a large number of blood-contacting biomedical devices (e.g., in vivo sensors, arteriovenous grafts, stents, catheters, extracorporeal circuits). The approaches taken to prepare NO releasing poly(vinyl chloride) (PVC), silicone rubber (SR), polymethacrylate (PM), and polyurethane (PU) materials are grouped into three categories: (1) dispersion/doping of discrete diazeniumdiolated molecules within the polymeric films; (2) chemical derivatization of polymeric filler microparticles (e.g., silicon dioxide, titanium dioxide) to possess NO release chemistry and then their dispersion within the hydrophobic polymers; and (3) covalent attachment of NO release moieties to polymer backbones. Specific chemical examples of each of these approaches are summarized and the advantages and disadvantages of each are discussed. Other related work in the field of NO release polymers is also cited. It is further shown that several of the NO-releasing polymeric materials already prepared exhibit the expected improved thromboresistivity when tested in vivo using appropriate animal models.
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Three main strategies for increasing NO bioavailability are exercise/diet, drugs that alter enzymatic NO production, and modified polymeric materials that deliver NO exogenously.
“There are three main strategies for increasing NO bioavailability: 1) by participating in physical exercise and controlling certain dietary components (e.g., nitrate-rich diet);132,133 2) by administrating drugs that alter the enzymatic production of NO through nitric oxide synthases (NOSs) and increase the biosynthesis of NO endogenously;117 and 3) by using modified polymeric materials that can”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [110]
Meyerhoff and coworkers were among the first to link NO donors to particle fillers or to polymer backbones such as PVC, polyurethane, and silicone rubber.
“Meyerhoff and coworkers were among the first to link these NO donors to particle fillers (such as fumed silica particles236) or to the polymer backbone of polymers such as PVC,34,237 polyurethane (PU),34,110,233 and silicone rubber (SR).238”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [110]
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Self-citationCarbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants
Nair, H. A. S., Subramoni, S., Poh, W. H., Hasnuddin, N. T. B., Tay, M., Givskov, M., Tolker‐Nielsen, T., Kjelleberg, S. J., McDougald, D., & Rice, S. A. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02318-8 · Cited by 18 · see citing works
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Self-citationAccurate Nitric Oxide Measurements from Donors in Cell Media: Identification of Scavenging Agents
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Mechanistic analysis of the photolytic decomposition of solid-state S-nitroso-N-acetylpenicillamine
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Polycarbonateurethane films containing complex of copper(II) catalyzed generation of nitric oxide
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Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release
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Self-citation
- Authors
- Reynolds, M. M., Frost, M. C., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Meyerhoff, Mark E.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 37
- Issue
- 7
- Pages
- 926-936
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2059930779
- Cited by
- 116
- References
- 45
- Citations by year
- 2026: 5 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 2
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- hydrophobic polymers, thromboresistance, platelet adhesion inhibition, polyvinyl chloride, silicone rubber, polymethacrylates, polyurethane, diazeniumdiolates, polymer doping, arteriovenous graft, stents, catheters, extracorporeal circuit
- MeSH terms
- Animals, Blood Vessels, Humans, Nitric Oxide, Polymers, Nitric Oxide Donors, Hydrophobic and Hydrophilic Interactions
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