Cited by 343Polymer Surface Interaction StudiesNitric Oxide and Endothelin EffectsHydrogels: synthesis, properties, applications

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Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices

Frost, Megan C., Reynolds, Melissa M., Meyerhoff, Mark E.·2005·Biomaterials

DOI 10.1016/j.biomaterials.2004.06.006

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Abstract

The current state-of-the-art with respect to the preparation, characterization and biomedical applications of novel nitric oxide (NO) releasing or generating polymeric materials is reviewed. Such materials show exceptional promise as coatings to prepare a new generation of medical devices with superior biocompatiblity. Nitric oxide is a well-known inhibitor of platelet adhesion and activation, as well as a potent inhibitor of smooth muscle cell proliferation. Hence, polymers that release or generate NO locally at their surface exhibit greatly enhanced thromboresistivity and have the potential to reduce neointimal hyperplasia caused by device damage to blood vessel walls. In this review, the use of diazeniumdiolates and nitrosothiols as NO donors within a variety polymeric matrixes are summarized. Such species can either be doped as discrete NO donors within polymeric films, or covalently linked to polymer backbones and/or inorganic polymeric filler particles that are often employed to enhance the strength of biomedical polymers (e.g., fumed silica or titanium dioxide). In addition, very recent efforts to create catalytic polymers possessing immobilized Cu(II) sites capable of generating NO from endogenous oxidized forms of NO already present in blood and other physiological fluids (nitrite and nitrosothiols) are discussed. Preliminary literature data illustrating the efficacy of the various NO release/generating polymers as coatings for intravascular sensors, extracorporeal blood loop circuits, and arteriovenous grafts/shunts are reviewed.

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Self-citation

Authors: Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E.
Affiliations: University of Michigan (US)
Corresponding author: Meyerhoff, Mark E.
ORCID: Frost, Megan C.
Reynolds, Melissa M.
Meyerhoff, Mark E.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2005-05
Volume: 26
Issue: 14
Pages: 1685-1693
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2004.06.006
OpenAlex: W2037640551
Cited by: 343
References: 69
Citations by year: 2026: 11 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 22 · 2018: 20 · 2017: 16 · 2016: 25 · 2015: 18 · 2014: 24 · 2013: 24 · 2012: 21
FWCI: 0.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: nitric oxide donors, blood-contacting devices, biocompatibility, thromboresistance, intimal hyperplasia, diazeniumdiolates, S-nitrosothiols, polymer coatings, covalent polymerization, fumed silica, titanium dioxide, nitrite, extracorporeal circuit, arteriovenous graft
MeSH terms: Animals, Biocompatible Materials, Blood, Delayed-Action Preparations, Equipment and Supplies, Humans, Nitric Oxide, Platelet Adhesiveness, Polymers, Thrombosis

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Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices

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