The effect of gelatin incorporation into electrospun poly(l-lactide-co-ɛ-caprolactone) fibers on mechanical properties and cytocompatibility
Abstract
Very elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL) (50:50) copolymer blended with gelatin was electrospun into microfibers from a hexafluoroisopropanol solution. PLCL fiber sheet exhibited the unique soft and flexible behavior while gelatin fiber was hard and brittle. As the gelatin content of PLCL/gelatin fibers increased, Young's modulus was increased, but the elongation was decreased compared to those of PLCL. However, fibers containing 10-30 wt% gelatin demonstrated an enhanced tensile strength with still high elongation to be beneficial for tissue engineering scaffolds. The cytocompatibility of electrospun fiber sheets was evaluated by fibroblasts (NIH-3T3) cell culture. The initial cell adhesion on various fibers after 5h was somewhat similar, but in the order of PLCL>PLCL70/gelatin30 approximately PLCL50/gelatin50>PLCL90/gelatin10 approximately gelatin>PLCL30/gelatin70. However, the cell proliferation exhibited a completely different and strong dependence on the fiber composition: a very high proliferation rate on PLCL90/gelatin10, followed by PLCL>gelatin>PLCL70/gelatin30. Such an enhanced effect of gelatin, especially at 10 wt% content, on strength and cytocompatibility of PLCL/gelatin fibers would be very preferable for tissue engineering scaffolds.
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High molecular weight PLCL generally exhibits a higher elastic modulus, maintains better shape stability under loading, and is suitable for applications subjected to heavy loads.
“High molecular weight PLCL generally exhibits a higher elastic modulus, which allows it to maintain better shape stability under loading, and is suitable for applications subjected to heavy loads [56].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [56]
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- Authors
- Lee, J., Tae, G., Kim, Y. H., Park, I. S., Kim, S.-H., & Kim, S. H.
- Affiliations
- Gwangju Institute of Science and Technology (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Kim, Young Ha
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 29
- Issue
- 12
- Pages
- 1872-1879
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1963578821
- Cited by
- 200
- References
- 31
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 1 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 21 · 2015: 8 · 2014: 11 · 2013: 17 · 2012: 15
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- poly(L-lactide-co-ε-caprolactone), gelatin, electrospun nanofibers, copolymer blends, mechanical properties, Young's modulus, tensile strength, cell adhesion, cell proliferation, cytocompatibility, tissue engineering scaffolds
- MeSH terms
- Animals, Biocompatible Materials, Cell Survival, Elasticity, Electrochemistry, Gelatin, Materials Testing, Polyesters, Rotation, Stress, Mechanical, Tensile Strength, Porosity, NIH 3T3 Cells, Mice
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