How do polymeric micelles cross epithelial barriers?
Abstract
Non-parenteral delivery of drugs using nanotechnology-based delivery systems is a promising non-invasive way to achieve effective local or systemic drug delivery. The efficacy of drugs administered non-parenterally is limited by their ability to cross biological barriers, and epithelial tissues particularly present challenges. Polymeric micelles can achieve transepithelial drug delivery because of their ability to be internalized into cells and/or cross epithelial barriers, thereby delivering drugs either locally or systematically following non-parenteral administration. This review discusses the particular characteristics of various epithelial barriers and assesses their potential as non-parenteral routes of delivery. The material characteristics of polymeric micelles (e.g., size, surface charge, and surface decoration) and of unimers dissociated from polymeric micelles determine their interactions (non-specific and/or specific) with mucus and epithelial cells as well as their intracellular fate. This paper outlines the mechanisms governing the major modes of internalization of polymeric micelles into epithelial cells, with an emphasis on specific recent examples of the transport of drug-loaded polymeric micelles across epithelial barriers.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Amphiphilic polymers used for micelles preparation can interact with biological membranes and display inherent biological activity, including an inhibitory effect on efflux pumps responsible for MDR in chemotherapy.
“Additionally, amphiphilic polymers used for micelles preparation can interact with biological membranes and display inherent biological activity: it is well known the inhibitory effect of several polymers on the efflux pumps responsible for MDR in chemotherapy [22,23].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
The CMC value is the most important parameter to define micelles thermodynamic stability.
“The CMC value is the most important parameter to define micelles thermodynamic stability.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
Kinetic stability is an index of the micelles tendency to disassembly over time when the system is diluted below the CMC.
“In addition to thermodynamic stability, another fundamental parameter is the kinetic stability, an index of the micelles tendency to disassembly over time when the system is diluted below the CMC [22].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
The length of the polymer hydrophobic chain, in addition to the type and level of substituents, is pivotal for defining the degree of encapsulation.
“The length of the polymers hydrophobic chain, in addition to the type and level of substituents, is pivotal for defining the degree of encapsulation [22,81].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
Differences in micellar shape are mainly related to the structure of polymers used and to the characteristics of the surrounding environment in terms of temperature, pH and composition.
“The differences in micellar shape are mainly related to the structure of polymers used [22,74] and to the characteristics of the surrounding environment in terms of temperature, pH and composition [74].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
Although micelles are commonly depicted as spherical systems, rod-like, worm-like or disk-like structures can be observed.
“Although micelles are commonly depicted as spherical systems, in some cases it is possible to observe the presence of rod-like, worm-like or even disk-like structures [22,72,73].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
For hydrophobic drugs, the amount loaded strictly depends on the hydrophobic interactions occurring between the drug and the micellar core.
“Concerning hydrophobic drugs, the amount loaded strictly depends on the hydrophobic interactions occurring between the drug and the micellar core.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
Size and surface charge are involved in the regulation of the biodistribution and pharmacokinetic properties of micellar systems, so their determination by DLS is fundamental to predict micelles behavior when in contact with body fluids and tissues.
“As size and surface charge are involved in the regulation of the biodistribution and pharmacokinetic properties of micellar systems, their determination by DLS is fundamental to predict micelles behavior when in contact with body fluids and tissues [22,64].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [22]
Cites
Membrane lipids: where they are and how they behave
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157 · see citing works
Lewinski, N. A., Colvin, V. L., & Drezek, R. A. (2007) · Small · doi:10.1002/smll.200700595 · Cited by 2,812 · see citing works
Shape effects of filaments versus spherical particles in flow and drug delivery
Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.70 · Cited by 2,565 · see citing works
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181 · see citing works
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,827 · see citing works
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,824 · see citing works
Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
Ensign, L. M., Cone, R. A., & Hanes, J. S. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.009 · Cited by 1,630 · see citing works
Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459 · see citing works
Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406 · see citing works
Inhaling medicines: delivering drugs to the body through the lungs
Patton, J. S., & Byron, P. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2153 · Cited by 1,329 · see citing works
Micro- and macrorheology of mucus
Lai, S. K., Wang, Y.-Y., Wirtz, D., & Hanes, J. S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.012 · Cited by 1,228 · see citing works
Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles
Savić, R., Luo, L., Eisenberg, A., & Maysinger, D. (2003) · Science · doi:10.1126/science.1078192 · Cited by 1,113 · see citing works
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050 · see citing works
Balancing forces: architectural control of mechanotransduction
DuFort, C. C., Paszek, M. J., & Weaver, V. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3112 · Cited by 987 · see citing works
Owen, S. C., Chan, D. P. Y., & Shoichet, M. S. (2012) · Nano Today · doi:10.1016/j.nantod.2012.01.002 · Cited by 911 · see citing works
Functional aspects of the tear film lipid layer
Bron, A. J., Tiffany, J. M., Gouveia, S. M., Yokoi, N., & Voon, L. W. (2003) · Experimental Eye Research · doi:10.1016/j.exer.2003.09.019 · Cited by 784 · see citing works
Shuai, X., Ai, H., Nasongkla, N., Kim, S., & Gao, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.003 · Cited by 695 · see citing works
Inhaled nanoparticles—A current review
Yang, W. P., Peters, J. I., & Williams, R. O. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.02.011 · Cited by 670 · see citing works
Lukyanov, A. N., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.004 · Cited by 654 · see citing works
Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs
Lu, Y., & Park, K. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.042 · Cited by 572 · see citing works
Nanotechnology in ocular drug delivery
Sahoo, S. K., Dilnawaz, F., & Krishnakumar, S. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.10.021 · Cited by 554 · see citing works
Challenges for the oral delivery of macromolecules
Goldberg, M. F., & Gómez-Orellana, I. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1067 · Cited by 545 · see citing works
Diffusion of Macromolecules and Virus-Like Particles in Human Cervical Mucus
Olmsted, S. S., Padgett, J. L., Yudin, A. I., Whaley, K. J., Moench, T. R., & Cone, R. A. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75844-4 · Cited by 544 · see citing works
Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA–PEG block copolymer
Yoo, H. S., & Park, T. G. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00340-0 · Cited by 539 · see citing works
Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances
Xu, S., Olenyuk, B. Z., Okamoto, C. T., & Hamm‐Alvarez, S. F. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.041 · Cited by 469 · see citing works
Distribution of mucins at the ocular surface
Gipson, I. K. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00204-5 · Cited by 441 · see citing works
Chen, H., Kim, S., Li, L., Wang, S., Park, K., & Cheng, J.-X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707046105 · Cited by 394 · see citing works
Polymeric micelles for oral drug delivery
Gaucher, G., Satturwar, P., Jones, M.-C., Furtos, A., & Leroux, J.-C. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.06.007 · Cited by 389 · see citing works
Biological hydrogels as selective diffusion barriers
Lieleg, O., & Ribbeck, K. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.002 · Cited by 387 · see citing works
Deli, M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.016 · Cited by 385 · see citing works
Nanotechnology in Ocular Drug Delivery
Patel, D. H., Pathak, D., & Giradkar, P. (2021) · Springer eBooks · doi:10.1007/978-981-33-4497-6_18 · Cited by 362 · see citing works
Chitosan-based drug nanocarriers: Where do we stand?
García-Fuentes, M., & Alonso, M. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.017 · Cited by 354 · see citing works
Chitosan-based nanostructures: A delivery platform for ocular therapeutics
de la Fuente, M., Raviña, M., Paolicelli, P., Sánchez, A., Seijo, B., & Alonso, M. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.026 · Cited by 354 · see citing works
Fate of polymeric nanocarriers for oral drug delivery
Plapied, L., Duhem, N., Rieux, A. D., & Véronique Préat, A. (2011) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.12.005 · Cited by 320 · see citing works
Challenges in design and characterization of ligand-targeted drug delivery systems
Muro, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.052 · Cited by 308 · see citing works
Uptake mechanisms of non-viral gene delivery
Xiang, S., Tong, H., Shi, Q., Fernandes, J., Jin, T., Dai, K., & Zhang, X. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.093 · Cited by 284 · see citing works
Nanoparticles for nasal vaccination
Csaba, N., García-Fuentes, M., & Alonso, M. J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.005 · Cited by 277 · see citing works
Vasir, J. K., & Labhasetwar, V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.020 · Cited by 268 · see citing works
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera.
Hämäläinen, K. M., Kananen, K., Auriola, S. O. K., Kontturi, K., & Urtti, A. O. (1997) · PubMed · Cited by 266 · see citing works
Liu, S. Q., Tong, Y. W., & Yang, Y.-Y. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.01.030 · Cited by 265 · see citing works
Controlled pulmonary drug and gene delivery using polymeric nano-carriers
Beck-Broichsitter, M., Merkel, O. M., & Kissel, T. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.004 · Cited by 200 · see citing works
The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles
Mo, R., Jin, X., Li, N., Ju, C., Sun, M., Zhang, C., & Ping, Q. N. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.005 · Cited by 199 · see citing works
Cellular Internalization of Poly(ethylene oxide)-b-poly(ε-caprolactone) Diblock Copolymer Micelles
Luo, L., Tam, J., Maysinger, D., & Eisenberg, A. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025524y · Cited by 199 · see citing works
Gan, L., Han, S., Shen, J., Zhu, J., Zhu, C., Zhang, X., & Gan, Y. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.06.015 · Cited by 197 · see citing works
Sahay, G., Batrakova, E. V., & Kabanov, A. V. (2008) · Bioconjugate Chemistry · doi:10.1021/bc8002315 · Cited by 184 · see citing works
Collnot, E.-M., Baldes, C., Wempe, M. F., Hyatt, J. A., Navarro, L., Edgar, K. J., Schaefer, U. F., & Lehr, C. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.005 · Cited by 184 · see citing works
Gill, K. K., Nazzal, S., & Kaddoumi, A. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.04.017 · Cited by 173 · see citing works
Widera, A., Norouziyan, F., & Shen, W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.07.004 · Cited by 173 · see citing works
Sahay, G., Kim, J. O., Kabanov, A. V., & Bronich, T. K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.101 · Cited by 171 · see citing works
Model of transient drug diffusion across cornea
Zhang, W., Prausnitz, M. R., & Edwards, A. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.001 · Cited by 166 · see citing works
Mao, S., Germershaus, O., Fischer, D., Linn, T., Schnepf, R., & Kissel, T. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8175-y · Cited by 164 · see citing works
Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells
Vogel, U. B., Sandvig, K., & van Deurs, B. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.6.825 · Cited by 162 · see citing works
Gupta, A. K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00508-1 · Cited by 160 · see citing works
Effect of Pluronic P85 on ATPase Activity of Drug Efflux Transporters
Batrakova, E. V., Li, S., Li, Y., Alakhov, V. Y., & Kabanov, A. V. (2004) · Pharmaceutical Research · doi:10.1007/s11095-004-7675-5 · Cited by 158 · see citing works
Recent advances in nanocarrier-based mucosal delivery of biomolecules
Kammona, O., & Kiparissides, C. A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.040 · Cited by 142 · see citing works
Vercauteren, D., Rejman, J., Martens, T., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.020 · Cited by 134 · see citing works
Di Tommaso, C., Bourges, J.-L., Valamanesh, F., Trubitsyn, G., Torriglia, A., Jeanny, J.-C., Behar-Cohen, F., Gurny, R., & Möller, M. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.02.014 · Cited by 128 · see citing works
Rapoport, N. Y., Marin, A., Luo, Y., Prestwich, G. D., & Muniruzzaman, M. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10006 · Cited by 128 · see citing works
Liaw, J., Chang, S.-F., & Hsiao, F.-C. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301485 · Cited by 125 · see citing works
Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.06.002 · Cited by 123 · see citing works
Polyhydroxyethylaspartamide-based micelles for ocular drug delivery
Civiale, C., Licciardi, M., Cavallaro, G., Giammona, G., & Mazzone, M. G. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.05.028 · Cited by 120 · see citing works
Dahmani, F. Z., Yang, H., Zhou, J., Yao, J., Zhang, T., & Zhang, Q. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.05.015 · Cited by 119 · see citing works
Cellular internalization of PCL20-b-PEO44 block copolymer micelles
Allen, C. J., Yu, Y., Eisenberg, A., & Maysinger, D. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00108-x · Cited by 112 · see citing works
Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery
Xiong, X.-B., Binkhathlan, Z., Molavi, O., & Lavasanifar, A. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.03.006 · Cited by 111 · see citing works
Challenges facing colloidal delivery systems: From synthesis to the clinic
Johnston, A. P. R., Such, G. K., Ng, S. L., & Caruso, F. (2010) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.11.003 · Cited by 107 · see citing works
Stabilized micelles as delivery vehicles for paclitaxel
Yoncheva, K., Calleja, P., Agüeros, M., Petrov, P. D., Miladinova, I., Tsvetanov, C. B., & Irache, J. M. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.030 · Cited by 102 · see citing works
The potential of chitosan for the oral administration of peptides
Prego, C., Torres, D., & Alonso, M. J. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.5.843 · Cited by 102 · see citing works
Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
Mathot, F., van Beijsterveldt, L., Véronique Préat, A., Brewster, M. E., & Ariën, A. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.012 · Cited by 101 · see citing works
Ould-Ouali, L., Noppe, M., Langlois, X., Willems, B., Riele, P. T., Timmerman, P., Brewster, M. E., Ariën, A., & Véronique Préat, A. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.022 · Cited by 95 · see citing works
A Nonionic Surfactant/Chitosan Micelle System in an Innovative Eye Drop Formulation
Pepić, I., Hafner, A., Lovrić, J., Pirkić, B., & Filipović‐Grčić, J. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22137 · Cited by 94 · see citing works
Lin, H., Gebhardt, M., Bian, S., Kwon, K. A., Shim, C., Chung, S.-J., & Kim, D. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.043 · Cited by 92 · see citing works
Vercauteren, D., Piest, M., van der Aa, L. J., Al-Soraj, M. H., Jones, A. T., Engbersen, J. F. J., Smedt, S. C. D., & Braeckmans, K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.045 · Cited by 92 · see citing works
Ocular Drug Delivery; Impact of in vitro Cell Culture Models.
Barar, J., Asadi, M., Mortazavi‐Tabatabaei, S. A., & Omidi, Y. (2009) · PubMed Central · Cited by 90 · see citing works
Exploiting the Vitamin B12 Pathway To Enhance Oral Drug Delivery via Polymeric Micelles
Francis, M. F., Cristea, M., & Winnik, F. M. (2005) · Biomacromolecules · doi:10.1021/bm0503165 · Cited by 84 · see citing works
Di Tommaso, C., Torriglia, A., Furrer, P., Behar-Cohen, F., Gurny, R., & Möller, M. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.01.004 · Cited by 84 · see citing works
Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier
Mathot, F., Rieux, A. D., Ariën, A., Schneider, Y., Brewster, M. E., & Véronique Préat, A. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.001 · Cited by 84 · see citing works
Shahin, M., Ahmed, S., Kaur, K., & Lavasanifar, A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.061 · Cited by 82 · see citing works
Zhao, S., Dai, W., He, B., Wang, J., He, Z., Zhang, X., & Zhang, Q. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.018 · Cited by 82 · see citing works
Satturwar, P. M., Nasser‐Eddine, M., Ravenelle, F., & Leroux, J. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.09.012 · Cited by 77 · see citing works
Ostacolo, C., Caruso, C., Tronino, D., Troisi, S., Laneri, S., Pacente, L., Prete, A., & Sacchi, A. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.09.051 · Cited by 72 · see citing works
Eye drop delivery of nano‐polymeric micelle formulated genes with cornea‐specific promoters
Tong, Y.-C., Chang, S., Liu, C., Kao, W. W. ‐., Huang, C. H., & Liaw, J. (2007) · The Journal of Gene Medicine · doi:10.1002/jgm.1093 · Cited by 71 · see citing works
Bayındır, Z. S., Yüksel, N., & Baykara, T. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.09.030 · Cited by 67 · see citing works
Absorption-promoting effects of chitosan in airway and intestinal cell lines: A comparative study
Vllasaliu, D., Casettari, L., Fowler, R., Exposito-Harris, R., Garnett, M. C., Illum, L., & Stolnik, S. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.04.012 · Cited by 67 · see citing works
Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS
Wempe, M. F., Wright, C., Little, J. L., Lightner, J., Large, S. E., Caflisch, G. B., Buchanan, C. M., Rice, P. J., Wacher, V. J., & Ruble, K. M. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.11.021 · Cited by 64 · see citing works
Ghaffarian, R., Bhowmick, T. K., & Muro, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.007 · Cited by 63 · see citing works
Ocular Drug Delivery: Impact of In Vitro Cell Culture Models
Solanki, A., Desai, S., Grover, A., Hirani, A., Pathak, Y. V., & Sutariya, V. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-29346-2_21 · Cited by 61 · see citing works
Amphiphilic peptide carrier for the combined delivery of curcumin and plasmid DNA into the lungs
Park, J. H., Kim, H. A., Park, J. H., & Lee, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.046 · Cited by 59 · see citing works
Li, N., Li, X., Zhou, Y., Li, W., Zhao, Y. S., Ma, S., Li, J., Gao, Y., Liu, Y., Wang, X., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.047 · Cited by 57 · see citing works
Thiol-Functionalized Polymeric Micelles: From Molecular Recognition to Improved Mucoadhesion
Dufresne, M.-H., Gauthier, M. A., & Leroux, J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050007b · Cited by 56 · see citing works
The utilization of pathogen-like cellular trafficking by single chain block copolymer
Sahay, G., Gautam, V., Luxenhofer, R., & Kabanov, A. V. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.020 · Cited by 51 · see citing works
Tocol modified glycol chitosan for the oral delivery of poorly soluble drugs
Duhem, N., Rolland, J., Riva, R., Guillet, P., Schumers, J., Jérôme, C., Gohy, J., & Véronique Préat, A. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.12.010 · Cited by 50 · see citing works
Phospholipid–polyaspartamide micelles for pulmonary delivery of corticosteroids
Craparo, E. F., Teresi, G., Bondı̀, M. L., Licciardi, M., & Cavallaro, G. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.024 · Cited by 46 · see citing works
Interactions in a nonionic surfactant and chitosan mixtures
Pepić, I., Filipović‐Grčić, J., & Jalšenjak, I. (2008) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2008.06.009 · Cited by 45 · see citing works
Bulk properties of nonionic surfactant and chitosan mixtures
Pepić, I., Filipović‐Grčić, J., & Jalšenjak, I. (2008) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2008.11.034 · Cited by 40 · see citing works
González‐Mariscal, L., & Nava, P. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.004 · Cited by 38 · see citing works
Enhancing effect of N-octyl-O-sulfate chitosan on etoposide absorption
Mo, R., Xiao, Y., Sun, M., Zhang, C., & Ping, Q. N. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.021 · Cited by 37 · see citing works
Kondoh, M., Takahashi, A., & Yagi, K. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.07.004 · Cited by 37 · see citing works
Tong, Y.-C., Chang, S., Kao, W. W. ‐., Liu, C., & Liaw, J. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.006 · Cited by 36 · see citing works
Permeation of PEO-PBLA-FITC Polymeric Micelles in Aortic Endothelial Cells
Liaw, J., Aoyagi, T., Kataoka, K., Sakurai, Y., & Okano, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1012157906528 · Cited by 32 · see citing works
Lafitte, G., Thuresson, K., Jarwoll, P., & Nydén, M. (2007) · Langmuir · doi:10.1021/la701081s · Cited by 30 · see citing works
Kabanov, A. V., Slepnev, V. I., Kuznetsova, L. E., Batrakova, E. V., VYu, A., Melik‐Nubarov, N. S., Sveshnikov, P. G., & Kabanov, V. A. (1992) · PubMed · Cited by 25 · see citing works
Lafitte, G., Thuresson, K., & Söderman, O. (2005) · Langmuir · doi:10.1021/la0472807 · Cited by 23 · see citing works
Lim, C.-J., Norouziyan, F., & Shen, W. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.021 · Cited by 20 · see citing works
Ethanol enhanced in vivo gene delivery with non-ionic polymeric micelles inhalation
Chao, Y.-C., Chang, S., Lu, S., Hwang, T., Hsieh, W.-H., & Liaw, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.007 · Cited by 17 · see citing works
Berginc, K., Trontelj, J., & Kristl, A. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.03.015 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Nanotherapeutics in the EU: an overview on current state and future directions
Pepić, I., Hafner, A., Lovrić, J., & Lakoš, G. P. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s55359 · Cited by 295 · see citing works
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154 · see citing works
Polymeric micelles in mucosal drug delivery: challenges towards clinical translation
Sosnik, A., & Menaker Raskin, M. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.003 · Cited by 154 · see citing works
Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases
Deng, Z., Kalin, G. T., Shi, D., & Kalinichenko, V. V. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0306tr · Cited by 129 · see citing works
Polymeric micelles as mighty nanocarriers for cancer gene therapy: a review
Yousefpour Marzbali, M., & Yari Khosroushahi, A. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3273-1 · Cited by 115 · see citing works
Polymeric micelles for oral drug administration enabling locoregional and systemic treatments
Simões, S. M. N., Figueiras, A., Veiga, F., Concheiro, Á., & Alvarez‐Lorenzo, C. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.960841 · Cited by 116 · see citing works
Formulation of Nanomicelles to Improve the Solubility and the Oral Absorption of Silymarin
Piazzini, V., D’Ambrosio, M., Luceri, C., Cinci, L., Landucci, E., Bilia, A. R., & Bergonzi, M. C. (2019) · Molecules · doi:10.3390/molecules24091688 · Cited by 106 · see citing works
Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy
Swetledge, S., Jung, J. P., Carter, R. T., & Sabliov, C. M. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00745-9 · Cited by 97 · see citing works
Duan, Y., Zhang, B., Chu, L., Tong, H. H. Y., Liu, W., & Zhai, G. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.01.017 · Cited by 88 · see citing works
The biological fate of orally administered mPEG-PDLLA polymeric micelles
He, H., Wang, L., Ma, Y., Yang, Y., Lv, Y., Zhang, Z., Qi, J., Dong, X., Zhao, W., Lü, Y., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.024 · Cited by 82 · see citing works
Mehra, N., Aqil, M., & Sultana, Y. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105735 · Cited by 79 · see citing works
Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system
Horvát, G., Gyarmati, B., Berkó, S., Szabó‐Révész, P., Szilágyi, B. Á., Szilágyi, A., Soós, J., Sandri, G., Bonferoni, M. C., Rossi, S., et al. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.10.013 · Cited by 79 · see citing works
Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1597848 · Cited by 78 · see citing works
Acrylated chitosan for mucoadhesive drug delivery systems
Shitrit, Y., & Bianco‐Peled, H. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.023 · Cited by 74 · see citing works
Prodrugs and nanomicelles to overcome ocular barriers for drug penetration
Gote, V., Michael, A., & Pal, D. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1803278 · Cited by 73 · see citing works
Zhao, J., Wang, H., Liu, J., Deng, L., Liu, J., Dong, A., & Zhang, J. (2013) · Biomacromolecules · doi:10.1021/bm401087n · Cited by 68 · see citing works
Micelle-based nanoparticles with stimuli-responsive properties for drug delivery
Maboudi, A. H., Lotfipour, M. H., Rasouli, M., Azhdari, M. H., MacLoughlin, R. J., Bekeschus, S., & Doroudian, M. (2024) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0218 · Cited by 69 · see citing works
Akkuş‐Dağdeviren, Z. B., Nazir, I., Jalil, A., Tribus, M., & Bernkop‐Schnürch, A. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00355 · Cited by 66 · see citing works
Cyclosporine-loaded micelles for ocular delivery: investigating the penetration mechanisms
Ghezzi, M., Ferraboschi, I., Delledonne, A., Pescina, S., Padula, C., Santi, P., Sissa, C., Terenziani, F., & Nicoli, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.019 · Cited by 63 · see citing works
Zeta potential changing nanoemulsions based on a simple zwitterion
Sharifi, F., Jahangiri, M., Nazir, I., Asim, M. H., Ebrahimnejad, P., Hupfauf, A., Gust, R., & Bernkop‐Schnürch, A. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.11.054 · Cited by 60 · see citing works
Piazzini, V., Landucci, E., Urru, M., Chiarugi, A., Pellegrini-Giampietro, D. E., Bilia, A. R., & Bergonzi, M. C. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119361 · Cited by 58 · see citing works
Adamczak, M., Hagesæther, E., Smistad, G., & Hiorth, M. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.030 · Cited by 56 · see citing works
Vasile, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813932-5.00001-7 · Cited by 55 · see citing works
Design of nanostructured lipid carriers and solid lipid nanoparticles for enhanced cellular uptake
Veider, F., Akkuş‐Dağdeviren, Z. B., Knoll, P., & Bernkop‐Schnürch, A. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122014 · Cited by 51 · see citing works
Hafner, A., Lovrić, J., Romić, M. D., Juretić, M., Pepić, I., Cetina‐Čižmek, B., & Filipović‐Grčić, J. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.04.003 · Cited by 48 · see citing works
Bergonzi, M. C., Vasarri, M., Marroncini, G., Barletta, E., & Degl’Innocenti, D. (2020) · Molecules · doi:10.3390/molecules25204707 · Cited by 46 · see citing works
Zhou, T., Zhu, L., Xia, H., He, J., Liu, S., He, S., Wang, L., & Zhang, J. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.08.020 · Cited by 45 · see citing works
Sosnik, A., Shabo, R. B., & Halamish, H. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122142 · Cited by 41 · see citing works
Pescina, S., Grolli Lucca, L., Govoni, P., Padula, C., Del Favero, E., Cantù, L., Santi, P., & Nicoli, S. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090476 · Cited by 38 · see citing works
Li, J., Tan, G., Cheng, B., Liu, D., & Pan, W. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.08.013 · Cited by 38 · see citing works
The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye
Wang, L., Zhou, M., & Zhang, H. (2021) · Ophthalmology and Therapy · doi:10.1007/s40123-021-00365-y · Cited by 40 · see citing works
Farhangi, M. A., Kobarfard, F., Mahboubi, A., Vatanara, A., & Mortazavi, S. A. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1442847 · Cited by 36 · see citing works
Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics
Datta, D., Bandi, S. P., Colaco, V., Dhas, N. L., Reddy, D. S., & Vora, L. K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124192 · Cited by 40 · see citing works
Carbohydrate Based Nanoparticles for Drug Delivery Across Biological Barriers
Peptu, C. A., Ochiuz, L., Alupei, L., Peptu, C., & Popa, M. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1950 · Cited by 34 · see citing works
Liu, D., Li, J., Cheng, B., Wu, Q., & Pan, H. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00069 · Cited by 34 · see citing works
Braga, C. B., Pilli, R. A., Ornelas, C., & Weck, M. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c01196 · Cited by 32 · see citing works
Nazir, I., Leichner, C., Le‐Vinh, B., & Bernkop‐Schnürch, A. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.01.082 · Cited by 31 · see citing works
Recent development of micro-nano carriers for oral antineoplastic drug delivery
Li, H., Chen, X., Rao, S., Zhou, M., Lu, J., Liang, D., Zhu, B., Li, M., Lin, J., Ding, X., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101445 · Cited by 31 · see citing works
Hatton, F. L., Tatham, L. M., Tidbury, L. R., Chambon, P., He, T., Owen, A., & Rannard, S. P. (2014) · Chemical Science · doi:10.1039/c4sc02889a · Cited by 30 · see citing works
Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery
Lü, Z., Bu, C., Hu, W., Zhang, H., Liu, M., Lu, M., & Zhai, G. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1419852 · Cited by 30 · see citing works
Kontogiannis, O., Selianitis, D., Perinelli, D. R., Bonacucina, G., Pippa, Ν., Gazouli, M., & Pispas, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213814 · Cited by 30 · see citing works
The effect of freeze-drying on mucoadhesion and transport of acrylated chitosan nanoparticles
Eliyahu, S., Almeida, A., Macedo, M. H., das Neves, J., Sarmento, B. F. C. C., & Bianco‐Peled, H. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118739 · Cited by 30 · see citing works
Wang, X., Zheng, Y., Qiu, L., Ouyang, H., Xu, X., Xu, W., Zhang, Y., & Xu, W. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122138 · Cited by 29 · see citing works
Application of liposomes in the treatment of infectious diseases
Suhaimi, N. A. A., Ahmad, S., Husna, S. M. N., Sarmiento, M. E., Acosta, A., Norazmi, M. N., Ibrahim, J., Mohamud, R., & Kadir, R. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120734 · Cited by 28 · see citing works
Protamine-mediated efficient transcellular and transmucosal delivery of proteins
Wu, J., Jones, N. B., Fayez, N. A., Chao, P., Wu, A., de Araújo, D. R., Rouhollahi, E., Jia, A., & Li, S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.002 · Cited by 28 · see citing works
Sipos, B., Benei, M., Katona, G., & Csóka, I. (2023) · Molecules · doi:10.3390/molecules28196980 · Cited by 27 · see citing works
The Application of Nanotechnology to Drug Delivery in Medicine
McDonald, T. O., Siccardi, M., Moss, D. M., Liptrott, N. J., Giardiello, M., Rannard, S. P., & Owen, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-62747-6.00007-5 · Cited by 27 · see citing works
Sipos, B., Bella, Z., Gróf, I., Veszelka, S., Deli, M. A., Szűcs, K. F., Sztojkov‐Ivanov, A., Ducza, E., Gáspár, R., Kecskeméti, G., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122594 · Cited by 26 · see citing works
Sipos, B., Katona, G., & Csóka, I. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050702 · Cited by 24 · see citing works
Span, K., Verhoef, J. J. F., Hunt, H., van Nostrum, C. F., Brinks, V., Schellekens, H., & Hennink, W. E. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.09.002 · Cited by 23 · see citing works
Nanomicelles empower natamycin in treating fungal keratitis: An in vitro, ex vivo and in vivo study
Sathe, P., Kailasam, V., Nagarjuna, V., Sharma, H. P., Velpandian, T., Garg, P., & Nirmal, J. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124118 · Cited by 22 · see citing works
Zhang, J., Chen, K., Ding, Y., Xin, X. L., Li, W., Zhang, M., Hu, H., Qiao, M., Zhao, X., & Chen, D. (2016) · RSC Advances · doi:10.1039/c5ra22463b · Cited by 22 · see citing works
Formulation Strategies for Pulmonary Delivery of Poorly Soluble Drugs
Wauthoz, N., & Amighi, K. (2015) · Wiley eBooks · doi:10.1002/9781118799536.ch5 · Cited by 21 · see citing works
Nanomaterials for oral drug administration
Bertoni, S., Passerini, N., & Albertini, B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818038-9.00004-1 · Cited by 20 · see citing works
Lin, Y. H., & Chen, C. (2020) · Polymers · doi:10.3390/polym12102280 · Cited by 19 · see citing works
Prima, G. D., Licciardi, M., Bongiovì, F., Pitarresi, G. L., & Giammona, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091431 · Cited by 19 · see citing works
Kandžija, N., & Khutoryanskiy, V. V. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.05.022 · Cited by 17 · see citing works
Preparation, characterization and in vitro study of bellidifolin nano-micelles
Gao, F., Chen, Z., Zhou, L., Xiao, X., Wang, L., Liu, X., Wang, C., & Guo, Q.-H. (2022) · RSC Advances · doi:10.1039/d2ra02779h · Cited by 15 · see citing works
Gardey, E., Cseresnyés, Z., Sobotta, F. H., Eberhardt, J., Haziri, D., Grunert, P., Kuchenbrod, M. T., Gruschwitz, F. V., Hoeppener, S., Schümann, M., et al. (2023) · Small · doi:10.1002/smll.202306482 · Cited by 14 · see citing works
Sipos, B., Földes, F., Budai-Szűcs, M., Katona, G., & Csóka, I. (2024) · Gels · doi:10.3390/gels10080521 · Cited by 14 · see citing works
He, W., Wang, Y., Lv, Y., Xiao, Q., Ye, L., Cai, B., Qin, C., Han, X., Cai, T., & Yin, L. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02577c · Cited by 13 · see citing works
Polymeric micelles for oral drug delivery: progress and innovations in preclinical studies
Al-Lawati, H., & Binkhathlan, Z. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126373 · Cited by 11 · see citing works
Miao, Z., Gu, M., Yan, J., Lu, L., Xu, Y., Ning, L., & Xu, Y. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2052887 · Cited by 11 · see citing works
Mechanism of charge self-reversal nano-nutrient delivery system to overcome the mucosal barrier
Bian, Y., Yang, T., Qu, Z., Zhang, T., Yang, C., Chen, G., Chen, Y., & Li, S. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155594 · Cited by 10 · see citing works
Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
Guareschi, F., Favero, E. D., Ricci, C., Cantú, L., Brandolini, M., Sambri, V., Nicoli, S., Pescina, S., D’Angelo, D., Rossi, I., et al. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106673 · Cited by 10 · see citing works
Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability
Bierbrauer, K. L., Comini, L. R., Leonhard, V., Manzanelli, M. A. E., Castelli, G., Farfán, S., Alasino, R. V., & Beltramo, D. M. (2023) · Polymers · doi:10.3390/polym15071793 · Cited by 9 · see citing works
Verma, P., Gupta, G. D., Markandeywar, T. S., & Singh, D. (2023) · Assay and Drug Development Technologies · doi:10.1089/adt.2022.079 · Cited by 9 · see citing works
Polymeric Micelles for Targeted Drug Delivery Systems
Guliy, O. I., Fomin, A. S., Григорьевна, Ж. Е., Kozlov, S., Staroverov, S. A., & Dykman, L. A. (2022) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-12658-1_18 · Cited by 8 · see citing works
A Review on Nanomedicinal and Nanosensing Potential of Nanoparticles
Jasuja, N. D., Sharma, G., Ali, M. I., & Joshi, S. C. (2014) · International Journal of Biological Chemistry · doi:10.3923/ijbc.2014.58.84 · Cited by 8 · see citing works
Posaconazole-hemp seed oil loaded nanomicelles for invasive fungal disease
Rathee, A. S., Solanki, P., Emad, N. A., Zai, I., Ahmad, S., Alam, S., Alqahtani, A. S., Noman, O. M., Kohli, K., & Sultana, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-66074-1 · Cited by 7 · see citing works
Oral insulin delivery – challenges and strategies
Sonia, T. A., & Sharma, C. P. (2014) · Elsevier eBooks · doi:10.1533/9781908818683.113 · Cited by 7 · see citing works
Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying
Sipos, B., Katona, G., Szarvas, F. M., Budai-Szűcs, M., Ambrus, R., & Csóka, I. (2023) · Pharmaceuticals · doi:10.3390/ph16101447 · Cited by 6 · see citing works
Polymeric Micelles for Targeted Drug Delivery System
Guliy, O. I., Staroverov, S. A., Fomin, A. S., Григорьевна, Ж. Е., Kozlov, S., Lovtsova, L. G., & Dykman, L. A. (2022) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683822060059 · Cited by 7 · see citing works
Gerardos, A. M., Balafouti, A., & Pispas, S. (2023) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202300109 · Cited by 6 · see citing works
Liu, C., Cui, Z., Zhang, X., & Mao, S. (2020) · Springer eBooks · doi:10.1007/978-981-32-9840-8_13 · Cited by 6 · see citing works
Mundada, A. S., Kothari, L. P., Vinchurkar, K., Yadav, S., Malhan, A., Guleria, M., & Singh, S. K. (2025) · Current Drug Delivery · doi:10.2174/0115672018379860250722161458 · Cited by 4 · see citing works
Türkmen, Ö., & Baloğlu, E. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103836 · Cited by 4 · see citing works
Kailasam, V., Malani, M., & Nirmal, J. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126162 · Cited by 3 · see citing works
Ayodele, S., Kumar, P., Eyk, A. D. V., van der Bijl, P., & Choonara, Y. E. (2025) · Molecules · doi:10.3390/molecules30132845 · Cited by 3 · see citing works
Addressing the polycation dilemma in drug delivery: charge-converting liposomes
Truszkowska, M., Saleh, A., Ebert, M. L., Kali, G., & Bernkop‐Schnürch, A. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00945f · Cited by 3 · see citing works
Effects of block copolymer micelles on the pharmacokinetics of encapsulated drugs
Binkhathlan, Z., & Lavasanifar, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816200-2.00017-7 · Cited by 3 · see citing works
Rodríguez-Gutiérrez, J., Torres-Agullo, A., Lacorte, S., Jasso-Arreola, Y., Santolalla-Vargas, C. E., Ayllón-Vergara, J. C., & Mendoza, L. A. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128688 · Cited by 2 · see citing works
Chen, L. (2013) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 2 · see citing works
Stability of Polymeric Micelles and Their Regulatory Status
Thirugnanasambandham, I., Aasaithambi, K., Nizam, I., & Kuppusamy, G. (2023) · Springer eBooks · doi:10.1007/978-981-99-0361-0_15 · Cited by 3 · see citing works
Design and Development of Ocular Formulations for Preclinical and Clinical Trials
Schmitt, M. (2019) · Methods and principles in medicinal chemistry · doi:10.1002/9783527812172.ch10 · Cited by 2 · see citing works
Clinical translation of polymeric micelles into market
Raslan, M., Eslam, M. S., Sara, A. R., & Sabri, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89868-3.00008-2 · Cited by 1 · see citing works
Diab, Z. F., Fares, A. R., El-Gazayerly, O. N., & AbouGhaly, M. H. H. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.107999 · Cited by 1 · see citing works
Tian, J.-Y., Bai, R., Chen, Z., Qin, P., Liu, X., Shen, H., Zhou, L., & Guo, Q. (2023) · Current Pharmaceutical Analysis · doi:10.2174/0115734129253094231018115646 · Cited by 1 · see citing works
Polymeric micelles for drug delivery: properties, designs and applications
Raina, N., Singh, M., Rani, R., Garg, A., Sharma, A., Kumar, P., & Gupta, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-819979-4.00006-4 · Cited by 1 · see citing works
Ni, X., Li, Q., Sun, Y., Deng, Z., & Li, J. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118521 · Cited by 1 · see citing works
Zhuravskii, S. G., Эдуардович, Ш. А., Yukina, G. Y., Самусенко, И. А., & Kryzhanovskaya, E. A. (2019) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-019-04535-8 · Cited by 1 · see citing works
Mucoadhesive polymers in ophthalmic therapy
Horvát, G. (2016) · doi:10.14232/phd.2828
Polymeric micellar nanocarriers: topical treatment of inflammatory diseases
Kahraman, E., Durgun, M. E., Güngör, S., & Özsoy, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89868-3.00011-2
Szarvas, F. (2023) · Az SZTE Gyógyszerésztudományi Kar ÚNKP díjazottjainak tudományos előadóülése · doi:10.14232/gytk.unkp.2023.18
Cell-based in vitro models for transcorneal permeability studies
Dukovski, B. J., Juretić, M., Reichl, S., Pepić, I., & Lovrić, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15510-9.00016-5
Polymeric micelles in colon targeting
Patel, V., Hariharan, K., Halder, A., Khopade, A. J., & Patel, J. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-24806-1.00007-8
HASHIM, H. H., & Jaber, S. A. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i5.55349
Oral insulin delivery—Challenges and strategies
Sonia, T. A., & Sharma, C. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30272-5.00012-3
- Authors
- Pepić, I., Lovrić, J., & Filipović-Grčić, J.
- Affiliations
- University of Zagreb (HR)
- Corresponding author
- Pepić, Ivan
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 50
- Issue
- 1
- Pages
- 42-55
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W2031754029
- Cited by
- 102
- References
- 106
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 13 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hrvatska Zaklada za Znanost
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- polymeric micelles, epithelial barrier function, mucus, surface decoration, intracellular fate
- MeSH terms
- Absorption, Animals, Biocompatible Materials, Cell Membrane, Drug Carriers, Endocytosis, Epithelium, Humans, Micelles, Particle Size, Polymers, Surface Properties, Drug Delivery Systems, Administration, Mucosal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
