The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effects of VEGF temporal and spatial presentation on angiogenesis
Open accessAbstract
Therapeutic angiogenesis relies on the delivery of angiogenic factors capable of reversing tissue ischemia. Polymeric materials that can provide spatial and temporal over vascular endothelial growth factor (VEGF) presentation provide clear benefit, but the influence of VEGF dose, temporal, and spatial presentation on the resultant angiogenic process are largely unknown. The influence of the temporal profile of VEGF concentration, dose, and the impact of VEGF spatial distribution on angiogenesis in in vitro models of angiogenesis and ischemic murine limbs was analyzed in this study. Importantly, a profile consisting of a high VEGF concentration initially, followed by a decreasing concentration over time was found to yield optimal angiogenic sprouting. A total VEGF dose 0.1 μg/g, when delivered with kinetics found to be optimal in vitro, provided a favorable therapeutic dose in murine hindlimb ischemia model, and distributing this VEGF dose in two spatial locations induces a higher level of vascularization and perfusion than a single location. These findings suggest that material systems capable of controlling and regulating the temporal and spatial presentation of VEGF maybe useful to achieve a robust and potent therapeutic angiogenic effect in vivo.
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Cites
Projections of Global Mortality and Burden of Disease from 2002 to 2030
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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
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Angiogenesis as a therapeutic target
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“There is a significant need for new approaches to promote blood vessel formation in ischemic diseases, as these diseases remain the dominant cause of mortality worldwide [1,2].”
BackgroundInhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
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Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair
Hu, K., & Olsen, B. R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82585 · Cited by 668
Microfluidic techniques for development of 3D vascularized tissue
Hasan, A., Paul, A., Vrana, N. E., Zhao, X., Memic, A., Hwang, Y.-S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.091 · Cited by 282
Substrates for cardiovascular tissue engineering
Bouten, C. V. C., Dankers, P. Y. W., Driessen-Mol, A., Pedron, S., Brizard, A. M. A., & Baaijens, F. P. T. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.007 · Cited by 261
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Metadata
- Authors
- Silva, E. A., & Mooney, D. J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 31
- Issue
- 6
- Pages
- 1235-1241
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2079273552
- Cited by
- 246
- References
- 5
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
