The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs
Open accessAbstract
Solubilization of highly hydrophobic drugs with carriers that are non-toxic, non-immunogenic and well-defined remains a major obstacle in pharmaceutical sciences. Well defined amphiphilic di- and triblock copolymers based on poly(2-oxazolines) were prepared and used for the solubilization of Paclitaxel (PTX) and other water-insoluble drugs. Probing the polymer micelles in water with the fluorescence probe pyrene, an unusual high polar microenvironment of the probe was observed. This coincides with an extraordinary large loading capacity for PTX of 45 wt.% active drug in the formulation as well as high water solubility of the resulting formulation. Physicochemical properties of the formulations, ease of preparation and stability upon lyophilization, low toxicity and immunogenicity suggest that poly(2-oxazoline)s are promising candidates for the delivery of highly challenging drugs. Furthermore, we demonstrate that PTX is fully active and provides superior tumor inhibition as compared to the commercial micellar formulation.
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Cites
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Self-citationMicellar Nanocontainers Distribute to Defined Cytoplasmic Organelles
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Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699
Self-citationPoly (2-oxazoline) s as polymer therapeutics
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Self-citationPoly(2-oxazoline)s based biomaterials: a comprehensive and critical update
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Self-citationNanocarriers for delivery of platinum anticancer drugs
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Self-citationOn the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s
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Metadata
- Authors
- Luxenhofer, R., Schulz, A., Roques, C., Li, S., Bronich, T. K., Batrakova, E. V., Jordan, R., & Kabanov, A. V.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 31
- Issue
- 18
- Pages
- 4972-4979
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2080774121
- Cited by
- 286
- References
- 44
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Luxenhofer, R., Schulz, A., Roques, C., Li, S., Bronich, T. K., Batrakova, E. V., Jordan, R., & Kabanov, A. V. (2010). Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs. Biomaterials. https://doi.org/10.1016/j.biomaterials.2010.02.057
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