Cited by 261Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications

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Biologic scaffold composed of skeletal muscle extracellular matrix

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Wolf, Matthew T., Daly, Kerry A., Reing, Janet E., Badylak, Stephen F.·2012·Biomaterials

DOI 10.1016/j.biomaterials.2011.12.055PMC PMC5942557

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Abstract

Biologic scaffolds prepared from the extracellular matrix (ECM) of decellularized mammalian tissues have been shown to facilitate constructive remodeling in injured tissues such as skeletal muscle, the esophagus, and lower urinary tract, among others. The ECM of every tissue has a unique composition and structure that likely has direct effects on the host response and it is plausible that ECM harvested from a given tissue would provide distinct advantages over ECM harvested from nonhomologous tissues. For example, a tissue specific muscle ECM scaffold may be more suitable for constructive remodeling of skeletal muscle than non-homologous ECM tissue sources. The present study describes an enzymatic and chemical decellularization process for isolating skeletal muscle ECM scaffolds using established decellularization criteria and characterized the structure and chemical composition of the resulting ECM. The results were compared to those from a non-muscle ECM derived from small intestine (SIS). Muscle ECM was shown to contain growth factors, glycosaminoglycans, and basement membrane structural proteins which differed from those present in SIS. Myogenic cells survived and proliferated on muscle ECM scaffolds in vitro, and when implanted in a rat abdominal wall injury model in vivo was shown to induce a constructive remodeling response associated with scaffold degradation and myogenesis in the implant area; however, the remodeling outcome did not differ from that induced by SIS by 35 days post surgery. These results suggest that superior tissue remodeling outcomes are not universally dependent upon homologous tissue derived ECM scaffold materials.

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Authors: Wolf, M. T., Daly, K. A., Reing, J. E., & Badylak, S. F.
Affiliations: University of Pittsburgh (US)
Corresponding author: Badylak, Stephen F.
ORCID: Wolf, Matthew T.
Reing, Janet E.
Badylak, Stephen F.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2012-04
Volume: 33
Issue: 10
Pages: 2916-2925
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2011.12.055
PMC: PMC5942557
OpenAlex: W2050261148
Cited by: 259
References: 48
Citations by year: 2026: 4 · 2025: 9 · 2024: 16 · 2023: 5 · 2022: 17 · 2021: 20 · 2020: 20 · 2019: 24 · 2018: 19 · 2017: 23 · 2016: 26 · 2015: 25 · 2014: 21 · 2013: 25 · 2012: 4
FWCI: 24.49
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Pittsburgh
National Institutes of Health
National Heart, Lung, and Blood Institute (T32-HL76124-6, T32HL076124)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: decellularization, biological scaffolds, small intestinal submucosa, tissue remodeling, myogenesis, abdominal wall injury, scaffold degradation, growth factors, glycosaminoglycans, basement membrane proteins
MeSH terms: Animals, DNA, Dogs, Extracellular Matrix, Glycosaminoglycans, Humans, Materials Testing, Oxazines, Staining and Labeling, Xanthenes, Reproducibility of Results, Muscle, Skeletal, Prosthesis Implantation, Sus scrofa, Abdominal Wall, Intercellular Signaling Peptides and Proteins, NIH 3T3 Cells, Mice, Rats, Tissue Scaffolds

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