Monodisperse magnetite nanoparticle tracers for in vivo magnetic particle imaging
Open accessAbstract
Magnetic Particle Imaging (MPI) is a new biomedical imaging modality that produces real-time, high-resolution tomographic images of superparamagnetic iron oxide (SPIO) nanoparticle tracer distributions. In this study, we synthesized monodisperse tracers for enhanced MPI performance and investigated both, their blood clearance time using a 25 kHz magnetic particle spectrometer (MPS), and biodistribution using a combination of quantitative T2-weighted MRI and tissue histology. In vitro and in vivo MPI performance of our magnetic nanoparticle tracers (MNTs), subject to biological constraints, were compared to commercially available SPIOs (Resovist). Monodisperse MNTs showed a 2-fold greater signal per unit mass, and 20% better spatial resolution. In vitro evaluation of tracers showed that MPI performance of our MNTs is preserved in blood, serum-rich cell-culture medium and gel; thus independent of changes in hydrodynamic volume and fluid viscosity - a critical prerequisite for in vivo MPI. In a rodent model, our MNTs circulated for 15 min - 3× longer than Resovist - and supported our in vitro evaluation that MPI signal is preserved in the physiological environment. Furthermore, MRI and histology analysis showed that MNTs distribute in the reticuloendothelial system (RES) in a manner similar to clinically approved SPIO agents. MNTs demonstrating long-circulation times and optimized MPI performance show potential as angiography tracers and blood-pool agents for the emerging MPI imaging modality.
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Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.
“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [9]
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- Authors
- Khandhar, A. P., Ferguson, R. M., Arami, H., & Krishnan, K. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Krishnan, Kannan M.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 34
- Issue
- 15
- Pages
- 3837-3845
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC3602155
- OpenAlex
- W2107474730
- Cited by
- 152
- References
- 36
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 6 · 2018: 21 · 2017: 15 · 2016: 8 · 2015: 20 · 2014: 11 · 2013: 8
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (1R01EB013689-01/NIBIB, 1R41EB013520-01)
- NSF (IIP-1215556)
- UW/CGF commercialization
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Geomagnetism and Paleomagnetism Studies
- Keywords
- magnetic particle imaging, superparamagnetic iron oxide nanoparticles, nanoparticle tracers, tissue distribution, blood clearance, reticuloendothelial system, blood pool agents, T2-weighted MRI, in vivo imaging
- MeSH terms
- Animals, Dextrans, Diagnostic Imaging, Female, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetics, Organ Specificity, Spectrum Analysis, Tissue Distribution, Mice, Magnetite Nanoparticles
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