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Nanostructured platinum grass enables superior impedance reduction for neural microelectrodes
Open accessAbstract
Micro-sized electrodes are essential for highly sensitive communication at the neural interface with superior spatial resolution. However, such small electrodes inevitably suffer from high electrical impedance and thus high levels of thermal noise deteriorating the signal to noise ratio. In order to overcome this problem, a nanostructured Pt-coating was introduced as add-on functionalization for impedance reduction of small electrodes. In comparison to platinum black deposition, all used chemicals in the deposition process are free from cytotoxic components. The grass-like nanostructure was found to reduce the impedance by almost two orders of magnitude compared to untreated samples which was lower than what could be achieved with conventional electrode coatings like IrOx or PEDOT. The realization of the Pt-grass coating is performed via a simple electrochemical process which can be applied to virtually any possible electrode type and accordingly shows potential as a universal impedance reduction strategy. Elution tests revealed non-toxicity of the Pt-grass and the coating was found to exhibit strong adhesion to the metallized substrate.
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“The deposition processes for platinum black have reportedly caused cytotoxic reactions due to lead traces found in the electroplating electrolyte (Schuettler et al. 2005b). This was not observed for nanostructured platinum grass (Boehler et al. 2015).”
From Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations (2018) · cites this paper as Boehler et al. 2015
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Metadata
- Authors
- Boehler, C., Stieglitz, T., & Asplund, M.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Boehler, C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 67
- Pages
- 346-353
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1190686642
- Cited by
- 179
- References
- 35
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 17 · 2020: 19 · 2019: 22 · 2018: 10 · 2017: 11 · 2016: 4
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomaterials (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- German Research Foundation (EXC 1086)
- Freiburg Institute for Advanced Studies (FRIAS), funded by the German Excellence Initiative
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- neural microelectrodes, platinum coating, platinum black, electrodeposition, neural interfaces, thermal noise, signal-to-noise ratio, electrode functionalization, cytotoxicity, coating adhesion
- MeSH terms
- Cell Survival, Humans, Imides, Microelectrodes, Neurons, Platinum, Electric Impedance, Cell Line, Tumor, Nanostructures, Electrochemical Techniques, Optical Imaging
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