Cited by 1,004Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers

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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, Manju, Wilson, William R., Yang, Mimi, Palmer, Brian D., Wu, Zimei·2016·Biomaterials

DOI 10.1016/j.biomaterials.2016.01.061

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Abstract

As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new strategy for addressing the limitations of the conventional chemotherapy. In the last decade, the volume of research published in this area has increased tremendously, especially with functional nano drug delivery systems (nanocarriers). Coupling a specific stimuli-triggered drug release mechanism with these delivery systems is one of the most prevalent approaches for improving therapeutic outcomes. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumours. In this review, we discuss recent advances in the development of pH-sensitive nanocarriers for tumour-targeted drug delivery. The review focuses on the chemical design of pH-sensitive biomaterials, which are used to fabricate nanocarriers for extracellular and/or intracellular tumour site-specific drug release. The pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release. A greater understanding of these mechanisms will help to design more efficient drug delivery systems to address the challenges encountered in conventional chemotherapy.

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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,781
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Untitled work
(1989) · PubMed · Cited by 3,343
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
A review of stimuli-responsive nanocarriers for drug and gene delivery
Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,198
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
WICKI, A. N., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,962
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Lipid polymorphism and the functional roles of lipids in biological membranes
Cullis, P. R., & KRUIJFF, B. D. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(79)90012-1 · Cited by 1,865

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Show all 213 references

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Research works printed but not linked: 4

Immordino, 2006, Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential, Int. J. Nanomedicine, 1, 297
Liu, 2014, pH-Sensitive nano-systems for drug delivery in cancer therapy, Biotechnol. Adv., 32, 693, 10.1016/j.biotechadv.2013.11.009 · DOI · Paper page
Sun, 2014, Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds, Biomaterials, 35, 836, 10.1016/j.biomaterials.2013.10.011 · DOI
Carmali, 2014, Chapter 13-polyacetals, 219

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Background
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Background
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“Currently, pHsensitive strategies have been applied to drug or gene delivery according to low extracellular pHex or endosomal pHen [13].”
BackgroundMethod
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Self-assembly of folic acid dextran conjugates for cancer chemotherapy
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Jiang, Z., Yuan, B., Qiu, N., Wang, Y., Sun, L. X., Wei, Z., Li, Y., Zheng, J., Jin, Y., Li, Y., et al. (2019) · Nano-Micro Letters · doi:10.1007/s40820-019-0292-y · Cited by 59
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Background
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“This system remains stable at physiological pH but releases the encapsulated drug selectively within acidic tumour tissues [83,186,187].”
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“4), which results from a difference in the glucose metabolic pathway [19,20].”
Background
Development of “smart” drug delivery systems for chemo/PDT synergistic treatment
Yu, M., Cao, R., Ma, Z., & Zhu, M. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02248f · Cited by 55
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Duan, Z., Cai, H., Zhang, H., Chen, K., Li, N., Xu, Z., Gong, Q., & Luo, K. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b12232 · Cited by 55
β‐Cyclodextrin‐Decorated Carbon Dots Serve as Nanocarriers for Targeted Drug Delivery and Controlled Release
Yang, T., Huang, J., Wang, Y., Zheng, A., Shu, Y., & Wang, J. (2018) · ChemNanoMat · doi:10.1002/cnma.201800528 · Cited by 52
Computer Simulations on a pH-Responsive Anticancer Drug Delivery System Using Zwitterion-Grafted Polyamidoamine Dendrimer Unimolecular Micelles
Zeng, S., Quan, X., Zhu, H., Sun, D., Miao, Z., Zhang, L., & Zhou, J. W. (2021) · Langmuir · doi:10.1021/acs.langmuir.0c03217 · Cited by 51
Polymer-based and stimulus-responsive carriers for controlled release of agrochemicals
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Stimuli-sensitive polymer prodrug nanocarriers by reversible-deactivation radical polymerization
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Research Progress of Metal–Organic Frameworks as Drug Delivery Systems
Liu, C., Tian, C., Guo, J., Zhang, X., Wu, L., Zhu, L. Z., & Du, B. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c09536 · Cited by 55
Host-guest fabrication of dual-responsive hyaluronic acid/mesoporous silica nanoparticle based drug delivery system for targeted cancer therapy
Lu, J., Luo, B., Chen, Z., Yuan, Y., Kuang, Y., Wan, L., Li, Y., Chen, X., Jiang, B., Liu, J., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.265 · Cited by 51
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Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer
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“Our recent studies have shown that extracellular ATP (eATP) in TME is found in concentrations 103 to 104 times higher than eATP found in normal tissues[1-5].”
BackgroundInfluential
Stimuli-responsive chitosan-based nanocarriers for drug delivery in wound dressing applications: A review
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Dual-Sensitive Hydrogel Nanoparticles Based on Conjugated Thermoresponsive Copolymers and Protein Filaments for Triggerable Drug Delivery
Ghaffari, R., Eslahi, N., Tamjid, E., & Simchi, A. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b01154 · Cited by 50
DNA-Functionalized Hollow Mesoporous Silica Nanoparticles with Dual Cargo Loading for Near-Infrared-Responsive Synergistic Chemo-Photothermal Treatment of Cancer Cells
Hai, L., Jia, X., He, D., Zhang, A., Wang, T., Cheng, H., He, X., & Wang, K. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00657 · Cited by 50
Nanocarriers as Potential Targeted Drug Delivery for Cancer Therapy
Singhvi, G., Rapalli, V. K., Nagpal, S., Dubey, S. K., & Saha, R. N. (2020) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-030-29207-2_2 · Cited by 50
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van Oirschot, B. A. J. A., Zhang, Y., Alghamdi, H. S., Cordeiro, J. M., NAGAY, B. E., Barão, V. A. R., de Avila, E. D., & van den Beucken, J. J. J. P. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2021.0230 · Cited by 54
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Zhang, H., Chen, W., Wang, J., Du, W., Wang, B., Song, L., Hu, Y. Z., & Ma, X. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121954 · Cited by 50
Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction
Du, X., Sun, Y. L., Zhang, M., He, J., & Ni, P. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b02281 · Cited by 49
State of the Art of Stimuli-Responsive Liposomes for Cancer Therapy.
Heidarli, E., Dadashzadeh, S., & Haeri, A. (2017) · PubMed Central · Cited by 49
Smart dendrimers: Synergizing the targeting of anticancer bioactives
Saluja, V., Mankoo, A., Saraogi, G. K., Tambuwala, M. M., & Mishra, V. K. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.04.014 · Cited by 49
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Anirudhan, T. S., & Christa, J. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101476 · Cited by 49
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Lorkowski, M. E., Atukorale, P. U., Ghaghada, K. B., & Karathanasis, E. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001044 · Cited by 50
Nanovesicle-Mediated Delivery Systems for CRISPR/Cas Genome Editing
Kim, D., Le, Q., Wu, Y., Park, J.-W., & Oh, Y. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121233 · Cited by 51
“These studies have focused on the low (acidic) pH of tumor tissue and endosomes as triggers for activation of delivery systems [153,154].”
Background
Optimal loading of hydrogel-based drug-delivery systems
Penn, M. J., & Hennessy, M. G. (2022) · Applied Mathematical Modelling · doi:10.1016/j.apm.2022.08.008 · Cited by 48
“For example, environmentally responsive hydrogels have been used to target tumours [6] and breast cancer cells [7] by exploiting local increases in pH and temperature relative to healthy tissue.”
Background
The design of multi-responsive nanohydrogel networks of chitosan for controlled drug delivery
Omrani, M., Naimi‐Jamal, M. R., & Far, B. F. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120143 · Cited by 48
Chitooligosaccharides Modified Reduction-Sensitive Liposomes: Enhanced Cytoplasmic Drug Delivery and Osteosarcomas-Tumor Inhibition in Animal Models
Yin, X., Chi, Y., Guo, C., Feng, S., Liu, J., Sun, K., & Wu, Z. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2225-0 · Cited by 48
Self-citation
Molecular bionics – engineering biomaterials at the molecular level using biological principles
Rodríguez‐Arco, L., Poma, A., Ruiz‐Pérez, L., Scarpa, E., Ngamkham, K., & Battaglia, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.044 · Cited by 49
“pH-responsive delivery systems pH sensitive materials can be designed either using building blocks that change solubility according to the protonation state or through the insertion of acid-cleavable bonds [360].”
Background
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Qian, Q., Zhu, L., Zhu, X., Sun, M., & Yan, D. (2019) · Matter · doi:10.1016/j.matt.2019.09.016 · Cited by 48
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Huang, X., Hu, J., Li, Y., Xin, F., Qiao, R., & Davis, T. P. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b01158 · Cited by 49
Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery
Shi, Z., Zeng, Y., Chen, X., Zhou, F., Zheng, L., Wang, G., Gao, J., Ma, Y., Zheng, L., Fu, B., et al. (2019) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2019.166222 · Cited by 48
Pure redox-sensitive paclitaxel–maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency
Lou, X., Zhang, D., Ling, H., He, Z., Sun, J., Sun, M., & Liu, D. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.001 · Cited by 48
Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases
Dai, X., Li, W., Xie, D., Liu, B., Gong, L., & Han, H. (2025) · Small · doi:10.1002/smll.202410030 · Cited by 47
Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging
Kim, S., Yun, G., Khan, S., Kim, J., Murray, J. K., Jr., Lee, Y. M., Kim, W. J., Lee, G., Kim, S., Shetty, D., et al. (2017) · Materials Horizons · doi:10.1039/c7mh00038c · Cited by 47
pH and magnetic field sensitive folic acid conjugated protein–polyelectrolyte complex for the controlled and targeted delivery of 5-fluorouracil
Anirudhan, T. S., Christa, J., & Binusreejayan, B. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.08.024 · Cited by 47
100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery
Sun, H., & Zhong, Z. (2020) · ACS Macro Letters · doi:10.1021/acsmacrolett.0c00488 · Cited by 47
Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles
Butt, A. M., Abdullah, N., Rani, N. N. I. M., Ahmad, N., & Amin, M. C. I. M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03296-w · Cited by 51
“Mechanisms of pH sensitive lipids, cationic lipids, or lipids with multiple charges for endosome escape have been reviewed in detail elsewhere (67).”
Background
Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases
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Pegylated and folic acid functionalized carbon nanotubes as pH controlled carriers of doxorubicin. Molecular dynamics analysis of the stability and drug release mechanism
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One-pot synthesis of pH-responsive hyperbranched polymer–peptide conjugates with enhanced stability and loading efficiency for combined cancer therapy
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Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency
Ke, W., Lu, N., Japir, A. A.-W. M. M., Zhou, Q., Xi, L., Wang, Y., Dutta, D., Zhou, M., Pan, Y., & Ge, Z. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.012 · Cited by 47
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Rosenfeld, L., Sananes, A., Zur, Y., Cohen, S., Dhara, K., Gelkop, S., Ben‐Zeev, E., Shahar, A., Lobel, L. I., Akabayov, B., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00418 · Cited by 50
Multi‐Mode Reconfigurable DNA‐Based Chemical Reaction Circuits for Soft Matter Computing and Control
Tang, Q., Lai, W., Wang, P., Xiong, X., Xiao, M., Li, L., Fan, C., & Pei, H. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202102169 · Cited by 46
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Wu, J., Xue, X., & Qu, H. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100092 · Cited by 45
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Battistella, C., & Klok, H. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700022 · Cited by 45
Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper
Cho, I.-H., Shim, M. K., Jung, B., Jang, E. H., Park, M.-J., Kang, H. C., & Kim, J.-H. (2017) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2017.06.042 · Cited by 45
A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6‑mercaptopurine
Ghorbani, M., & Hamishehkar, H. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.07.019 · Cited by 45
Charge-conversion and ultrasound-responsive O-carboxymethyl Chitosan Nanodroplets for Controlled Drug Delivery
Meng, D., Guo, L., Shi, D., Sun, X. Y., Shang, M., Zhou, X., & Li, J. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0217 · Cited by 45
Direct Visualization of Vesicle Disassembly and Reassembly Using Photocleavable Dendrimers Elucidates Cargo Release Mechanisms
Li, S., Xia, B., Javed, B., Hasley, W. D., Melendez-Davila, A., Liu, M., Kerzner, M., Agarwal, S., Xiao, Q., Torre, P., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c02912 · Cited by 45
Preparation of sodium alginate-poly (vinyl alcohol) blend beads for base-triggered release of dinotefuran in Spodoptera litera midgut
Wang, S., Ma, Q., Wang, R., Zhu, Q., Yang, L., & Zhang, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110935 · Cited by 45
Self-Assembled pH-Sensitive Nanoparticles Based on Ganoderma lucidum Polysaccharide–Methotrexate Conjugates for the Co-delivery of Anti-tumor Drugs
Zheng, D., Zhao, J., Li, Y., Zhu, L., Jin, M., Wang, L., Liu, J., Lei, J., & Li, Z. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00663 · Cited by 45
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Bonacchi, S., Cantelli, A., Battistelli, G., Guidetti, G., Calvaresi, M., Manzi, J., Gabrielli, L., Ramadori, F., Gambarin, A., Mancin, F., et al. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604290 · Cited by 44
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Xue, B., Wang, W., Qin, J., Nijampatnam, B., Srinivasan, M., Kozlovskaya, V., Zhang, R., Velu, S. E., & Kharlampieva, E. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.06.004 · Cited by 45
Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH
Qiao, Z., Zhao, W., Gao, Y., Cong, Y., Zhao, L., Hu, Z., & Wang, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09033 · Cited by 44
Fabrication of Cellulose-Nanocrystal-Based Folate Targeted Nanomedicine via Layer-by-Layer Assembly with Lysosomal pH-Controlled Drug Release into the Nucleus
Li, N., Zhang, H., Xiao, Y., Huang, Y., Xu, M., You, D., Lu, W. P., & Yu, J. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.8b01556 · Cited by 44
Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
Karami, A., Ahmed, A., Sabouni, R., Husseini, G. A., Sharabati, M. A., AlSawaftah, N., & Paul, V. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112599 · Cited by 43

Authors: Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z.
Affiliations: University of Auckland (NZ)
Corresponding author: Wu, Zimei
ORCID: Wilson, William R.
Yang, Mimi
Wu, Zimei
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2016-04
Volume: 85
Pages: 152-167
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2016.01.061
OpenAlex: W2288119981
Cited by: 1,004
References: 213
Citations by year: 2026: 65 · 2025: 96 · 2024: 78 · 2023: 85 · 2022: 99 · 2021: 117 · 2020: 129 · 2019: 113 · 2018: 108 · 2017: 77 · 2016: 37
FWCI: 5.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion)
Funders: Royal Society of New Zealand (UOA1201)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: pH-responsive nanocarriers, tumour-targeted drug delivery, stimuli-responsive drug release, intracellular drug release, protonation, charge reversal, bond cleavage, tumor selectivity, multidrug resistance, chemotherapy
MeSH terms: Animals, Biocompatible Materials, Clinical Trials as Topic, Disease Models, Animal, Humans, Hydrogen-Ion Concentration, Neoplasms, Drug Delivery Systems, Nanotechnology, Nanostructures, Drug Liberation

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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

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